ID H2R4A7_PANTR Unreviewed; 1207 AA.
AC H2R4A7; A0A2J8KQI7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Calmodulin binding transcription activator 2 {ECO:0000313|Ensembl:ENSPTRP00000046817.5};
GN Name=CAMTA2 {ECO:0000313|Ensembl:ENSPTRP00000046817.5,
GN ECO:0000313|VGNC:VGNC:9163};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000046817.5, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000046817.5, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000046817.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: May interact with calmodulin. {ECO:0000256|ARBA:ARBA00029480}.
CC -!- SIMILARITY: Belongs to the CAMTA family.
CC {ECO:0000256|ARBA:ARBA00008267}.
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DR EMBL; AACZ04040185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016786798.1; XM_016931309.1.
DR AlphaFoldDB; H2R4A7; -.
DR STRING; 9598.ENSPTRP00000067256; -.
DR Ensembl; ENSPTRT00000042902.5; ENSPTRP00000046817.5; ENSPTRG00000023129.5.
DR GeneID; 454458; -.
DR CTD; 23125; -.
DR VGNC; VGNC:9163; CAMTA2.
DR eggNOG; KOG0520; Eukaryota.
DR GeneTree; ENSGT00940000160105; -.
DR HOGENOM; CLU_003170_2_0_1; -.
DR OMA; VQLYSNP; -.
DR OrthoDB; 470813at2759; -.
DR TreeFam; TF323452; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000023129; Expressed in Brodmann (1909) area 10 and 20 other cell types or tissues.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005559; CG-1_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR23335:SF9; CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 2; 1.
DR PANTHER; PTHR23335; CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA; 1.
DR Pfam; PF03859; CG-1; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM01076; CG-1; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR PROSITE; PS51437; CG_1; 1.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 30..160
FT /note="CG-1"
FT /evidence="ECO:0000259|PROSITE:PS51437"
FT REGION 259..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..290
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..482
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1207 AA; 132058 MW; AB9BC9F6FDBAE44F CRC64;
MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY LITFEKHDEW
LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT REDHMKLKVQ GMEPVSWQCL
YGCYVHSSIV PTFHRRCYWL LQNPDIVLVH YLNVPALEDC GKGCSPIFCS ISSDRREWLK
WSREELLGQL KPMFHGIKWS CGNGTEEFSV EHLVQQILDT HPTKAAPRTH ACLCSGGLGS
GSLTHKCSST KHRIISPKVE PRALTLTSIP HPHPPEPPPL IAPLPPELPK AHTSPSSSSS
SSSSGFAEPL EIRPSPPTSR GGSSRGGTAI LLLTGLEQRA GGLTPTRHLA PQADPRPSMS
LAVVVGTEPS APPAPPSPAF DPDRFLNSPQ RGQTYGGGQG VSPDFPEAEA AHTPCSALEP
AAALEPQAAA RGPPPQSVAG GRRGNCFFIQ DDDSGEELKG QGAAPPIPSP PPSPPPSPAP
LEPSSRVGRG EALFGGPVGA SELEPFSLSS FPDLMGELIS DEAPSIPAPT PQLSPALSTI
TDFSPEWSYP EGGVKVLITG PWTEAAEHYS CVFDHIAVPA SLVQPGVLRC YCPAHEVGLV
SLQVAGREGP LSASVLFEYR ARRFLSLPST QLDWLSLDDN QFRMSILERL EQMEKRMAEI
AAAGQVPCQG PDAPAVQDEG QGPGFEARVV VLVESMIPRS TWKGPERLAH GSPFRGMSLL
HLAAAQGYAR LIETLSQWRS VETGSLDLEQ EVDPLNVDHL SCTPLMWACA LGHLEAAVLL
FRWNRQALSI PDSLGRLPLS VAHSRGHVRL ARCLEELQRQ EPSVEPPFAL SPPSSSPDTG
LSSVSSPSEL SDGTFSVTSA YSSAPDGSPP PAPLPASEMT MEDMAPGQLS SGVPEAPLLL
MDYEATNSKG PLSSLPALPP ASDDGAAPED ADSPQAVDVI PVDMISLAKQ IIEATPERIK
REDFVGLPEA GASMRERTGA VGLSETMSWL ASYLENVDHF PSSTPPSELP FERGRLAVPS
APSWAEFLSA STSGKMESDF ALLTLSDHEQ RELYEAARVI QTAFRKYKGR RLKEQQEVAA
AVIQRCYRKY KQLTWIALKF ALYKKMTQAA ILIQSKFRSY YEQKRFQQSR RAAVLIQQHY
RSYRRRPGPP HRTSATLPAR NKGSFLTKKQ DQAARKIMRF LRRCRHRMRE LKQNQELEGL
PQPGLAT
//
