ID H2R0L1_PANTR Unreviewed; 690 AA.
AC H2R0L1; A0A2J8MYH1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Rabphilin 3A {ECO:0000313|Ensembl:ENSPTRP00000040887.4};
GN Name=RPH3A {ECO:0000313|Ensembl:ENSPTRP00000040887.4,
GN ECO:0000313|VGNC:VGNC:5575};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000040887.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000040887.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000040887.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04070338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2R0L1; -.
DR Ensembl; ENSPTRT00000046924.4; ENSPTRP00000040887.4; ENSPTRG00000005476.6.
DR VGNC; VGNC:5575; RPH3A.
DR eggNOG; KOG1013; Eukaryota.
DR GeneTree; ENSGT00940000157468; -.
DR HOGENOM; CLU_011461_2_0_1; -.
DR TreeFam; TF351844; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000005476; Expressed in Brodmann (1909) area 10 and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04035; C2A_Rabphilin_Doc2; 1.
DR CDD; cd08384; C2B_Rabphilin_Doc2; 1.
DR CDD; cd15762; FYVE_RP3A; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR028698; FYVE_RPH3A.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR043566; Rabphilin/DOC2/Noc2.
DR InterPro; IPR047022; Rabphilin_Doc2_C2A.
DR InterPro; IPR001565; Synaptotagmin.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45729; RABPHILIN, ISOFORM A; 1.
DR PANTHER; PTHR45729:SF3; RABPHILIN-3A; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 40..156
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 88..144
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 388..510
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 546..679
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 24..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..193
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..297
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 76360 MW; B645E4A27D8F48F7 CRC64;
MTDTVFSNSS NRWMYPSDRP LQSKLQAGWS VHPGGQPDRQ RKQEELTDEE KEIINRVIAR
AEKMEEMEQE RIGRLVDRLE NMRKNVAGDG VNRCILCGEQ LGMLGSACVV CEDCKKNVCT
KCGVETNNRL HSVWLCKICI EQREVWKRSG AWFFKGFPKQ VLPQPMPIKK TKPQQPVSEP
AAPEQPAPEP KHPARAPARG DSEDRRGPGQ KTGPDPASAP GRGNYGPPVR RASEARMSSS
SRDSESWDHS GGAGDSSRSP AGLRRANSVQ ASRPAPGSVQ SPAPPQPGQP GTPGGSRPGP
GPAGRFPDQK PEVAPSDPGT TAPPREERTG GVGGYAAVGA REDRMSHPSG PYSQASAAAP
QPAAARQPPP PEEEEEEANS YDSDEATTLG ALEFSLLYDQ DNSSLQCTII KAKGLKPMDS
NGLADPYVKL HLLPGASKSN KLRTKTLRNT RNPIWNETLV YHGITDEDMQ RKTLRISVCD
EDKFGHNEFI GETRFSLKKL KPNQRKNFNI CLERVIPMKR AGTTGSARGM ALYEEEQVER
VGDIEERGKI LVSLMYSTQQ GGLIVGIIRC VHLAAMDANG YSDPFVKLWL KPDMGKKAKH
KTQIKKKTLN PEFNEEFFYD IKHSDLAKKS LDISVWDYDI GKSNDYIGGC QLGISAKGER
LKHWYECLKN KDKKIERWHQ LQNENHVSSD
//
