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Database: UniProt
Entry: H2QY88_PANTR
LinkDB: H2QY88_PANTR
Original site: H2QY88_PANTR 
ID   H2QY88_PANTR            Unreviewed;      1888 AA.
AC   H2QY88;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-SEP-2017, entry version 39.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSPTRP00000037005};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000037005, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000037005, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000037005}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000037005}.
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DR   EMBL; AACZ03070662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03070663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03070664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03070665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03070666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03070667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03070668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03070669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03070670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03070671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000037005; -.
DR   PaxDb; H2QY88; -.
DR   Ensembl; ENSPTRT00000040047; ENSPTRP00000037005; ENSPTRG00000021608.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H2QY88; -.
DR   OMA; DSPRNNA; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000002277; Chromosome 9.
DR   Bgee; ENSPTRG00000021608; -.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF246; PTHR10037:SF246; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     40     58       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     70     90       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    165    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    243    265       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    702    720       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    740    760       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    772    790       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    833    855       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    945    970       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1026   1044       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1056   1079       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1085   1104       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1149   1176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1235   1258       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1274   1309       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      268    294       {ECO:0000256|SAM:Coils}.
FT   COILED      545    570       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1888 AA;  212440 MW;  5EBBB766195B24B7 CRC64;
     GSPFARASLK SGKTESSSYF RRKEKMFRFF IRRMVKAQSF YWVVLCVVAL NTLCVAMVHY
     NQPRRLTTTL YFAEFVFLGL FLTEMSLKMY GLGPRSYFRS SFNCFDFGVS ERPDQGPRLY
     XXXXIQLLWD RVLRALRLLP TFKVTKYWSS LRNLVVSLLN SMKSIISLLF LLFLFIVVFA
     LLGMQLFGGQ FNFQDETPTT NFDTFPAAIL TVFQILTGED WNAVMYHGIE SQGGVSKGMF
     SSFYFIVLTL FGNYTLLNVF LAIAVDNLAN AQELTKDEEE MEEAANQKLA LQKAKEVAEV
     SPMSAANISI AARQQNSAKA RSVWEQRASQ LRLQNLRASC EALYSEMDPE ERLRFATTRH
     LRPDMKTHLD RPLVVELGRD GARGPVGGKA RPEAAEAPEG VDPPRRHHRH RDKDKTPAAG
     DQDRAEAPKA ESGEPGAREE RPRPHRSHSK EAAGPPEARS ERGRGPGPEG GRRHHRRGSP
     EEAAEREPRR HRAHRHQDPS KECAGAKGER RARHRGGPRA GPREAESGEE PARRHRARHK
     AQPAHEAVEK EATEKEAEIV EADKEKELRN HQPREPHCDL ETSGTVTVGP MHTLPSTCLQ
     KVEEQPEDAD NQRNVTRMGS QPPDPNTIVH IPVMLTGPPG EATVVPSGNV DLESQAEGKK
     EVEADDVMRS GPRPIVPYSS MFCLSPTNLL RRFCHYIVTM RYFEMVILVV IALSSIALAA
     EDPVRTDSPR NNALKYLDYI FTGVFTFEMV IKMIDLGLLL HPGAYFRDLW NILDFIVVSG
     ALVAFAFSGS KGKDINTIKS LRVLRVLRPL KTIKRLPKLK AVFDCVVNSL KNVLNILIVY
     MLFMFIFAVI AVQLFKGKFF YCTDESKELE RDCRGQYLDY EKEEVEAQPR QWKKYDFHYD
     NVLWALLTLF TVSTGEGWPM VLKHSVDATY EEQGPSPGYR MELSIFYVVY FVVFPFFFVN
     IFVALIIITF QEQGDKVMSE CSLEKNERAC IDFAISAKPL TRYMPQNRQS FQYKTWTFVV
     SPPFEYFIMA MIALNTVVLM MKFYDAPYEY ELMLKCLNIV FTSMFSMECV LKIIAFGVLN
     YFRDAWNVFD FVTVLGSITD ILVTEIAQNN FINLSFLRLF RAARLIKLLR QGYTIRILLW
     TFVQSFKALP YVCLLIAMLF FIYAIIGMQV FGNIALDDDT SINRHNNFRT FLQALMLLFR
     SATGEAWHEI MLSCLSNQAC DEQANATECG SDFAYFYFVS FIFLCSFLML NLFVAVIMDN
     FEYLTRDSSI LGPHHLDEFI RVWAEYDPAA CGRISYNDMF EMLKHMSPLW GLGKKCPARV
     AYKRLVRMNM PISNEDMTVH FTSTLMALIR TALEIKLAPA GTKQHQCDAE LRKEISVVWA
     NLPQKTLDLL VPPHKPDEMT VGKVYAALMI FDFYKQNKTT RDQMQQAPGG LSQMGPVSLF
     HPLKATVEQT QPAVLRGARV FLRQKSSTSL SNGGAIQNQE SGIKESVSWG TQRTQDAPHE
     ARPPLERGHS TEIPVGRSGA LAVDVQMQSI TRRGPDGEPQ PGLESQGRAA SMPRLAAETQ
     PVTDASPMKR SISTLAQRPR GTHLCSTTPD RPPPSQASHH HHHRCHRRRD RKQRSLEKGP
     SLSADMDGAP SSAAGPGLPP GEGPTGCRRE RERRQERGRS QERRQPSSSS SEKQRFYSCD
     RFGGREPPKP KPSLSSHPTS PTAGQEPGPH PQGSGSVNGS PLLSTSGAST PGRGGRRQLP
     QTPLTPRPSI TYKTANSSPI HFAGAQTSLP AFSPGRLSRG LSEHNALLQR DPLSQPLAPG
     SRIGSDPYLG QRLDSEASVH ALPEDTLTFE EAVATNSGRS SRTSYVSSLT SQSHPLRRVP
     NGYHCTLGLS SGGRARHSYH HPDQDHWC
//
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