ID H2R224_PANTR Unreviewed; 125 AA.
AC H2R224; A0A2J8LFK7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=LY6/PLAUR domain containing 2 {ECO:0000313|Ensembl:ENSPTRP00000043286.2};
GN Name=LYPD2 {ECO:0000313|Ensembl:ENSPTRP00000043286.2,
GN ECO:0000313|VGNC:VGNC:14570};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000043286.2, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000043286.2, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000043286.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
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DR EMBL; AACZ04062103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001150013.1; XM_001150013.4.
DR AlphaFoldDB; H2R224; -.
DR STRING; 9598.ENSPTRP00000043286; -.
DR PaxDb; 9598-ENSPTRP00000043286; -.
DR Ensembl; ENSPTRT00000045359.3; ENSPTRP00000043286.2; ENSPTRG00000023992.3.
DR GeneID; 738684; -.
DR KEGG; ptr:738684; -.
DR CTD; 137797; -.
DR VGNC; VGNC:14570; LYPD2.
DR eggNOG; ENOG502SG63; Eukaryota.
DR GeneTree; ENSGT00940000162197; -.
DR HOGENOM; CLU_141358_2_0_1; -.
DR InParanoid; H2R224; -.
DR OMA; RCYVCPE; -.
DR OrthoDB; 3013155at2759; -.
DR TreeFam; TF336080; -.
DR Proteomes; UP000002277; Chromosome 8.
DR Bgee; ENSPTRG00000023992; Expressed in hindlimb stylopod muscle and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; CD59; 1.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR035076; Toxin/TOLIP.
DR PANTHER; PTHR16983; UPAR/LY6 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR16983:SF16; UPAR_LY6 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00087; Toxin_TOLIP; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; Snake toxin-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022622};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022622};
KW Membrane {ECO:0000256|ARBA:ARBA00022622};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..125
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015093274"
FT DOMAIN 23..110
FT /note="UPAR/Ly6"
FT /evidence="ECO:0000259|SMART:SM00134"
SQ SEQUENCE 125 AA; 13168 MW; 5BD4118E1BF2FD8F CRC64;
MRGTRLALLA LVLAACGELA PALHCYVCPE PTGVSDCVTI ATCTTNETMC KTTLYSREIV
YPFQGDSTVT KSCASKCEPS DVDGIGQTRP VSCCNTELCN VDGAPALNSL HCGVLTLLPL
LSLRL
//
