ID H2R7S2_PANTR Unreviewed; 691 AA.
AC H2R7S2; A0A2J8K652;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Zinc transporter ZIP12 {ECO:0000256|ARBA:ARBA00040591};
DE AltName: Full=Solute carrier family 39 member 12 {ECO:0000256|ARBA:ARBA00042541};
DE AltName: Full=Zrt- and Irt-like protein 12 {ECO:0000256|ARBA:ARBA00042971};
GN Name=SLC39A12 {ECO:0000313|Ensembl:ENSPTRP00000050752.4,
GN ECO:0000313|VGNC:VGNC:8885};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000050752.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000050752.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000050752.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; AACZ04053992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04053993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04053994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04053995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001153573.2; XM_001153573.3.
DR AlphaFoldDB; H2R7S2; -.
DR STRING; 9598.ENSPTRP00000050752; -.
DR PaxDb; 9598-ENSPTRP00000050752; -.
DR Ensembl; ENSPTRT00000057815.4; ENSPTRP00000050752.4; ENSPTRG00000002338.6.
DR GeneID; 739440; -.
DR CTD; 221074; -.
DR VGNC; VGNC:8885; SLC39A12.
DR eggNOG; KOG2693; Eukaryota.
DR GeneTree; ENSGT00940000157914; -.
DR HOGENOM; CLU_015114_12_1_1; -.
DR InParanoid; H2R7S2; -.
DR OMA; AQVCFSA; -.
DR OrthoDB; 5488029at2759; -.
DR TreeFam; TF318470; -.
DR Proteomes; UP000002277; Chromosome 10.
DR Bgee; ENSPTRG00000002338; Expressed in dorsolateral prefrontal cortex and 11 other cell types or tissues.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0140410; F:monoatomic cation:bicarbonate symporter activity; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0031113; P:regulation of microtubule polymerization; IEA:Ensembl.
DR GO; GO:0010975; P:regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR GO; GO:0071578; P:zinc ion import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR049406; ZIP4_12_EF-hand.
DR InterPro; IPR041137; ZIP4_N.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF4; ZINC TRANSPORTER ZIP12; 1.
DR Pfam; PF21116; EF-hand_Zip; 1.
DR Pfam; PF02535; Zip; 1.
DR Pfam; PF18292; ZIP4_domain; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022906};
KW Zinc {ECO:0000256|ARBA:ARBA00022906};
KW Zinc transport {ECO:0000256|ARBA:ARBA00022906}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..691
FT /note="Zinc transporter ZIP12"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015093374"
FT TRANSMEM 367..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..222
FT /note="Zinc transporter ZIP4 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18292"
FT DOMAIN 230..346
FT /note="Zinc transporter ZIP4/12 EF-hand"
FT /evidence="ECO:0000259|Pfam:PF21116"
SQ SEQUENCE 691 AA; 76651 MW; B821E90A5301960F CRC64;
MCFRTKLSVS WVPLFLLLSR VFSTETDKPS AQDSRGRGSS GQLADLLQVL SAGDHPPHNH
SRSLIKTLLE KTGCPRRRNG MRGDCNLCFE PDALLLIAGG NFEDQLREEV VQRVSLLLLY
YIIHQEEICS SKLNMSNKEY KFYLHSLLSL RQDEDSSFLS QNETEDILAF TRQYFDTSQS
QCMETKTLQK KSGIVSSEGA NESTLPQLAA MIITLSLQGV CLGQGNLPSP DYFTEYIFSS
LNRTNTLRLS ELDQLLNTLW TRSTCIKNEK IHQFQRKQNN IITRDQDYSN FSSSMEKESE
DGPVSWDQTC FSARQLVEIF LQKGLSLISK EDFKQMSPGI IQQLLSCSCH LPKDQQAKLP
PTTLEKYGYS TVAVTLLTLG SMLGTALVLF HSCEENYRLI LQLFVGLAVG TLSGDALLHL
IPQVLGLHKQ EAPEFGHFHE SKGHIWKLLG LIGGIHGFFL IEKCFILLVS PNDKQGLSLV
NGHVGHSHHL ALNSELSDQA GRGKSASTIQ LKSPEDSQAA EMPIGSMTAS NRKCKAISLL
AIMILVGDGL HNFADGLAIG AAFSSSSESG VTTTIAILCH EIPHEMGDFA VLLSSGLSMK
TAILMNFISS LTAFMGLYIG LSVSADPCVQ DWIFTVTAGM FLYLSLVEML PEMTHVQTQR
PWMMFLLQNF GLILGWLSLL LLAIYEQNIK I
//
