ID H2R695_PANTR Unreviewed; 445 AA.
AC H2R695; A0A2J8N532;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=CASP8 and FADD like apoptosis regulator {ECO:0000313|Ensembl:ENSPTRP00000048882.2};
GN Name=CFLAR {ECO:0000313|Ensembl:ENSPTRP00000048882.2,
GN ECO:0000313|VGNC:VGNC:133};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000048882.2, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000048882.2, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000048882.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134}.
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DR EMBL; AACZ04058664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003949989.1; XM_003949940.3.
DR AlphaFoldDB; H2R695; -.
DR MEROPS; C14.971; -.
DR Ensembl; ENSPTRT00000023719.3; ENSPTRP00000048882.2; ENSPTRG00000012798.6.
DR GeneID; 459872; -.
DR CTD; 8837; -.
DR VGNC; VGNC:133; CFLAR.
DR eggNOG; KOG3573; Eukaryota.
DR GeneTree; ENSGT00530000064199; -.
DR HOGENOM; CLU_036904_4_3_1; -.
DR OrthoDB; 2873736at2759; -.
DR TreeFam; TF352765; -.
DR Proteomes; UP000002277; Chromosome 2B.
DR Bgee; ENSPTRG00000012798; Expressed in lung and 21 other cell types or tissues.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR CDD; cd08337; DED_c-FLIP_r1; 1.
DR CDD; cd08340; DED_c-FLIP_r2; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF4; CASP8 AND FADD LIKE APOPTOSIS REGULATOR; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..73
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 92..170
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 228..323
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
SQ SEQUENCE 445 AA; 51320 MW; 91CD5762D65F6DB2 CRC64;
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT
SYRNVLQAAI QKSLKDPSNN FRSIPEERYK MKSKPLGICL IIDCIGNETE LLRDTFTSLG
YEVQKFLHLS MHGISQILGQ FACMPEHRDY DSFVCVLVSR GGSQSVYGVD QTHSGLPLHH
IRRMFMGDSC PYLAGKPKMF FIQNYVVSEG QLEDSSLLEV DGPAMKNVEF KAQKRGLCTV
HREADFFWSL CTADMSLLEQ SHSSPSLYLQ CLSQKLRQER KRSLLDLHIE LNGYMYDWNS
RVSAKEKYYV WLQHTLRKKL ILSYT
//
