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Database: UniProt
Entry: H2RCB4_PANTR
LinkDB: H2RCB4_PANTR
Original site: H2RCB4_PANTR 
ID   H2RCB4_PANTR            Unreviewed;      4858 AA.
AC   H2RCB4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   07-JUN-2017, entry version 37.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPTRP00000057052};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSPTRP00000057052};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000057052, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000057052, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136134; DOI=10.1038/nature04101;
RA   Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
RA   Rozen S., Wilson R.K., Page D.C.;
RT   "Conservation of Y-linked genes during human evolution revealed by
RT   comparative sequencing in chimpanzee.";
RL   Nature 437:100-103(2005).
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000057052}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000057052}.
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DR   EMBL; AACZ03101331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03101332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03101333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03101334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03101335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03101336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03101337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03101338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03101339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AACZ03101340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000057052; -.
DR   PaxDb; H2RCB4; -.
DR   Ensembl; ENSPTRT00000065488; ENSPTRP00000057052; ENSPTRG00000006872.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H2RCB4; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000002277; Chromosome 15.
DR   Bgee; ENSPTRG00000006872; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 9.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4171   4195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4399   4419       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4467   4486       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4598   4616       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4659   4680       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4739   4762       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1455       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3907   3942       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4321   4348       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4858 AA;  550922 MW;  5FA9D452450C9E8E CRC64;
     MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP
     PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAVL LRHSFSGMYL
     TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSVSNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD
     QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
     QGLILQDRAK SDTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS
     GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ
     FVSGNNRTAA PITLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNIYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN
     NLDWLISKLD RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI
     LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW
     YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGRIPRAVAS INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS
     FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGIRDLLGT
     TQFLSQASFI PCPVDTSQVV LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR
     QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS
     NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
     PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD SAVEKVSIDK IRFFRVERSY
     AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DVELGADDQA FVFEGNRGQR WHQGSGYFGR
     TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR
     MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVMRID
     GTMDSPPCLK VTHKTFGTQN SNADMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI
     LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSDKFD LNKNGRVHES VKRSNCYMVW
     GGDIVASSQR SNRSNVDLEI GCLVDLAMGM LSFSANGKEL GTCYQVEPNT KVFPAVFLQP
     TSTSLFQFEL GKLKNAMPLS AAIFRSEEKN PVPQCPPRLD VQTIQPVLWS RMPNSFLKVE
     TERVSERHGW VVQCLEPLQM MALHIPEENR CVDILELCEQ EDLMRFHYHT LRLYSAVCAL
     GNSRVAYALC SHVDLSQLFY AIDNKYLPGL LRSGFYDLLI SIHLANAKER KLMMKNEYII
     PITSTTRNIR LFPDESKRHG LPGVGLRTCL KPGFRFSTPC FVVTGEDHQK QSPEIPLESL
     RTKALSMLTE AVQCSGAHIR DPVGGSVEFQ FVPVLKLIGT LLVMGVFDDD DVWQILLLID
     PSVFGEHSAG TEEGAEKEEV TQVEEKAVEA GEKAGKEAPV KGLLQTRLPE SVKLQMCELL
     SYLCDCELQH RVEAIVAFGD IYVSKLQANQ KFRYNELMQA LNMSAALTAR KTKEFRSPPQ
     EQINMLLNFQ LGENCPCPEE IREELYDFHE DLLLHCGVPL EEEEEEEEDT SWTGKLCALV
     YKIKGPPKPE KEQPTEEEER CPTTLKELIS QTMICWAQED QIQDSELVRM MFNLLRRQYD
     SIGELLQALR KTYTISHTSV SDTINLLAAL GQIRSLLSVR MGKEEELLMI NGLGDIMNNK
     VFYQHPNLMR VLGMHETVME VMVNVLGTEK SQIAFPKMVA SCCRFLCYFC RISRQNQKAM
     FEHLSYLLEN SSVGLASPSM RGSTPLDVAA SSVMDNNELA LSLEEPDLEK VVTYLAGCGL
     QSCPMLLAKG YPDVGWNPIE GERYLSFLRF AVFVNSESVE ENASVVVKLL IRRPECFGPA
     LRGEGGNGLL AAMQGAIKIS ENPALDLPSQ GYKREVSTED DEEEEEIVHM GNAIMTFYSA
     LIDLLGRCAP EMHLIQTGKG EAIRIRSILR SLVPTEDLVG IISIPLKLPS LNKDGSVSEP
     DMAANFCPDH KAPMVLFLDR VYGIKDQTFL LHLLEVGFLP DLRASASLDT VSLSTTEAAL
     ALNRYICSAV LPLLTRCAPL FAGTEHCTSL IDSTLQTIYR LSKGRSLTKA QRDTIEECLL
     AICNHLRPSM LQQLLRRLVF DVPQLNEYCK MPLKLLTNHY EQCWKYYCLP SGWGSYGLAV
     EEELHLTEKI FWGIFDSLSH KKYDPDLFRM ALPCLSAIAG ALPPDYLDTR ITATLEKQIS
     VDADGNFDPK PINTMNFSLP EKLEYIVTKY AEHSHDKWAC DKSQSGWKYG ISLDENVKTH
     PLIRPFKTRE KEKEIYRWPA RESLKTMLAV GWTVERTKEG EALVQQRENE KLRSVSQANQ
     GNSYSPAPLD LSNVVLSREL QGMVEVVAEN YHNIWAKKKK LELESKGGGS HPLLVPYDTL
     TAKEKFKDRE KAQDLFKFLQ VNGIIVSRGM KDMELDASSM EKRFAYKFLK KILKYVDSAQ
     EFIAHLEAIV SSGKTEKSPH DQEIKFFAKV LLPLVDQYFT NHCLYFLSSP LKPLSSSGYA
     SHKEKEMVAS LFCKLAALVR HRISLFGSDS TTMVSCLHIL AQTLDTRTVM KSGSELVKAG
     LRAFFENAAE DLEKTSENLK LGKFTHSRTQ IKGVSQNINY TTVALLPILT SIFEHVTQHQ
     FGMDLLLGDV QISCYHILCS LYSLGTGKNI YVERQRPALG ECLASLAAAI PVAFLEPTLN
     RYNPLSVFNT KTPRERSILG MPDTVEDMCP DIPQLEGLMK EINDLAESGA RYTEMPHVIE
     VILPMLCNYL SYWWERGPEN LPPSTGPCCT KVTSEHLSLI LGNILKIINN NLGIDEASWM
     KRIAVYAQPI ISKARPDLLR SHFIPTLEKL KKKAVKTVQE EEQLKADGKG DTQEAELLIL
     DEFAVLCRDL YAFYPMLIRY VDNNRSNWLK SPDADSDQLF RMVAEVFILW CKSHNFKREE
     QNFVIQNEIN NLAFLTGDSK SKMSKAMQVK SGGQDQERKK TKRRGDLYSI QTSLIVAALK
     KMLPIGLNMC TPGDQELISL AKSRYSHRDT DEEVREHLRN NLHLQEKSDD PAVKWQLNLY
     KNVLKSEEPF NPEKTVERVQ RISAAVFHLE QVEQPLRSKK AVWHKLLSKQ RKRAVVACFR
     MAPLYNLPRH RSINLFLHGY QRFWIETEEY SFEEKLVQDL AKSPKVEEEE EEETEKQPDP
     LHQIILYFSR NALTERSKLE DDPLYTSYSS MMAKSCQSGE DEEEDEDKEK TFEEKEMEKQ
     KTLYQQARLH ERGAAEMVLQ MISASKGEMS PMVVETLKLG IAILNGGNAG VQQKMLDYLK
     EKKDAGFFQS LSGLMQSCSV LDLNAFERQN KAEGLGMVTE EGTLIVRERG EKVLQNDEFT
     CDLFRFLQLL CEGHNSDFQN FLRTQMGNTT TVNVIISTVD YLLRLQESIS DFYWYYSGKD
     IIDESGQHNF SKALAVTKQI FNSLTEYIQG PCIGNQQSLA HSRLWDAVVG FLHVFANMQM
     KLSQDSSQIE LLKELLDLLQ DMVVMLLSLL EGNVVNGTIG KQMVDTLVES STNVEMILKF
     FDMFLKLKDL TSSDTFKEYD PDGKGIISKK EFQKAMEGQK QYTQSEIDFL LSCAEADEND
     MFNYVDFVDR FHEPAKDIGF NVAVLLTNLS EHMPNDSRLK CLLDPAESVL NYFEPYLGRI
     EIMGGAKKIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGEQEKM ELFVNFCEDT
     IFEMQLASQI SESDSADRPE EEEEDEDSSY VLEIAGEEEE DGSLEPASAF AMACASVKRN
     VTDFLKRATL KNLRKQYRNV KKMTAKELVK VLFSFFWMLF VGLFQLLFTI LGGIFQILWS
     TVFGGGLVEG AKNIRVTKIL GDMPDPTQFG IHDDTMEAER AEVMEPGITT ELVHFIKGEK
     GDTDIMSDLF GLHPKKEGSL KHGPEVGLGD LSEIIGKDEP PTLESTVQKK RKAQAAEMKA
     ANEAEGKVES EKADMEDGEK EDKDKEEEQA EYLWTEVTKK KKRRCGQKVE KPEAFTANFF
     KGLEIYQTKL LHYLARNFYN LRFLALFVAF AINFILLFYK VTEEPLEEET EDVANLWNSF
     NDEEEEEAMV FFVLQESTGY MAPTLRALAI IHTIISLVCV VGYYCLKVPL VVFKREKEIA
     RKLEFDGLYI TEQPSEDDIK GQWDRLVINT PSFPNNYWDK FVKRKVINKY GDLYGAERIA
     ELLGLDKNAL DFSPVEETKA EAASLVSWLS SIDMKYHIWK LGVVFTDNSF LYLAWYTTMS
     VLGHYNNFFF AAHLLDIAMG FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF
     RKFYNKSEDD DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD EIEDPAGDPY EMYRIVFDIT
     FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VREDMETKCF ICGIGNDYFD TTPHGFETHT
     LQEHNLANYL FFLMYLINKD ETEHTGQESY VWKMYQERCW DFFPAGDCFR KQYEDQLG
//
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