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Database: UniProt
Entry: H2QY88_PANTR
LinkDB: H2QY88_PANTR
Original site: H2QY88_PANTR 
ID   H2QY88_PANTR            Unreviewed;      2312 AA.
AC   H2QY88;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 43.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSPTRP00000037005};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000037005, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000037005, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000037005}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; AACZ04062170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04062171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04062172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04062173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04062174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04062175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04062176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04062177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04062178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04062179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000037005; -.
DR   PaxDb; H2QY88; -.
DR   Ensembl; ENSPTRT00000040047; ENSPTRP00000037005; ENSPTRG00000021608.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H2QY88; -.
DR   OMA; THAWASI; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000002277; Chromosome 9.
DR   Bgee; ENSPTRG00000021608; -.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     96    113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    134    155       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    167    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    299    320       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    332    354       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    484    504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    510    527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    609    631       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    687    709       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1146   1164       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1184   1204       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1216   1234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1277   1299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1389   1414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1470   1488       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1500   1523       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1535   1559       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1580   1609       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1675   1694       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1813   1847       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      362    382       {ECO:0000256|SAM:Coils}.
FT   COILED      712    738       {ECO:0000256|SAM:Coils}.
FT   COILED      989   1014       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2312 AA;  259505 MW;  626DD14154B6A9C8 CRC64;
     MVRFGDELGG RYGGPGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA QRARTMALYN
     PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPYPYMI LATIIANCIV LALEQHLPDG
     DKTPMSERLD DTEPYFIGIF CFEAGIKIIA LGFVFHKGSY LRNGWNVMDF VVVLTGILAT
     AGTDFDLRTL RAVRVLRPLK LVSGIPSLQV VLKSIMKAMV PLLQIGLLLF FAILMFAIIG
     LEFYMGKFHK ACFPNSTDAE PVGDFPCGKE APARLCEGDT ECREYWPGPN FGITNFDNIL
     FAILTVFQCI TMEGWTDILY NTNDAAGNTW NWLYFIPLII IGSFFMLNLV LGVLSGEFAK
     ERERVENRRA FLKLRRQQQI ERELNGYLEW IFKAEEVMLA EEDRNAEEKS PLDAVLKRAA
     TKKSRNDLIH AEEGEDRFAD LCAVGSPFAR ASLKSGKTES SSYFRRKEKM FRFFIRRMVK
     AQSFYWVVLC VVALNTLCVA MVHYNQPRRL TTTLYFAEFV FLGLFLTEMS LKMYGLGPRS
     YFRSSFNCFD FGVIVGSVFE VVWAAIKPGS SFGISVLRAL RLLRIFKVTK YWSSLRNLVV
     SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP AAILTVFQIL
     TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK
     DEEEMEEAAN QKLALQKAKE VAEVSPMSAA NISIAARQQN SAKARSVWEQ RASQLRLQNL
     RASCEALYSE MDPEERLRFA TTRHLRPDMK THLDRPLVVE LGRDGARGPV GGKARPEAAE
     APEGVDPPRR HHRHRDKDKT PAAGDQDRAE APKAESGEPG AREERPRPHR SHSKEAAGPP
     EARSERGRGP GPEGGRRHHR RGSPEEAAER EPRRHRAHRH QDPSKECAGA KGERRARHRG
     GPRAGPREAE SGEEPARRHR ARHKAQPAHE AVEKEATEKE AEIVEADKEK ELRNHQPREP
     HCDLETSGTV TVGPMHTLPS TCLQKVEEQP EDADNQRNVT RMGSQPPDPN TIVHIPVMLT
     GPPGEATVVP SGNVDLESQA EGKKEVEADD VMRSGPRPIV PYSSMFCLSP TNLLRRFCHY
     IVTMRYFEMV ILVVIALSSI ALAAEDPVRT DSPRNNALKY LDYIFTGVFT FEMVIKMIDL
     GLLLHPGAYF RDLWNILDFI VVSGALVAFA FSGSKGKDIN TIKSLRVLRV LRPLKTIKRL
     PKLKAVFDCV VNSLKNVLNI LIVYMLFMFI FAVIAVQLFK GKFFYCTDES KELERDCRGQ
     YLDYEKEEVE AQPRQWKKYD FHYDNVLWAL LTLFTVSTGE GWPMVLKHSV DATYEEQGPS
     PGYRMELSIF YVVYFVVFPF FFVNIFVALI IITFQEQGDK VMSECSLEKN ERACIDFAIS
     AKPLTRYMPQ NRQSFQYKTW TFVVSPPFEY FIMAMIALNT VVLMMKFYDA PYEYELMLKC
     LNIVFTSMFS MECVLKIIAF GVLNYFRDAW NVFDFVTVLG SITDILVTEI ANNFINLSFL
     RLFRAARLIK LLRQGYTIRI LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG MQVFGNIALD
     DDTSINRHNN FRTFLQALML LFRCVVRSAQ ANLSCLSNQA CDEQAHATEC GSDFAYFYFV
     SFIFLCSFLV LTHLDEFIRV WAEYDPAACC RIHYKDMYSL LRCIAPPVGL GKNCPRRLAY
     KRLVRMNMPI SNEDMTVHFT STLMALIRTA LEIKLAPAAT SKHQCDEISF VGPIMPQIVN
     FCWTWLGYHP NKPDEMTVGK VYAALMIFDF YKQNKTTRDQ MQQAPGGLSQ MGPVSLFHPL
     KATVEQTQPA VLRGARVFLR QKSSTSLSNG GESVCLLCHR QNQESGIKES VSWGTQRTQD
     APHEARPPLE RGHSTEIPVG RSGALAVDVQ MQSITRRGPD GEPQPGLESQ GRAASMPRLA
     AETQPVTDAS PMKRSISTLA QRPRGTHLCS TTPDRPPPSQ ASHHHHHRCH RRRDRKQRSL
     EKGPSLSADM DGAPSSAAGP GLPPGEGPTG CRRERERRQE RGRSQERRQP SSSSSEKQRF
     YSCDRFGGRE PPKPKPSLSS HPTSPTAGQE PGPHPQGSGS VNGSPLLSTS GASTPGRGGR
     RQLPQTPLTP RPSITYKTAN SSPIHFAGAQ TSLPAFSPGR LSRGLSEHNA LLQRDPLSQP
     LAPGSRIGSD PYLGQRLDSE ASVHALPEDT LTFEEAVATN SGRSSRTSYV SSLTSQSHPL
     RRVPNGYHCT LGLSSGGRAR HSYHHPDQDH WC
//
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