ID H2QYU4_PANTR Unreviewed; 263 AA.
AC H2QYU4; A0A2J8KK03;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Integral membrane protein 2 {ECO:0000256|RuleBase:RU367061};
GN Name=ITM2A {ECO:0000313|EMBL:JAA17605.1,
GN ECO:0000313|Ensembl:ENSPTRP00000037936.3, ECO:0000313|VGNC:VGNC:1367};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000037936.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000037936.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA17605.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA36056.1}, and Smooth
RC vascular {ECO:0000313|EMBL:JAA17605.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000037936.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU367061}; Single-
CC pass type II membrane protein {ECO:0000256|RuleBase:RU367061}.
CC -!- SIMILARITY: Belongs to the ITM2 family. {ECO:0000256|ARBA:ARBA00006794,
CC ECO:0000256|RuleBase:RU367061}.
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DR EMBL; AC195665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABF01004540; JAA17605.1; -; mRNA.
DR EMBL; GABE01008683; JAA36056.1; -; mRNA.
DR RefSeq; XP_001145755.2; XM_001145755.4.
DR PaxDb; 9598-ENSPTRP00000037936; -.
DR Ensembl; ENSPTRT00000041064.4; ENSPTRP00000037936.3; ENSPTRG00000022057.4.
DR GeneID; 742537; -.
DR KEGG; ptr:742537; -.
DR CTD; 9452; -.
DR VGNC; VGNC:1367; ITM2A.
DR eggNOG; KOG4681; Eukaryota.
DR GeneTree; ENSGT00950000183115; -.
DR HOGENOM; CLU_074596_0_0_1; -.
DR OMA; ENDDNGM; -.
DR OrthoDB; 3664639at2759; -.
DR TreeFam; TF317770; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000022057; Expressed in Brodmann (1909) area 10 and 20 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001540; F:amyloid-beta binding; IBA:GO_Central.
DR GO; GO:0042985; P:negative regulation of amyloid precursor protein biosynthetic process; IBA:GO_Central.
DR GO; GO:0002317; P:plasma cell differentiation; IEA:Ensembl.
DR InterPro; IPR007084; BRICHOS_dom.
DR InterPro; IPR040145; ITM2.
DR PANTHER; PTHR10962:SF7; INTEGRAL MEMBRANE PROTEIN 2A; 1.
DR PANTHER; PTHR10962; INTEGRAL TRANSMEMBRANE PROTEIN 2; 1.
DR Pfam; PF04089; BRICHOS; 1.
DR SMART; SM01039; BRICHOS; 1.
DR PROSITE; PS50869; BRICHOS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|RuleBase:RU367061};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367061};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal-anchor {ECO:0000256|RuleBase:RU367061};
KW Transmembrane {ECO:0000256|RuleBase:RU367061};
KW Transmembrane helix {ECO:0000256|RuleBase:RU367061}.
FT TRANSMEM 54..78
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367061"
FT DOMAIN 133..227
FT /note="BRICHOS"
FT /evidence="ECO:0000259|PROSITE:PS50869"
SQ SEQUENCE 263 AA; 29741 MW; C565E2F80FE223BD CRC64;
MVKIAFNTPT AVQKEEARQD VEALLSRTVR TQILTGKELR VATQEKEGSS GRCMLTLLGL
SFILAGLIVG GACIYKYFMP KSTIYRGEMC FFDSEDPANS LRGGEPNFLP VTEEADIRED
DNIAIIDVPV PSFSDSDPAA IIHDFEKGMT AYLDLLLGNC YLMPLNTSIV MPPKNLVELF
GKLASGRYLP QTYVVREDLV AVEEIRDVSN LGIFIYQLCN NRKSFRLRRR DLLLGFNKRA
IDKCWKIRHF PNEFIVETKI CQE
//
