UniProt: H2RA41

Database: UniProt
Entry: H2RA41_PANTR

LinkDB:  H2RA41_PANTR 
Original site:  H2RA41_PANTR

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (4)   
   InterPro (2)   
   Pfam (1)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (16)   

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ID   H2RA41_PANTR            Unreviewed;       527 AA.
AC   H2RA41; A0A2J8PF14;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE            EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN   Name=UGT2A3 {ECO:0000313|Ensembl:ENSPTRP00000053491.2,
GN   ECO:0000313|VGNC:VGNC:50364};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000053491.2, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000053491.2, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000053491.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC         Evidence={ECO:0000256|RuleBase:RU362059};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; Single-
CC       pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR   EMBL; AACZ04033903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_526602.2; XM_526602.3.
DR   AlphaFoldDB; H2RA41; -.
DR   STRING; 9598.ENSPTRP00000053491; -.
DR   PaxDb; 9598-ENSPTRP00000053491; -.
DR   Ensembl; ENSPTRT00000045935.4; ENSPTRP00000053491.2; ENSPTRG00000022603.4.
DR   GeneID; 471220; -.
DR   CTD; 79799; -.
DR   VGNC; VGNC:50364; UGT2A3.
DR   eggNOG; KOG1192; Eukaryota.
DR   GeneTree; ENSGT00940000162432; -.
DR   HOGENOM; CLU_012949_3_0_1; -.
DR   InParanoid; H2RA41; -.
DR   OMA; QLFCVGC; -.
DR   OrthoDB; 382054at2759; -.
DR   TreeFam; TF315472; -.
DR   Proteomes; UP000002277; Chromosome 4.
DR   Bgee; ENSPTRG00000022603; Expressed in adult mammalian kidney and 2 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0052695; P:cellular glucuronidation; IBA:GO_Central.
DR   GO; GO:0008210; P:estrogen metabolic process; IBA:GO_Central.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48043:SF47; UDP-GLUCURONOSYLTRANSFERASE 2A3; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU003718};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Signal {ECO:0000256|RuleBase:RU362059};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362059};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362059}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT   CHAIN           24..527
FT                   /note="UDP-glucuronosyltransferase"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT                   /id="PRO_5015019832"
FT   TRANSMEM        491..512
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
SQ   SEQUENCE   527 AA;  60276 MW;  F7F8326B07EF678B CRC64;
     MRSDKSALVF LLLQLFCVGC GFCGKVLVWP CDMSHWLNVK VILEELIVRG HEVTVLTHSK
     SLLIDYRKSS ALKFEVVHLP QDRTEENEIF VDLALNVLPG LPTWQSVIKL NDFFVEIRGT
     LKMMCESFIY NQTLMKKLQE TNYDVMLIDP VIPCGDLMAE LLAVPFVLTL RISVGGNMER
     SCGKLPAPLS YVPVPMTGLT DRMTFLERVK NSLLSVLFYF WIQDYDYHFW EEFYSKALGR
     PTTLCETVGK AEIWLIRTYW DFEFPQPYQP NFEFVGGLHC KPAKALPKEM ENFVQSSGED
     GIVVFSLGSI FQNVTEEKAN IIASALAQIP QKVLWRYKGK KPSTLGANTR LYDWIPQNDL
     LGHPKTKAFI THGGMNGIYE AIYHGVPMVG VPIYGDQLDN IAHMKAKGAA VEINFKTMTS
     EDLLRALRTV ITDSSYKENA MRLSRIHHDQ PVKPLDRAVF WIEFVMRHKG AKHLRSAAHD
     LTWFQHYSID VIGFLLACVA TAIFLFTKCF LFSCQKFNKT RKIEKRE
//

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