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Database: UniProt
Entry: H2R0U9_PANTR
LinkDB: H2R0U9_PANTR
Original site: H2R0U9_PANTR 
ID   H2R0U9_PANTR            Unreviewed;      4913 AA.
AC   H2R0U9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   25-APR-2018, entry version 52.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSPTRP00000041283};
GN   Name=RYR2 {ECO:0000313|VGNC:VGNC:6990};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000041283, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000041283, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000041283}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AACZ04026659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04026660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04026661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000041283; -.
DR   PaxDb; H2R0U9; -.
DR   Ensembl; ENSPTRT00000049430; ENSPTRP00000041283; ENSPTRG00000002149.
DR   VGNC; VGNC:6990; RYR2.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H2R0U9; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000002277; Chromosome 1.
DR   Bgee; ENSPTRG00000002149; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4233   4252       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4446   4466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4520   4539       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4656   4677       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4714   4735       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4790   4813       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       89    144       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      151    196       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      204    259       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      265    322       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      330    387       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      578    788       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1004   1201       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1316   1541       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3976   4011       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      451    471       {ECO:0000256|SAM:Coils}.
FT   COILED     3037   3057       {ECO:0000256|SAM:Coils}.
FT   COILED     3302   3322       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4913 AA;  558006 MW;  0E2A79F483FC5DD6 CRC64;
     DDEVVLQCTA TIHKEQQKLC LAAEGFGNRL CFLESTSNSK NVPPDLSICT FVLEQSLSVR
     ALQEMLANTV EKSEGQVDVE KWTAQGGGHR TLLYGHAILL RHSYSGMYLC CLSTSRSSTD
     KLAFDVGLQE DTTGEACWWT IHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSYGNGSL
     HVDAAFQQTL WSVAPISSGS EAAQGYLIGG DVLRLLHGHM DECLTVPSGE HGEEQRRTVH
     YEGGAVSVHA RSLWRLETLR VAWSGSHIRW GQPFRLRHVT TGKYLSLMED KNLLLMDKEK
     ADVKSTAFTF RSSKEKLDVG VRKEVDGMGT SEIKYGDSVC YIQHVDTGLW LTYQSVDVKS
     VRMGSIQRKA IMHHEGHMDD GISLSRSQHE ESRTARVIRS TVFLFNRFIR GLDALSKKAK
     ASTVDLPIES VSLSLQDLIG YFHPPDEHLE HEDKQNRLRA LKNRQNLFQE EGMINLVLEC
     IDRLHVYSSA AHFADVAGRE AGESWKSILN SLYELLAALI RGNRKNCAQF SGSLDWLISR
     LERLEASSGI LEVLHCVLVE SPEALNIIKE GHIKSIISLL DKHGRNHKVL DVLCSLCVCH
     GVAVRSNQHL ICDNLLPGRD LLLQTRLVNH VSSMRPNIFL GVSEGSAQYK KWYYELMVDH
     TEPFVTAEAT HLRVGWASTE GYSPYPGGGE EWGGNGVGDD LFSYGFDGLH LWSGCIARTV
     SSPNQHLLRT DDVISCCLDL SAPSISFRIN GQPVQGMFEN FNIDGLFFPV VSFSAGIKVR
     FLLGGRHGEF KFLPPPGYAP CYEAVLPKEK LKVEHSREYK QERTYTRDLL GPTVSLTQAA
     FTPIPVDTSQ IVLPPHLERI REKLAENIHE LWVMNKIELG WQYGPVRDDN KRQHPCLVEF
     CKLPEQERNY NLQMSLETLK TLLALGCHVG ISDEHAEDKV KKMKLPKNYQ LTSGYKPAPM
     DLSFIKLTPS QEAMVDKLAE NAHNVWARDR IRQGWTYGIQ QDVKNRRNPR LVPYTLLDDR
     TKKSNKDSLR EAVRTLLGYG YNLEAPDQDH AARAEVCSGT GERFRIFRAE KTYAVKAGRW
     YFEFETVTAG DMRVGWSRPG CQPDQELGSD ERAFAFDGFK AQRWHQGNEH YGRSWQAGDV
     VGCMVDMNEH TMMFTLNGEI LLDDSGSELA FKDFDVGDGF IPVCSLGVAQ VGRMNFGKDV
     STLKYFTICG LQEGYEPFAV NTNRDITMWL SKRLPQFLQV PSNHEHIEVT RIDGTIDSSP
     CLKVTQKSFG SQNSNTDIMF YRLSMPIECA EVFSKTVAGG LPGAGLFGPK NDLEDYDADS
     DFEVLMKTAH GHLVPDRVDK DKEATKPEFN NHKDYAQEKP SRLKQRFLLR RTKPDYSTSH
     SARLTEDVLA DDRDDYDFLM QTSTYYYSVR IFPGQEPANV WVGWITSDFH QYDTGFDLDR
     VRTVTVTLGD EKGKVHESIK RSNCYMVCAG ESMSPGQGRN NNGLEIGCVV DAASGLLTFI
     ANGKELSTYY QVEPSTKLFP AVFAQATSPN VFQFELGRIK NVMPLSAGLF KSEHKNPVPQ
     CPPRLHVQFL SHVLWSRMPN QFLKVDVSRI SERQGWLVQC LDPLQFMSLH IPEENRSVDI
     LELTEQEELL KFHYHTLRLY SAVCALGNHR VAHALCSHVD EPQLLYAIEN KYMPGLLRAG
     YYDLLIDIHL SSYATARLMM NNEYIVPMTE ETKSITLFPD ENKKHGLPGI GLSTSLRPRM
     QFSSPSFVSI SNECYQYSPE FPLDILKSKT IQMLTEAVKE GSLHARDPVG GTTEFLFVPL
     IKLFYTLLIM GIFHNEDLKH ILQLIEPSVF KEAATPEEES DTLEKELSVD DAKLQGAGEE
     EAKGGKRPKE GLLQMKLPEP VKLQMCLLLQ YLCDCQVRHR IEAIVAFSDD FVAKLQDNQR
     FRYNEVMQAL NMSAALTARK TKEFRSPPQE QINMLLNFKD DKSECPCPEE IRDQLLDFHE
     DLMTHCGIEL DEDGSLDGNS DLTIRGRLLS LVEKVTYLKK KQAEKPVESD SKKSSTLQQL
     ISETMVRWAQ ESVIEDPELV RAMFVLLHRQ YDGIGGLVRA LPKTYTINGV SVEDTINLLA
     SLGQIRSLLS VRMGKEEEKL MIRGLGDIMN NKVFYQHPNL MRALGMHETV MEVMVNVLGG
     GESKEITFPK MVANCCRFLC YFCRISRQNQ KAMFDHLSYL LENSSVGLAS PAMRGSTPLD
     VAAASVMDNN ELALALREPD LEKVVRYLAG CGLQSCQMLV SKGYPDIGWN PVEGERYLDF
     LRFAVFCNGE SVEENANVVV RLLIRRPECF GPALRGEGGN GLLAAMEEAI KIAEDPSRDG
     PSPNSGSSKT LDTEEEEDDT IHMGNAIMTF YSALIDLLGR CAPEMHLIHA GKGEAIRIRS
     ILRSLIPLGD LVGVISIAFQ MPTIAKDGNV VEPDMSAGFC PDHKAAMVLF LDRVYGIEVQ
     DFLLHLLEVG FLPDLRAAAS LDTAALSATD MALALNRYLC TAVLPLLTRC APLFAGTEHH
     ASLIDSLLHT VYRLSKGCSL TKAQRDSIEV CLLSICGQLR PSMMQHLLRR LVFDVPLLNE
     HAKMPLKLLT NHYERCWKYY CLPGGWGNFG AASEEELHLS RKLFWGIFDA LSQKKYEQEL
     FKLALPCLSA VAGALPPDYM ESNYVSMMEK QSSMDSEGNF NPQPVDTSNI TIPEKLEYFI
     NKYAEHSHDK WSMDKLANGW IYGEIYSDSS KVQPLMKPYK LLSEKEKEIY RWPIKESLKT
     MLAWGWRIER TREGDSMALY NRTRRISQTS QVSVDAAHGY SPRAIDMSNV TLSRDLHAMA
     EMMAENYHNI WAKKKKMELE SKGGGNHPLL VPYDTLTAKE KAKDREKAQD ILKFLQINGY
     AVSRGFKDLE LDTPSIEKRF AYSFLQQLIR YVDEAHQYIL EFDGGSRGKG EHFPYEQEIK
     FFAKVVLPLI DQYFKNHRLY FLSAASRPLC SGGHASNKEK EMVTSLFCKL GVLVRHRISL
     FGNDATSIVN CLHILGQTLD ARTVMKTGLE SVKSALRAFL DNAAEDLEKT MENLKQGQFT
     HTRNQPKGVT QIINYTTVAL LPMLSSLFEH IGQHQFGEDL ILEDVQVSCY RILTSLYALG
     TSKSIYVERQ RSALGECLAA FAGAFPIAFL ETHLDKHNIY SIYNTKSSRE RAALSLPTNV
     EDVCPNIPSL EKLMEEIVEL AESGIRYTQM PHVMEVILPM LCSYMSRWWE HGPENNPERA
     EMCCTALNSE HMNTLLGNIL KIIYNNLGID EGAWMKRLAV FSQPIINKVK PQLLKTHFLP
     LMEKLKKKAA TVVSEEDHLK AEARGDMSEA ELLILDEFTT LKYLYPFLII LIYQINTYLC
     KNLQVLLVLT EISFATSQNF KREEQNFVVQ NEINNMSFLI TDTKSKMSKA AVSDQERKKM
     KRKGDRYSMQ TSLIVAALKR LLPIGLNICA PGDQELIALA KNRFSLKDTE DEVRDIIRSN
     IHLQGKLEDP AIRWQMALYK DLPNRTDDTS DPEKTVERVL DIANVLFHLE QKSKRVGRRH
     YCLGSTVEHP QRSKKAVWHK LLSKQRKRAV VACFRMAPLY NLPRHRAVNL FLQGYEKSWI
     ETEEHYFEDK LIEDLAKPGA EPPEEDEGTK RVDPLHQLIL LFSRTALTEK CKLEEDFLYM
     AYADIMAKEK EMEKQKLLYQ QARLHDRGAA EMVLQTISAS KGETGPMVAA TLKLGIAILN
     GGNSTVQQKM LDYLKEKKDV GFFQSLAGLM QSCSVLDLNA FERQNKAEGL GMVTEEGSGE
     KVLQDDEFTC DLFRFLQLLC EGHNSDFQNY LRTQTGNNTT VNIIISTVDY LLRVQESISD
     FYWYYSGKDV IDEQGQRNFS KAIQVAKQVF NTLTEYIQGP CTGNQQSLAH SRLWDAVVGF
     LHVFAHMQMK LSQDSSQIEL LKELMDLQKD MVVMLLSMLE GNVVNGTIGK QMVDMLVESS
     NNVEMILKFF DMFLKLKDLT SSDTFKEYDP DGKGVISKRD FHKAMESHKH YTQSETEFLL
     SCAETDENET LDYEEFVKRF HEPAKDIGFN VAVLLTNLSE HMPNDTRLQT FLELAESVLN
     YFQPFLGRIE IMGSAKRIER VYFEISESSR TQWEKPQVKE SKRQFIFDVV NEGGEKEKME
     LFVNFCEDTI FEMQLAAQIS ESDLNGRSAN KEESEKERPE EQGPRMAFFS ILTVKSALFA
     LRYNILTLMR MLSLKSLKKQ MKKVKKMTVK DMVTAFFSSY WSIFMTLLHF VASVFRGFSR
     IICSLLLGGS LVEGAKKIKV AELLANMPDP TQDEVRGDGE EGERKPLEAA LPSEDLTDLK
     ELTEESDLLS DIFGLDLKRE GGQYKLIPHN PNAGLSDLMS NPVPMPEVQE KFQFFSFWRA
     YVLFVCFHRG EDGEKEEKAK EDKGKQKLRQ LHTHRYGEPE VPESAFWKKI IAYQQKLLNY
     FARNFYNMRM LALFVAFAIN FILLFYKVST SSVVEGKELP TRSSSENAKV TSLDSSSHRI
     IAVHYVLEES SGYMEPTLRI LAILHTVISF FCIIGYYCLK VPLVIFKREK EVARKLEFDG
     LYITEQPSED DIKGQWDRLV INTQSFPNNY WDKFVKRKVM DKYGEFYGRD RISELLGMDK
     AALDFSDARE KKKPKKDSSL SAVLNSIDVK YQMWKLGVVF TDNSFLYLAW YMTMSVLGHY
     NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN
     KSEDGDTPDM KCDDMLTCYM FHMYVGVRAG GGIGDEIEDP AGDEYEIYRI IFDITFFFFV
     IVILLAIIQG LIIDAFGELR DQQEQVKEDM ETKCFICGIG NDYFDTVPHG FETHTLQEHN
     LANYLFFLMY LINKDETEHT GQESYVWKMY QERCWEFFPA GDCFRKQYED QLN
//
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