ID   H2QZG6_PANTR            Unreviewed;       483 AA.
AC   H2QZG6; A0A2J8KX36;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 6 {ECO:0000313|Ensembl:ENSPTRP00000038971.5};
GN   Name=ENTPD6 {ECO:0000313|Ensembl:ENSPTRP00000038971.5,
GN   ECO:0000313|VGNC:VGNC:9846};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000038971.5, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000038971.5, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000038971.5}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   EMBL; AACZ04064851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_009435225.1; XM_009436950.2.
DR   RefSeq; XP_009435226.1; XM_009436951.2.
DR   AlphaFoldDB; H2QZG6; -.
DR   Ensembl; ENSPTRT00000042064.5; ENSPTRP00000038971.5; ENSPTRG00000013338.7.
DR   GeneID; 458146; -.
DR   CTD; 955; -.
DR   VGNC; VGNC:9846; ENTPD6.
DR   eggNOG; KOG1385; Eukaryota.
DR   GeneTree; ENSGT01100000263540; -.
DR   HOGENOM; CLU_010246_0_2_1; -.
DR   OrthoDB; 180318at2759; -.
DR   TreeFam; TF315029; -.
DR   Proteomes; UP000002277; Chromosome 20.
DR   Bgee; ENSPTRG00000013338; Expressed in dorsolateral prefrontal cortex and 21 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF99; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        37..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        223
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         253..257
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   483 AA;  53077 MW;  211699EE796C1FD9 CRC64;
     MKKGIRYETS RKTSYSFQPQ HGPWQTRMRK ISNHGSLRVA KVAYPLGLCV GVFIYVAYIK
     WHRATATQAF FSITRAAPGA RWGQQAHSPL GTAADGHEVF YGIMFDAGST GTRVHVFQFT
     RPPRETPTLT HETFKALKPG LSAYADDVEK SAQGIQELLD VAKQDIPFDF WKATPLVLKA
     TAGLRLLPGE KAQKLLQKVK EVFKASPFLV GDDCVSIMNG TDEGVSAWIT INFLTGSLKT
     PGGSSVGMLD LGGGSTQIAF LPRVEGTLQA SPPGYLTALR MFNRTYKLYS YSYLGLGLMS
     ARLAILGGVE GQPAKDGKEL VSPCLSPSFK GEWEHAEVTY RVSGQKAVAS LHELCAARVS
     EVLQNRVHRT EEVKHVDFYA FSYYYDLAAG VGLIDAEKGG SLVVGDFEIA AKYVCRTLET
     QPQSSPFACM DLTYVSLLLQ EFGFPRSKVL KLTRKIDNVE TSWALGAIFH YIDSLNRQKS
     PAS
//