ID H2R749_PANTR Unreviewed; 797 AA.
AC H2R749;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Interphotoreceptor matrix proteoglycan 1 {ECO:0000256|ARBA:ARBA00040753};
DE AltName: Full=Sialoprotein associated with cones and rods {ECO:0000256|ARBA:ARBA00042018};
GN Name=IMPG1 {ECO:0000313|Ensembl:ENSPTRP00000049902.3,
GN ECO:0000313|VGNC:VGNC:3126};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000049902.3, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000049902.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000049902.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer
CC segment {ECO:0000256|ARBA:ARBA00004504}. Photoreceptor inner segment
CC {ECO:0000256|ARBA:ARBA00004437}. Secreted, extracellular space,
CC extracellular matrix, interphotoreceptor matrix
CC {ECO:0000256|ARBA:ARBA00004593}.
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DR EMBL; AACZ04027202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04027203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04027204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2R749; -.
DR PaxDb; 9598-ENSPTRP00000049902; -.
DR Ensembl; ENSPTRT00000057065.3; ENSPTRP00000049902.3; ENSPTRG00000018360.7.
DR VGNC; VGNC:3126; IMPG1.
DR eggNOG; ENOG502QTXX; Eukaryota.
DR GeneTree; ENSGT00530000063503; -.
DR HOGENOM; CLU_005111_1_0_1; -.
DR OMA; SECVMNE; -.
DR TreeFam; TF331340; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000018360; Expressed in pituitary gland and 7 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0033165; C:interphotoreceptor matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR GO; GO:0001750; C:photoreceptor outer segment; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR Gene3D; 3.30.70.960; SEA domain; 2.
DR InterPro; IPR039861; IMPG.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR12199; INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN; 1.
DR PANTHER; PTHR12199:SF3; INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN 1; 1.
DR Pfam; PF01390; SEA; 2.
DR SMART; SM00200; SEA; 2.
DR SUPFAM; SSF82671; SEA domain; 2.
DR PROSITE; PS50024; SEA; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022981};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Hyaluronic acid {ECO:0000256|ARBA:ARBA00023290};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Sialic acid {ECO:0000256|ARBA:ARBA00022981};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..797
FT /note="Interphotoreceptor matrix proteoglycan 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030172271"
FT DOMAIN 232..354
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 571..684
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
SQ SEQUENCE 797 AA; 89366 MW; D44E67BDF569C136 CRC64;
MYLETRRAIF VFWIFLQVQG TKDISINIYH SETKDIDNPP RNETTESTEK MYKISTMRRI
FDLAKHRTKR SAFFPTGVKV CPQESMKQIL ASLQAYYRLR VCQEAVWEAY RIFLDRIPDT
GEYQDWVSIC QQETFCLFDI GKNFSNSQEH LDLLQQRIKQ RSFPDRKDEI STEKTLGEPG
ETIVTSTDVA SVSLGPFPLT PDDTLLNEIL DNTLNDTKMP TTERETEFAV LEEQRVELSV
SLVNQRFKAE LADSQSPYYQ ELAGKSQLQM QKIFKKLPGF KKIHVLGFRP KKEKDGSSST
EMQLTAIFKR HSAEAKSPAS DLLSFDSNKI ESEEVYHGTM EEDKQPEIYL TATDLKRLIS
KALEEEQSLD VGTIQFADEI AGSLPAFGPD TQSELPTSFA VITEDATLSP ELPLVEPQLE
TVDGAEHGLP DTSWSPPAMA STSLSEALPF FTASSIFSLT DQGTTDTMAT DQTMLVPGLT
IPTSDYSAIS QLALGISHPP ASSDDSRSSA GGEDMVRDLD EMDLSDTPAP SEVPELSEYV
SVPDHFLEDT TPVSALQYIT TSSMTIAPKG RELVVFFSLR VANMAFSNDL FNKSSLEYRA
LEQQFTQLLV PYLRSNLTGF KQLEILNFRN GSVIVNSKMK FAKSVPYNLT KAVHGVLEDF
RSAAAQQLHL EIDSYSLNIE PADQADPCKF LACGEFAQCV KNEWTEEAEC HCKPGYDSQG
GLDGLEPGLC VPGTKECEVL QGKGASCRLR DHSENQAYKT SVKKFQNQQN NKVISKRNSE
LLTVEYEEFN HQDWEGN
//
