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Database: UniProt
Entry: H2R1K2_PANTR
LinkDB: H2R1K2_PANTR
Original site: H2R1K2_PANTR 
ID   H2R1K2_PANTR            Unreviewed;      2296 AA.
AC   H2R1K2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1A {ECO:0000313|Ensembl:ENSPTRP00000042495};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000042495, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000042495, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000042495}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1A
CC       gives rise to P and/or Q-type calcium currents. P/Q-type calcium
CC       channels belong to the 'high-voltage activated' (HVA) group and
CC       are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-
CC       IVA (omega-Aga-IVA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000042495}.
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DR   EMBL; AACZ03118331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03118332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03118333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03118334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03118335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03118336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03118337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03118338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03118339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03121737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000042495; -.
DR   PaxDb; H2R1K2; -.
DR   Ensembl; ENSPTRT00000048615; ENSPTRP00000042495; ENSPTRG00000010561.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H2R1K2; -.
DR   OMA; EKDCRGK; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000002277; Chromosome 19.
DR   Bgee; ENSPTRG00000010561; -.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:Ensembl.
DR   GO; GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IEA:Ensembl.
DR   GO; GO:0016049; P:cell growth; IEA:Ensembl.
DR   GO; GO:0030644; P:cellular chloride ion homeostasis; IEA:Ensembl.
DR   GO; GO:0021679; P:cerebellar molecular layer development; IEA:Ensembl.
DR   GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IEA:Ensembl.
DR   GO; GO:0021590; P:cerebellum maturation; IEA:Ensembl.
DR   GO; GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
DR   GO; GO:0014051; P:gamma-aminobutyric acid secretion; IEA:Ensembl.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0050883; P:musculoskeletal movement, spinal reflex action; IEA:Ensembl.
DR   GO; GO:0032353; P:negative regulation of hormone biosynthetic process; IEA:Ensembl.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:Ensembl.
DR   GO; GO:0007270; P:neuron-neuron synaptic transmission; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0043113; P:receptor clustering; IEA:Ensembl.
DR   GO; GO:0014056; P:regulation of acetylcholine secretion, neurotransmission; IEA:Ensembl.
DR   GO; GO:0050770; P:regulation of axonogenesis; IEA:Ensembl.
DR   GO; GO:0017158; P:regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
DR   GO; GO:0031335; P:regulation of sulfur amino acid metabolic process; IEA:Ensembl.
DR   GO; GO:0060024; P:rhythmic synaptic transmission; IEA:Ensembl.
DR   GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
DR   GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR   GO; GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
DR   GO; GO:0019226; P:transmission of nerve impulse; IEA:Ensembl.
DR   GO; GO:0021750; P:vestibular nucleus development; IEA:Ensembl.
DR   InterPro; IPR005448; CACNA1A.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01632; PQVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    102    119       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    139    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    337    359       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    519    539       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    614    636       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    690    714       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1243   1262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1282   1303       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1315   1332       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1377   1399       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1489   1514       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1570   1588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1600   1623       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1691   1709       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1787   1811       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1914   1948       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      710    746       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2296 AA;  258242 MW;  7D289C0EBFC39A97 CRC64;
     MARFGDEMPA RYGGGGSGAA AGVVVGAGGG RGAGGSRQGG QPGAQRMYKQ SMAQRARTMA
     LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPPF EYMILATIIA NCIVLALEQH
     LPDDDKTPMS ERLDDTEPYF IGIFCFEAGI KIIALGFAFH KGSYLRNGWN VMDFVVVLTG
     ILATVGTEFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILIF
     AIIGLEFYMG KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGITQ
     FDNILFAVLT VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF MLNLVLGVLS
     GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAE EVILAEDDTD GEQRHPFDGA
     LRRTTIKKSK TDLLNPEEAE DQLADIASVG SPFARASIKS AKLENSTFFH KKERRMRFYI
     RRMVKTQAFY WTVLSLVALN TLCVAIVHYN QPEWLSDFLY YAEFIFLGLF MSEMFIKMYG
     LGTRPYFHSS FNCFDCGVII GSIFEVIWAV IKPGTSFGIS VLRALRLLRI FKVTKYWASL
     RNLVVSLLNS MKSIISLLFL LFLFIVVFAL LGMQLFGGQF NFDEGTPPTN FDTFPAAIMT
     VFQILTGEDW NEVMYDGIKS QGGVQGGMVF SIYFIVLTLF GNYTLLNVFL AIAVDNLANA
     QELTKDEQEE EEAANQKLAL QKAKEVAEVS PLSAANMSIA VKEQQKNQKP AKSVWEQRTS
     EMRKQNLLAS REALYNEMDP DERWKSAYTR HLRPDMKTHL DRPLVVDPQE NRNNNTNKSR
     AAEPTVDQRL GQQRAEDFLR KQARYHDRAR DPSGSAGLDA RRPWAGSQEA ELSREGPYGR
     ESDHHAREGS LEQPGFWEGE AERGKAGDPH RRHVHRQGGS RESRSGSPCT GADGEHRRHR
     AHRRPGEEGP EDKAERRARH REGSRPARGG EGEGEGPDGG ERRRRHRHGA PATYEGDARR
     EDKERRHRRR KENQGSGVPV SGPNLSTTRP IQQDLGRQDP PLAEDIDNMK NNKLATAESA
     APHGSLGHAG LPQSPAKMGN STDPGPTPAI PAMATNPQNA ASRRTPNNPG NPSNPGPPKT
     PENSLIVTNP SGTQTNSAKT ARKPDHTTVD IPPACPPPLN HTVVQVNKNA NPDPLPKKEE
     EKKEEEEDDR GEDGPKPMPP YSSMFILSTT NPLRRLCHYI LNLRYFEMCI LMVIAMSSIA
     LAAEDPVQPN APRNNVLRYF DYVFTGVFTF EMVIKMIDLG LVLHQGAYFR DLWNILDFIV
     VSGALVAFAF TGNSKGKDIN TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV VNSLKNVFNI
     LIVYMLFMFI FAVVAVQLFK GKFFHCTDES KEFEKDCRGK YLLYEKNEVK ARDREWKKYE
     FHYDNVLWAL LTLFTVSTGE GWPQVLKHSV DATFENQGPS PGYRMEMSIF YVVYFVVFPF
     FFVNIFVALI IITFQEQGDK MMEEYSLEKN ERACIDFAIS AKPLTRHMPQ NKQSFQYRMW
     QFVVSPPFEY TIMAMIALNT IVLMMKFYGA SVAYENALRV FNIVFTSLFS LECVLKVMAF
     GILNYFRDAW NIFDFVTVLG SITDILVTEF GNNFINLSFL RLFRAARLIK LLRQGYTIRI
     LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG MQVFGNIGID VEDEDSDEDE FQITEHNNFR
     TFFQALMLLF RSATGEAWHN IMLSCLSGKP CDKNSGILTR ECGNEFAYFY FVSFIFLCSF
     LMLNLFVAVI MDNFEYLTRD SSILGPHHLD EYVRVWAEYD PARLLRMDLP VADDNTVHFN
     STLMALIRTA LDIKIAKGGA DKQQMDAELR KEMMAIWPNL SQKTLDLLVT PHKSTDLTVG
     KIYAAMMIME YYRQSKAKKL QAMREEQDRT PLMFQRMEPP SPTQEGGPGQ NALPSTQLDP
     GGALMAHESG LKESPSWVTQ RAQEMFQKTG TWSPEQGPPT DMPNSQPNSQ SVEMREMGRD
     GYSDSEHYLP MEGQGRAASM PRLPAENQST PRRGRRQLPQ TPSTPRPHVS YSPVIRKAGG
     SGPPQQQQQQ QQQQQAVARP GRAATSGPRR YPGPTAEPLA GDRPPTGGHS SGRSPRMERR
     VPGPARSESP RACRHGGARW PASGPHVSEG PPGPRHHGYY RGSDYDEADG PGSGGGEEAM
     ARAYDAPPPV RHASSGATGR SPRTPRASGP ACASPSRHGR RLPNGYYPAH GLARPRGPGS
     RKGLHEPYSE SDDDWC
//
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