ID   H2R8F0_PANTR            Unreviewed;       278 AA.
AC   H2R8F0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=N-terminal Xaa-Pro-Lys N-methyltransferase 2 {ECO:0000313|Ensembl:ENSPTRP00000051541.3};
GN   Name=NTMT2 {ECO:0000313|Ensembl:ENSPTRP00000051541.3,
GN   ECO:0000313|VGNC:VGNC:10716};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000051541.3, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000051541.3, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000051541.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. NTM1 family.
CC       {ECO:0000256|ARBA:ARBA00009059}.
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DR   EMBL; AACZ04056267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H2R8F0; -.
DR   PaxDb; 9598-ENSPTRP00000051541; -.
DR   Ensembl; ENSPTRT00000058530.3; ENSPTRP00000051541.3; ENSPTRG00000030294.3.
DR   VGNC; VGNC:10716; NTMT2.
DR   eggNOG; KOG3178; Eukaryota.
DR   GeneTree; ENSGT00390000008371; -.
DR   HOGENOM; CLU_055356_3_0_1; -.
DR   InParanoid; H2R8F0; -.
DR   OMA; QWVSGNL; -.
DR   TreeFam; TF314174; -.
DR   Proteomes; UP000002277; Chromosome 1.
DR   Bgee; ENSPTRG00000030294; Expressed in heart and 5 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0071885; F:N-terminal protein N-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR008576; MeTrfase_NTM1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR12753; AD-003 - RELATED; 1.
DR   PANTHER; PTHR12753:SF2; N-TERMINAL XAA-PRO-LYS N-METHYLTRANSFERASE 2; 1.
DR   Pfam; PF05891; Methyltransf_PK; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ   SEQUENCE   278 AA;  31995 MW;  684B262F9EB73E2D CRC64;
     MAHLGAHFAF RSRWQKTDDE LCRHSMSFIL HKAIRNDFFQ SYLYLLEKIP LVKLYALTSQ
     VINGEMQFYA RAKLFYQEVP ATEEGMMGNF IELSSPDIQA SQKFLRKFVG VSYSTADCGS
     GIGRVSKHVL LPVFNSVELV DMMESFLLEA QNYLQVKGDK VESYHCYSLQ EFTPPFRRYD
     VIWIQWVSGH LTDKDLLAFL SRCRDGLKEN GIIILKDNVA REGCILDLSD SSVTRDMDIL
     RSLIRKSGLV VLGQEKQDGF PEQCIPVWMF VLHSDRHS
//