ID H2R699_PANTR Unreviewed; 515 AA.
AC H2R699; A0A2J8NBH2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Solute carrier family 25 member 25 {ECO:0000313|Ensembl:ENSPTRP00000048889.4};
GN Name=SLC25A25 {ECO:0000313|Ensembl:ENSPTRP00000048889.4,
GN ECO:0000313|VGNC:VGNC:8930};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000048889.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000048889.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000048889.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in)
CC + phosphate(out); Xref=Rhea:RHEA:65840, ChEBI:CHEBI:18420,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474;
CC Evidence={ECO:0000256|ARBA:ARBA00034993};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; AC195639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009455622.1; XM_009457347.1.
DR RefSeq; XP_016817233.1; XM_016961744.1.
DR STRING; 9598.ENSPTRP00000048889; -.
DR PaxDb; 9598-ENSPTRP00000048889; -.
DR Ensembl; ENSPTRT00000056209.4; ENSPTRP00000048889.4; ENSPTRG00000021410.7.
DR Ensembl; ENSPTRT00000099236.1; ENSPTRP00000084972.1; ENSPTRG00000043901.1.
DR GeneID; 107976780; -.
DR CTD; 114789; -.
DR VGNC; VGNC:8930; SLC25A25.
DR eggNOG; KOG0036; Eukaryota.
DR GeneTree; ENSGT00940000157207; -.
DR HOGENOM; CLU_015166_2_0_1; -.
DR OMA; VISYAEW; -.
DR OrthoDB; 1330359at2759; -.
DR TreeFam; TF313492; -.
DR Proteomes; UP000002277; Chromosome 9.
DR Bgee; ENSPTRG00000021410; Expressed in liver and 21 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0005347; F:ATP transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0015866; P:ADP transport; IBA:GO_Central.
DR GO; GO:0015867; P:ATP transport; IBA:GO_Central.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002167; GDC-like.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR24089:SF769; CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN SCAMC-2; 1.
DR PANTHER; PTHR24089; SOLUTE CARRIER FAMILY 25; 1.
DR Pfam; PF13499; EF-hand_7; 2.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT DOMAIN 45..80
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 112..147
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REPEAT 230..316
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 324..409
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 421..509
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 515 AA; 56902 MW; 68686811BB622BA2 CRC64;
MVSSVLCRCV ASPPPDAAAT AASSSASSPA SVGDPCGGAI CGGPDHRLRL WRLFQTLDVN
RDGGLCVNDL AVGLRRLGLH RTEGELQKIV QAGDKDLDGQ LDFEEFVHYL QDHEKKLRLV
FKSLDKKNDG RIDAQEIMQS LRDLGVKISE QQAEKILKRI RTGHFWGPVT YMDKNGTMTI
DWNEWRDYHL LHPVENIPEI ILYWKHSTIF DVGENLTVPD EFTVEERQTG MWWRHLVAGG
GAGAVSRTCT APLDRLKVLM QVHASRSNNM GIVGGFTQMI REGGARSLWR GNGINVLKIA
PESAIKFMAY EQIKRLVGSD QETLRIHERL VAGSLAGAIA QSSIYPMEVL KTRMALRKTG
QYSGMLDCAR RILAREGVAA FYKGYVPNML GIIPYAGIDL AVYETLKNAW LQRYAVNSAD
PGVFVLLACG TMSSTCGQLA SYPLALVRTR MQAQASIEGA PEVTMSSLFK HILRTEGAFG
LYRGLAPNFM KVIPAVSISY VVYENLKITL GVQSR
//
