ID H2R734_PANTR Unreviewed; 471 AA.
AC H2R734;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Reticulon 4 receptor {ECO:0000313|Ensembl:ENSPTRP00000049843.3};
GN Name=RTN4R {ECO:0000313|VGNC:VGNC:6015};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000049843.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000049843.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164055; DOI=10.1038/nature02564;
RA Watanabe H., Fujiyama A., Hattori M., Taylor T.D., Toyoda A., Kuroki Y.,
RA Noguchi H., BenKahla A., Lehrach H., Sudbrak R., Kube M., Taenzer S.,
RA Galgoczy P., Platzer M., Scharfe M., Nordsiek G., Bloecker H., Hellmann I.,
RA Khaitovich P., Paabo S., Reinhardt R., Zheng H.-J., Zhang X.-L., Zhu G.-F.,
RA Wang B.-F., Fu G., Ren S.-X., Zhao G.-P., Chen Z., Lee Y.-S., Cheong J.-E.,
RA Choi S.-H., Wu K.-M., Liu T.-T., Hsiao K.-J., Tsai S.-F., Kim C.-G.,
RA Oota S., Kitano T., Kohara Y., Saitou N., Park H.-S., Wang S.-Y.,
RA Yaspo M.-L., Sakaki Y.;
RT "DNA sequence and comparative analysis of chimpanzee chromosome 22.";
RL Nature 429:382-388(2004).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000049843.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000049843.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04061734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2R734; -.
DR Ensembl; ENSPTRT00000026306.4; ENSPTRP00000049843.3; ENSPTRG00000014079.4.
DR VGNC; VGNC:6015; RTN4R.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160711; -.
DR HOGENOM; CLU_000288_18_6_1; -.
DR OMA; HPHAFHD; -.
DR TreeFam; TF330080; -.
DR Proteomes; UP000002277; Chromosome 22.
DR Bgee; ENSPTRG00000014079; Expressed in cerebellar cortex and 14 other cell types or tissues.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF174; RETICULON-4 RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..471
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014160475"
FT DOMAIN 258..308
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 344..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 50659 MW; F3214685A57B251D CRC64;
PARAKRSRLL AWVLWLQAWQ VAAPCPGACV CYNEPKVTTS CPQQGLQAVP VGIPATSQRI
FLHGNRISHV PAASFRACRN LTILWLHSNV LARIDAAAFT GLALLEQLDL SDNAQLRSVD
PATFHGLGRL HTLHLDRCGL QELGPGLFRG LAALQYLYLQ DNALQALPDD TFRDLGNLTH
LFLHGNRISS VPERAFRGLH SLDRLLLHQN RVAHVHPHAF RDLGRLMTLY LFANNLSALP
TEALAPLRAL QYLRLNDNPW VCDCRARPLW AWLQKFRGSS SEVPCSLPQR LAGRDLKRLA
ANDLQGCAVA TGPYHPIWTG RATDEEPLGL PKCCQPDAAD KASVLEPGRP ASAGNALKGR
VPPGDSPPGN GSGPRHINDS PFGTLPGSAE PPLTAVRPEG SEPPGFPTSG PRRRPGCSRK
NRTRSHCRLG QAGSGGGGTG DSEGSGALPS LTCSLTPLGL ALVLWTVLGP C
//
