ID H2R921_PANTR Unreviewed; 344 AA.
AC H2R921;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Integrin subunit alpha L {ECO:0000313|Ensembl:ENSPTRP00000052270.4};
GN Name=ITGAL {ECO:0000313|VGNC:VGNC:13720};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000052270.4, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000052270.4, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000052270.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04059904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2R921; -.
DR PaxDb; 9598-ENSPTRP00000052270; -.
DR Ensembl; ENSPTRT00000059160.4; ENSPTRP00000052270.4; ENSPTRG00000008004.6.
DR VGNC; VGNC:13720; ITGAL.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000161495; -.
DR HOGENOM; CLU_004111_3_0_1; -.
DR InParanoid; H2R921; -.
DR OMA; IFRCNIS; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000002277; Chromosome 16.
DR Bgee; ENSPTRG00000008004; Expressed in lymph node and 18 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.2120; -; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF84; INTEGRIN ALPHA-L; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 264..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 302..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 344 AA; 37928 MW; 12A7B22932B93EB2 CRC64;
MKDSCITVMA MALLSGFFFF APASSYNLDV RGARSFSPPR AGRHFGYRVL QMMFNTLVNS
SWGDSVELRA NVTCNNEDSD LLEDNSATTI IPILYPINIL IQDQENSTLY VSFTPKGPKI
HQVKHMYQVR IQPSIHDHNI PTLEAVVGVP QPPSQGPITH QWSVQMEPPV PCHYEDLERL
PDAAEPCLPG ALLRCPVVFR QEILVQVIGT LELVGEIEAS SMFSLCSSLS ISFNSSKHFH
LYGSNASLAQ VVMKVDVVYE KQMLYLYVLS GIGGLLLLLL IFIVLYKVGF FKRNLKEKME
AGRGVPNGIP AEDSEQLASG QEAGDPGCLK PLHEKDSESG GGKD
//
