ID H2R5B4_PANTR Unreviewed; 674 AA.
AC H2R5B4; A0A2J8QD19;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Fibronectin leucine rich transmembrane protein 1 {ECO:0000313|Ensembl:ENSPTRP00000048004.2};
GN Name=FLRT1 {ECO:0000313|Ensembl:ENSPTRP00000048004.2,
GN ECO:0000313|VGNC:VGNC:11779};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000048004.2, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000048004.2, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000048004.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004162}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004586}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AC192585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003313089.1; XM_003313041.3.
DR RefSeq; XP_009421605.1; XM_009423330.2.
DR RefSeq; XP_016776620.1; XM_016921131.1.
DR AlphaFoldDB; H2R5B4; -.
DR STRING; 9598.ENSPTRP00000048004; -.
DR PaxDb; 9598-ENSPTRP00000048004; -.
DR Ensembl; ENSPTRT00000055495.3; ENSPTRP00000048004.2; ENSPTRG00000028604.3.
DR GeneID; 742718; -.
DR KEGG; ptr:742718; -.
DR CTD; 23769; -.
DR VGNC; VGNC:11779; FLRT1.
DR eggNOG; ENOG502QWDS; Eukaryota.
DR GeneTree; ENSGT00940000159375; -.
DR HOGENOM; CLU_027624_0_0_1; -.
DR InParanoid; H2R5B4; -.
DR OMA; MTPMAAC; -.
DR OrthoDB; 2916435at2759; -.
DR TreeFam; TF331598; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000028604; Expressed in dorsolateral prefrontal cortex and 13 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF15; LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 553..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 437..532
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 674 AA; 74038 MW; 29E21B75E7F0BCCA CRC64;
MVVAHPTATA TTTPTATVTA TVVMTTATMD LRDWLFLCYG LIAFLTEVID STTCPSVCRC
DNGFIYCNDR GLTSIPADIP DDATTLYLQN NQINNAGIPQ DLKTKVNVQV IYLYENDLDE
FPINLPRSLR ELHLQDNNVR TIARDSLARI PLLEKLHLDD NSVSTVSIEE DAFADSKQLK
LLFLSRNHLS SIPSGLPHTL EELRLDDNRI STIPLHAFKG LNSLRRLVLD GNLLANQRIA
DDTFSRLQNL TELSLVRNSL AAPPLNLPSA HLQKLYLQDN AISHIPYNTL AKMRELERLD
LSNNNLTTLP RGLFDDLGNL AQLLLRNNPW FCGCNLMWLR DWVKARAAVV NVRGLMCQGP
EKVRGMAIKD ITSEMDECFE TGPQGGVANA AAKTTASNHA SATTPQGSLF TLKAKRPGLR
LPDSNIDYPM ATGDGAKTLA IHVKALTADS IRITWKATLP ASSFRLSWLR LGHSPAVGSI
TETLVQGDKT EYLLTALEPK STYIICMVTM ETGNAYVADE TPVCAKAETA DSYGPTTTLN
QEQNAGPMAS LPLAGIIGGA VALVFLFLVL GAICWYVHQA GELLTRERAY NRGSRKKDDY
MESGTKKDNS ILEIHGPGLQ MLPINPYRAK EEYVVHTIFP SNGSSLCKAT HTIGYGTTRG
YRDGGIPDID YSYT
//
