ID H2R6Q9_PANTR Unreviewed; 544 AA.
AC H2R6Q9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=TFIIS N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51319};
GN Name=LOC100609028 {ECO:0000313|Ensembl:ENSPTRP00000049386.4};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000049386.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000049386.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000049386.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00649}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACZ04062510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04065349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016789144.1; XM_016933655.1.
DR AlphaFoldDB; H2R6Q9; -.
DR Ensembl; ENSPTRT00000056626.4; ENSPTRP00000049386.4; ENSPTRG00000041809.2.
DR eggNOG; KOG2821; Eukaryota.
DR GeneTree; ENSGT00390000002428; -.
DR HOGENOM; CLU_021679_0_0_1; -.
DR InParanoid; H2R6Q9; -.
DR OMA; NANTLAH; -.
DR TreeFam; TF317259; -.
DR Proteomes; UP000002277; Chromosome 18.
DR Bgee; ENSPTRG00000041809; Expressed in adult mammalian kidney and 15 other cell types or tissues.
DR GO; GO:0070449; C:elongin complex; IEA:InterPro.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR CDD; cd00183; TFIIS_I; 1.
DR Gene3D; 6.10.250.3180; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR010684; RNA_pol_II_trans_fac_SIII_A.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15141:SF74; TFIIS N-TERMINAL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15141; TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3; 1.
DR Pfam; PF06881; Elongin_A; 1.
DR Pfam; PF08711; Med26; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 5..80
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 80..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..187
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 59578 MW; 3562BB4CA496FC20 CRC64;
MAAGSTTLPA VEKLQVRLAT KTDPKKLEKY LQKLSALPMT ADILAETGIR KTVKRLRKHQ
HVGDFARDLA ARWKKLVLVD RNPGPDPQDP EESASRQRFG EALQDRGKAW GFPENATAPR
SPSHSPEHRR TARTPPGQQR PHPRSPSREP RAERKRPRMA PADSGPHRDP PTRTAPLPMP
EGPEPAVPGE QPGRGHAHAA QGGPLLGQGC QGQPQGEAVG SHSKGHKSSR GASAQKSPPV
QESQSERLQA AGADSAGPKT VPSHVFSELW DPSEAWMQAN YDLLSAFEAM TSQANPEALS
APTLQEEAAF PGRRVNAKMP VYSGSRPACQ LQVPTLRQQC LRVPRNNPDA LGDVEGVPYS
VLEPVLEGWT PDQLYRTEKD NPALARETDE LWRIHCLRDF KEEKPQEHES WRELYLRLRD
AREQRLRVVT TKIRSARENK PSGRQTKMIC FNSVAKTPYD ASRRQEESAG AADPRNGDIE
PAPKPAGSSQ APSGLGDGDG GSISGGSSNQ HAAPADKTRK QAAKKVAPLM AKAIRDYKGR
FSRR
//
