ID H2R373_PANTR Unreviewed; 697 AA.
AC H2R373; K7DCZ6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=PJA2 {ECO:0000313|EMBL:JAA44438.1,
GN ECO:0000313|Ensembl:ENSPTRP00000045022.4, ECO:0000313|VGNC:VGNC:7101};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000045022.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000045022.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA44438.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA44438.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000045022.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR EMBL; AACZ04010044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABE01000301; JAA44438.1; -; mRNA.
DR Ensembl; ENSPTRT00000046199.4; ENSPTRP00000045022.4; ENSPTRG00000022820.4.
DR VGNC; VGNC:7101; PJA2.
DR eggNOG; KOG0800; Eukaryota.
DR GeneTree; ENSGT00940000154585; -.
DR HOGENOM; CLU_026830_1_0_1; -.
DR TreeFam; TF330711; -.
DR Proteomes; UP000002277; Chromosome 5.
DR Bgee; ENSPTRG00000022820; Expressed in temporal lobe and 21 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16465; RING-H2_PJA1_2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15710; E3 UBIQUITIN-PROTEIN LIGASE PRAJA; 1.
DR PANTHER; PTHR15710:SF5; E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 623..664
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 42..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 77035 MW; 9B9DD94414581BAB CRC64;
MDQESGKAVW PKPAGGYQTI TGRRYGRRHA YVSFKPCMTR HERSLGRAGD DYEVLELDDV
PKENSSGSSP LDQVDSSLPS ETIFEKSETE IPTCGSALNQ TTESSQSFVA VHHSEEGRDT
LGSSTNLHNH SEGEYTPGAY NASSVQNGIA LVHTDSYDPD GKHGEDNDCL QLSAEVVEGS
RYQESLGNTV FELENREAEA YTGLSPPVPS FNCEVRDEFE ELDSVPLVKS SAGDTEFVHQ
NSQEIQRSSQ DEMVSTKQQN NTSQERQTEH SPEDAACGPG HICSEQNIND REKNHGSSPE
QVVRPKVRKL ISSSQVDQET GFNRHEAKQR SVQRWREALE VEESGSDDLL IKCEEYDGEH
DCMFLDPPYS RVITQRETEN NQMTSESGAT AGRQEVDNTF WNGCGDYYQL YDKDEDSSEC
SDGEWSASLP HRFSGTEKDQ SSSDESWETL PGKDENEPEL QSDSSGPEEE NQELSLQEGE
QTSLEEGEIP WLQYNEVNES SSDEGNEPAN EFAQPAFMLD GNNNLEDDSS VSEDLDVDWS
LFDGFADGLG VAEAISYVDP QFLTYMALEE RLAQAMETAL AHLESLAVDV EVANPPASKE
SIDGLPETLV LEDHTAIGQE QCCPICCSEY IKDDIATELP CHHFFHKPCV SIWLQKSGTC
PVCRRHFPPA VIEASAAPSS EPDPDAPPSN DSIAEAP
//
