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Database: UniProt
Entry: H2QX87_PANTR
LinkDB: H2QX87_PANTR
Original site: H2QX87_PANTR 
ID   H2QX87_PANTR            Unreviewed;       927 AA.
AC   H2QX87;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   07-JUN-2017, entry version 37.
DE   RecName: Full=Non-lysosomal glucosylceramidase {ECO:0000256|PIRNR:PIRNR028944};
DE            Short=NLGase {ECO:0000256|PIRNR:PIRNR028944};
DE            EC=3.2.1.45 {ECO:0000256|PIRNR:PIRNR028944};
GN   Name=GBA2 {ECO:0000313|Ensembl:ENSPTRP00000035782};
GN   Synonyms=TLN1 {ECO:0000313|EMBL:JAA11134.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000035782, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000035782, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000035782}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|EMBL:JAA11134.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA11134.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from
RT   NextGen mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non-lysosomal glucosylceramidase that catalyzes the
CC       conversion of glucosylceramide to free glucose and ceramide.
CC       {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- CATALYTIC ACTIVITY: D-glucosyl-N-acylsphingosine + H(2)O = D-
CC       glucose + N-acylsphingosine. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|PIRNR:PIRNR028944}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028944}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR028944}. Golgi apparatus membrane
CC       {ECO:0000256|PIRNR:PIRNR028944}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR028944}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR028944}. Note=Not localized to lipid
CC       rafts. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SIMILARITY: Belongs to the non-lysosomal glucosylceramidase
CC       family. {ECO:0000256|PIRNR:PIRNR028944}.
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DR   EMBL; AACZ03067156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01000204; JAA11134.1; -; mRNA.
DR   RefSeq; XP_520565.1; XM_520565.6.
DR   STRING; 9598.ENSPTRP00000035782; -.
DR   Ensembl; ENSPTRT00000038705; ENSPTRP00000035782; ENSPTRG00000020919.
DR   GeneID; 104001058; -.
DR   CTD; 57704; -.
DR   eggNOG; KOG2119; Eukaryota.
DR   eggNOG; COG4354; LUCA.
DR   GeneTree; ENSGT00390000010998; -.
DR   OMA; HDYQDSS; -.
DR   OrthoDB; EOG091G01JK; -.
DR   TreeFam; TF313888; -.
DR   Proteomes; UP000002277; Chromosome 9.
DR   Bgee; ENSPTRG00000020919; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:Ensembl.
DR   GO; GO:0008422; F:beta-glucosidase activity; IEA:Ensembl.
DR   GO; GO:0004348; F:glucosylceramidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008206; P:bile acid metabolic process; IEA:Ensembl.
DR   GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
DR   GO; GO:0006680; P:glucosylceramide catabolic process; IEA:InterPro.
DR   GO; GO:0016139; P:glycoside catabolic process; IEA:Ensembl.
DR   InterPro; IPR008928; 6-hairpin_glycosidase-like.
DR   InterPro; IPR014551; B_Glucosidase_GBA2-typ.
DR   InterPro; IPR006775; GH116_catalytic.
DR   InterPro; IPR024462; GH116_N.
DR   Pfam; PF04685; DUF608; 1.
DR   Pfam; PF12215; Glyco_hydr_116N; 1.
DR   PIRSF; PIRSF028944; Beta_gluc_GBA2; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR028944};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR028944};
KW   Golgi apparatus {ECO:0000256|PIRNR:PIRNR028944};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR028944};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR028944};
KW   Membrane {ECO:0000256|PIRNR:PIRNR028944};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT   DOMAIN      151    455       Glyco_hydr_116N. {ECO:0000259|Pfam:
FT                                PF12215}.
FT   DOMAIN      521    886       DUF608. {ECO:0000259|Pfam:PF04685}.
SQ   SEQUENCE   927 AA;  104711 MW;  F40DDDE673BCE829 CRC64;
     MGTQDPGNMG TGVPASEQIS CAKEDPQVYC PEETGGTKDV QVTDCKSPED SRPQKETDCC
     NPEDSGQLMV SYEGKAMGYQ VPPFGWRICL AHEFTEKRKP FQANNVSLSN MIKHIGMGLR
     YLQWWYRKTQ VEKKTPFIDM INSVPLRQIY GCPLGGIGGG TITRGWRGQF CRWQLNPGMY
     QHRTVIADQF TVCLRREGQT VYQQVLSLER PSVLRSWNWG LCGYFAFYHA LYPRAWTVYQ
     LPGQNVTLTC RQITPILPHD YQDSSLPVGV FVWDVENEGD EALDVSIMFS MRNGLGGGDD
     APGGLWNEPF CLERSGETVR GLLLHHPTLP NPYTMAVAAR VTAATTVTHI TAFDPDSTGQ
     QVWQDLLQDG QLDSPTGQST PTHKGVGIAG AVCVSSKLRP RGQCRLEFSL AWDMPRIMFG
     AKGQVHYRRY TRFFGQDGDA APALSHYALC RYTEWEERIS AWQSPVLDDR SLPAWYKSAL
     FNELYFLADG GTVWLEVLED SLPEELGRNM CHLRPTLRDY GRFGYLEGQE YRMYNTYDVH
     FYASFALIML WPKLELSLQY DMALATLRED LTRRRYLMSG VMAPVKRRNV IPHDIGDPDD
     EPWLRVNAYL IHDTADWKDL NLKFVLQVYR DYYLTGDQNF LKDMWPVCLA VMESEMKFDK
     DHDGLIENGG YADQTYDGWV TTGPSAYCGG LWLAAVAVMV QMAALCGAQD IQDKFSSILS
     RGQEAYERLL WNGRYYNYDS SSRPQSRSVM SDQCAGQWFL KACGLGEGDT EVFPTQHVVR
     ALQTIFELNV QAFAGGAMGA VNGMQPHGVP DKSSVQSDEV WVGVVYGLAA TMIQEGLTWE
     GFQTAEGCYR TVWERLGLAF QTPEAYCQQR VFRSLAYMRP LSIWAMQLAL QQQQHKKASW
     PKVEQGTGLR TGPMFGPKEA MANLSPE
//
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