GenomeNet

Database: UniProt
Entry: H2R3J3_PANTR
LinkDB: H2R3J3_PANTR
Original site: H2R3J3_PANTR 
ID   H2R3J3_PANTR            Unreviewed;       977 AA.
AC   H2R3J3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 54.
DE   SubName: Full=Transient receptor potential cation channel, subfamily C, member 4 {ECO:0000313|EMBL:JAA05629.1};
GN   Name=TRPC4 {ECO:0000313|EMBL:JAA05629.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000045620};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000045620, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000045620, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000045620}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|EMBL:JAA05629.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA05629.1}, and Skin
RC   {ECO:0000313|EMBL:JAA28568.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from
RT   NextGen mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACZ03092262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03092263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03092264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03092265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03092266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03092267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03092268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03092269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01005709; JAA05629.1; -; mRNA.
DR   EMBL; GABD01004532; JAA28568.1; -; mRNA.
DR   RefSeq; XP_509635.2; XM_509635.4.
DR   STRING; 9598.ENSPTRP00000045620; -.
DR   Ensembl; ENSPTRT00000049441; ENSPTRP00000045620; ENSPTRG00000005795.
DR   GeneID; 452544; -.
DR   CTD; 7223; -.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   OMA; CILVDHR; -.
DR   OrthoDB; EOG091G029I; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000002277; Chromosome 13.
DR   Bgee; ENSPTRG00000005795; -.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0005901; C:caveola; IEA:Ensembl.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR   GO; GO:0030863; C:cortical cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR   GO; GO:0045296; F:cadherin binding; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0014051; P:gamma-aminobutyric acid secretion; IEA:Ensembl.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005460; TRPC4_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF25; PTHR10117:SF25; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01645; TRPCHANNEL4.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:JAA05629.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    326    350       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    362    381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    401    418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    439    459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    479    498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    519    541       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    561    583       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    595    617       Helical. {ECO:0000256|SAM:Phobius}.
FT   REPEAT      141    173       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   DOMAIN      141    173       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   COILED      227    254       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   977 AA;  112101 MW;  77E4D27C374D660E CRC64;
     MAQFYYKRNV NAPYRDRIPL RIVRAESELS PSEKAYLNAV EKGDYASVKK SLEEAEIYFK
     ININCIDPLG RTALLIAIEN ENLELIELLL SFNVYVGDAL LHAIRKEVVG AVELLLNHKK
     PSGEKQVPPI LLDKQFSEFT PDITPIILAA HTNNYEIIKL LVQKGVSVPR PHEVRCNCVE
     CVSSSDVDSL RHSRSRLNIY KALASPSLIA LSSEDPFLTA FQLSWELQEL SKVENEFKSE
     YEELSRQCKQ FAKDLLDQTR SSRELEIILN YRDDNSLIEE QSGNDLARLK LAIKYRQKEF
     VAQPNCQQLL ASRWYDEFPG WRRRHWAVKM VTCFIIGLLF PVFSVCYLIA PKSPLGLFIR
     KPFIKFICHT ASYLTFLFLL LLASQHIDRS DLNRQGPPPT IVEWMILPWV LGFIWGEIKQ
     MWDGGLQDYI HDWWNLMDFV MNSLYLATIS LKIVAFVKYS ALNPRESWDM WHPTLVAEAL
     FAIANIFSSL RLISLFTANS HLGPLQISLG RMLLDILKFL FIYCLVLLAF ANGLNQLYFY
     YEETKGLTCK GIRCEKQNNA FSTLFETLQS LFWSIFGLIN LYVTNVKAQH EFTEFVGATM
     FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART KLWMSYFEEG GTLPTPFNVI
     PSPKSLWYLI KWIWTHLCKK KMRRKPESFG TIGRRAADNL RRHHQYQEVM RNLVKRYVAA
     MIRDAKTEEG LTEENFKELK QDISSFRFEV LGLLRGSKLS TIQSANASKE SSNSADSDEK
     SDSEGNSKDK KKNFSLFDLT TLIHPRSAAI ASERHNISNG SALVVQEPPR EKQRKVNFVT
     DIKNFGLFHR RSKQNAAEQN ANQIFSVSEE VARQQAAGPL ERNIQLESRG LASRGDLSIP
     GLSEQCVLVD HRERNTDTLG LQVGKRVCPF KSEKVVVEDT VPIIPKEKHA KEEDSSIDYD
     LNLPDTVTHE DYVTTRL
//
DBGET integrated database retrieval system