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Database: UniProt
Entry: H2R1N2_PANTR
LinkDB: H2R1N2_PANTR
Original site: H2R1N2_PANTR 
ID   H2R1N2_PANTR            Unreviewed;      1956 AA.
AC   H2R1N2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   30-AUG-2017, entry version 48.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN10A {ECO:0000313|Ensembl:ENSPTRP00000042609};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000042609, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000042609, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000042609}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000042609}.
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DR   EMBL; AACZ03024201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03024202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03024203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03024204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03024205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03024206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000042609; -.
DR   PaxDb; H2R1N2; -.
DR   Ensembl; ENSPTRT00000050611; ENSPTRP00000042609; ENSPTRG00000014763.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H2R1N2; -.
DR   OMA; WNIFDCI; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002277; Chromosome 3.
DR   Bgee; ENSPTRG00000014763; -.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086016; P:AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086043; P:bundle of His cell action potential; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:Ensembl.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF263; PTHR10037:SF263; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    146       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    158    177       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    189    210       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    222    243       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    249    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    372    400       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    657    683       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    695    717       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    784    804       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    867    890       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1153   1171       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1192   1208       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1220   1238       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1269   1295       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1394   1418       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1541   1560       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1596   1624       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1699   1722       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    407       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      666    894       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      904   1147       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1151   1427       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1476   1732       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      397    431       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1956 AA;  220488 MW;  2DC6DE1711FD6EF6 CRC64;
     MEFPIGSLET NNFRRFTPES LVEIEKQIAA KQGTKKAREK HREQKDQEEK PRPQLDLKAC
     NQLPKFYGEL PAELIGEPLE DLDPFYSTHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR
     RTAIKVSVHS WFSLFITITI LVNCVCMTRT DLPEKIEYVF TVIYTFEALI KILARGFCLN
     EFTYLRDPWN WLDFSVITLA YVGTAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI
     HSVKKLADVT ILTIFCLSVF ALVGLQLFKG NLKNKCVKND MAVNETTNYS SHRKPDIYIN
     KRGTSDPLLC GNGSDSGHCP DGYICLKTSD NPDFNYTSFD SFAWAFLSLF RLMTQDSWER
     LYQQTLRASG KIYMIFFVLV IFLGSFYLVN LILAVVTMAY EEQNQATTDE IEAKEKKFQE
     ALEMLRKEQE VLAALGIDTT SLHSHNGSPL TSKNASERRH RIKPRVSEGS TEDNKSPRSD
     PYNQRRMSFL GLASGKRRAS HGSVFHFRSP GRDISLPEGV TDDGVFPGDH ESHRGSLLLG
     GGAGQQGPLP RSPLPQPSNP DSRHGEDEHQ LPPTSELAPG AVDVSAFDAG QKKTFLSAEY
     LDEPFRAQRA MSVVSIITSV LEELEESEQK CPPCLTSLAQ KYLIWDCCPM WVKLKTILFG
     LVTDPFAELT ITLCIVVNTI FMAMEHHGMS PTFEAMLQIG NIVFTIFFTA EMVFKIIAFD
     PYYYFQKKWN IFDCIIVTVS LLELGVAKKG SLSVLRSFRL LRVFKLAKSW PTLNTLIKII
     GNSVGALGNL TIILAIIVFV FALVGKQLLG ENYRNNRKNI SAPHEDWPRW HMHDFFHSFL
     IVFRILCGEW IENMWACMEV GQKSICLILF LTVMVLGNLV VLNLFIALLL NSFSADNLTA
     PEDDGEVNNL QVALARIQVF GHRTKQALCS FFSRPCPFPQ PKAEPELVVK LPLSSSKAEN
     HVAANTARGS SGGLQAPRGP RDEHSDFIAN PTVWVSVPIA EGESDLDDLE DDGGEDAQSF
     QQEVIPKGQQ EQLQQVERCG DHLTPRSPGT GTSSEDLAPS LGETWKDESV PQASAEGVDD
     TSSSEGSTVD CPDPEEILRK IPELADDLEE PDDCFTEGCI RHCPCCKVDT TKSPWDVGWQ
     VRKTCYRIVE HSWFESFIIF MILLSSGSLA FEDYYLDQKP TVKALLEYTD RVFTFIFVFE
     MLLKWVAYGF KKYFTNAWCW LDFLIVNISL ISLTAKILEY SEVAPIKALR TLRALRPLRA
     LSRFEGMRVV VDALVGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFWRC INYTDGEFSL
     VPLSIVNNKS DCKIQNSTGS FFWVNVKVNF DNVAMGYLAL LQVATFKGWM DIMYAAVDSR
     EVNMQPKWED NVYMYLYFVI FIIFGGFFTL NLFVGVIIDN FNQQKKKLGG QDIFMTEEQK
     KYYNAMKKLG SKKPQKPIPR PLNKFQGFVF DIVTRQAFDI TIMVLICLNM ITMMVETDDQ
     SEEKTKILGK INQFFVAVFT GECVMKLFAL RQYYFTNGWN VFDFIVVVLS IASLIFSAIL
     KSLQSYFSPT LFRVIRLARI GRILRLIRAA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI
     YSIFGMSSFP HVRWEAGIDD MFNFQTFANS MLCLFQITTS AGWDGLLSPI LNTGPPYCDP
     NLPNSNGTRG DCGSPAVGII FFTTYIIISF LIVVNMYIAV ILENFNVATE ESTEPLSEDD
     FDMFYETWEK FDPEATQFIT FSALSDFADT LSGPLRIPKP NRNILIQMDL PLVPGDKIHC
     LDILFAFTKN VLGESGELDS LKANMEEKFM ATNLSKSSYE PIATTLRWKQ EDISATVIQK
     AYRSYVLHRS MALSNTPCVP RAEEEAASLP DEGFVAFTAN ENCVLPDKSE TASATSFPPS
     YESVTRGLSD RVNMRTSSSI QNEDEATSME LIAPGP
//
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