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Database: UniProt
Entry: H2R1K2_PANTR
LinkDB: H2R1K2_PANTR
Original site: H2R1K2_PANTR 
ID   H2R1K2_PANTR            Unreviewed;      2467 AA.
AC   H2R1K2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   25-APR-2018, entry version 43.
DE   RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1A {ECO:0000313|Ensembl:ENSPTRP00000042495,
GN   ECO:0000313|VGNC:VGNC:10912};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000042495, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000042495, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000042495}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1A
CC       gives rise to P and/or Q-type calcium currents. P/Q-type calcium
CC       channels belong to the 'high-voltage activated' (HVA) group and
CC       are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-
CC       IVA (omega-Aga-IVA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; AACZ04030654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ04030655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC192155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000042495; -.
DR   PaxDb; H2R1K2; -.
DR   Ensembl; ENSPTRT00000048615; ENSPTRP00000042495; ENSPTRG00000010561.
DR   VGNC; VGNC:10912; CACNA1A.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H2R1K2; -.
DR   OMA; EKDCRGK; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000002277; Chromosome 19.
DR   Bgee; ENSPTRG00000010561; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005448; CACNA1A.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01632; PQVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     92    112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    124    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    175    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    257    278       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    290    312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    440    459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    471    491       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    566    588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    642    666       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1195   1214       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1234   1255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1267   1284       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1329   1351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1441   1466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1522   1540       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1552   1575       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1643   1661       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1739   1763       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1910   1944       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      320    340       {ECO:0000256|SAM:Coils}.
FT   COILED      662    698       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2467 AA;  277655 MW;  F5B4E013443E2939 CRC64;
     MARFGDEMPA RYGGGGSGAA AGVVVGAGGG RGAGGSRQGG QPGAQRMYKQ SMAQRARTMA
     LYNPIPVRQN CLTVNRSLFL FSEDNVDDTE PYFIGIFCFE AGIKIIALGF AFHKGSYLRN
     GWNVMDFVVV LTGILATVGT EFDLRTLRAV RVLRPLKLVS GIPSLQVVLK SIMKAMIPLL
     QIGLLLFFAI LIFAIIGLEF YMGKFHTTCF EEGTDDIQGE SPAPCGTEEP ARTCPNGTKC
     QPYWEGPNNG ITQFDNILFA VLTVFQCITM EGWTDLLYNS NDASGNTWNW LYFIPLIIIG
     SFFMLNLVLG VLSGEFAKER ERVENRRAFL KLRRQQQIER ELNGYMEWIS KAEEVILAED
     DTDGEQRHPF DALRRTTIKK SKTDLLNPEE AEDQLADIAS VGSPFARASI KSAKLENSTF
     FHKKERRMRF YIRRMVKTQA FYWTVLSLVA LNTLCVAIVH YNQPEWLSDF LYYAEFIFLG
     LFMSEMFIKM YGLGTRPYFH SSFNCFDCGV IIGSIFEVIW AVIKPGTSFG ISVLRALRLL
     RIFKVTKYWA SLRNLVVSLL NSMKSIISLL FLLFLFIVVF ALLGMQLFGG QFNFDEGTPP
     TNFDTFPAAI MTVFQILTGE DWNEVMYDGI KSQGGVQGGM VFSIYFIVLT LFGNYTLLNV
     FLAIAVDNLA NAQELTKDEQ EEEEAANQKL ALQKAKEVAE VSPLSAANMS IAVKEQQKNQ
     KPAKSVWEQR TSEMRKQNLL ASREALYNEM DPDERWKSAY TRHLRPDMKT HLDRPLVVDP
     QENRNNNTNK SRAAEPTVDQ RLGQQRAEDF LRKQARYHDR ARDPSGSAGL DARRPWAGSQ
     EAELSREGPY GRESDHHARE GSLEQPGFWE GEAERGKAGD PHRRHVHRQG GSRESRSGSP
     CTGADGEHRR HRAHRRPGEE GPEDKAERRA RHREGSRPAR GGEGEGEGPD GGERRRRHRH
     GAPATYEGDA RREDKERRHR RRKENQGSGV PVSGPNLSTT RPIQQDLGRQ DPPLAEDIDN
     MKNNKLATAE SAAPHGSLGH AGLPQSPAKM GNSTDPGPTP AIPAMATNPQ NAASRRTPNN
     PGNPSNPGPP KTPENSLIVT NPSGTQTNSA KTARKPDHTT VDIPPACPPP LNHTVVQVNK
     NANPDPLPKK EEEKKEEEED DRGEDGPKPM PPYSSMFILS TTNPLRRLCH YILNLRYFEM
     CILMVIAMSS IALAAEDPVQ PNAPRNNVLR YFDYVFTGVF TFEMVIKMID LGLVLHQGAY
     FRDLWNILDF IVVSGALVAF AFTGNSKGKD INTIKSLRVL RVLRPLKTIK RLPKLKAVFD
     CVVNSLKNVF NILIVYMLFM FIFAVVAVQL FKGKFFHCTD ESKEFEKDCR GKYLLYEKNE
     VKARDREWKK YEFHYDNVLW ALLTLFTVST GEGWPQVLKH SVDATFENQG PSPGYRMEMS
     IFYVVYFVVF PFFFVNIFVA LIIITFQEQG DKMMEEYSLE KNERACIDFA ISAKPLTRHM
     PQNKQSFQYR MWQFVVSPPF EYTIMAMIAL NTIVLMMKFY GASVAYENAL RVFNIVFTSL
     FSLECVLKVM AFGILNYFRD AWNIFDFVTV LGSITDILVT EFGNNFINLS FLRLFRAARL
     IKLLRQGYTI RILLWTFVQS FKALPYVCLL IAMLFFIYAI IGMQVFGNIG IDVEDEDSDE
     DEFQITEHNN FRTFFQALML LFRSATGEAW HNIMLSCLSG KPCDKNSGIL TRECGNEFAY
     FYFVSFIFLC SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEYVRVWAD PCEPIACTNP
     LSSPFSGRIH YKDMYSLLRV ISPPLGLGKK CPHRVACKRL LRMDLPVADD NTVHFNSTLM
     ALIRTALDIK IAKGGADKQQ MDAELRKEMM AIWPNLSQKT LDLLVTPHKS TDLTVGKIYA
     AMMIMEYYRQ SKAKKLQAMR EEQDRTPLMF QRMEPPSPTQ EGGPGQNALP STQLDPGGAL
     MAHESGLKES PSWVTQRAQE MFQKTGTWSP EQGPPTDMPN SQPNSQSVEM REMGRDGYSD
     SEHYLPMEGQ GRAASMPRLP AENQRRRGRP RGNNLSTISD TSPMKRSASV LGPKARRLDD
     YSLERVPPEE NQRHHQRRRD RSHRASERSL GRYTDVDTGL GTDLSMTTQS GDLPSKERDQ
     ERGRPKDRKH RQHHHHHHHH HPPPPDKDRY AQERPDHGRA RARDQRWSRS PSEGREHMAH
     RQGSSSVSGS PAPSTSGTST PRRGRRQLPQ TPSTPRPHVS YSPVIRKAGG SGPPQQQQQQ
     QQQQQQAVAR PGRAATSGPR RYPGPTAEPL AGDRPPTGGH SSGRSPRMER RVPGPARSES
     PRACRHGGAR WPASGPHVSE GPPGPRHHGY YRGSDYDEAD GPGSGGGEEA MARAYDAPPP
     VRHASSGATG RSPRTPRASG PACASPSRHG RRLPNGYYPA HGLARPRGPG SRKGLHEPYS
     ESDDDWC
//
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