ID H2RE49_PANTR Unreviewed; 381 AA.
AC H2RE49; A0A2J8KUE8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Transcription elongation factor A N-terminal and central domain containing {ECO:0000313|Ensembl:ENSPTRP00000059784.2};
GN Name=TCEANC {ECO:0000313|VGNC:VGNC:11623};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000059784.2, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000059784.2, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000059784.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
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DR EMBL; AACZ04014634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2RE49; -.
DR STRING; 9598.ENSPTRP00000059784; -.
DR PaxDb; 9598-ENSPTRP00000059784; -.
DR Ensembl; ENSPTRT00000074907.2; ENSPTRP00000059784.2; ENSPTRG00000038795.2.
DR VGNC; VGNC:11623; TCEANC.
DR eggNOG; KOG1105; Eukaryota.
DR GeneTree; ENSGT00940000162067; -.
DR HOGENOM; CLU_890113_0_0_1; -.
DR InParanoid; H2RE49; -.
DR OMA; FNCKVTV; -.
DR TreeFam; TF314970; -.
DR Proteomes; UP000002277; Chromosome X.
DR Bgee; ENSPTRG00000038795; Expressed in bone marrow and 19 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006351; P:DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 2.20.25.10; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR Gene3D; 1.10.472.30; Transcription elongation factor S-II, central domain; 1.
DR InterPro; IPR035100; TF_IIS-typ.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR11477:SF7; TRANSCRIPTION ELONGATION FACTOR A N-TERMINAL AND CENTRAL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11477; TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08711; Med26; 1.
DR Pfam; PF07500; TFIIS_M; 1.
DR PIRSF; PIRSF006704; TF_IIS; 1.
DR SMART; SM00510; TFS2M; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR SUPFAM; SSF46942; Elongation factor TFIIS domain 2; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 35..112
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT DOMAIN 203..319
FT /note="TFIIS central"
FT /evidence="ECO:0000259|PROSITE:PS51321"
FT REGION 116..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 381 AA; 43200 MW; 6C5FB582E3305508 CRC64;
MISAHRKLCL PGSSNSPASA FRVAGTTAVK MSDKNQIAAR ASLIEQLMSK RNFEDLGNHL
TELETIYVTK EHLQETDVVR AVYRVLKNCP SVALKKKAKC LLSKWKAVYK QTHSKARNSP
KLFPVRDNKE ENSGPSHDPS QNETLGICSS NSLSSQDVAK LSEMIVPENR ATQLKPKEEH
FGDGDPESTG KRSSELLDPT TPMRTKCIEL LYAALTSSST DQPKAGLWQN FAREIEEHVF
TLYSKNIKKY KTCIRSKVAN LKNPRNSHLQ QNLLSGTTSP REFAEMTVME MANKELKQLR
ASYTESCIQE HYLPQVIDGT QTNKIKCRRC EKYNCKVTVI DRGTLFLPSW VRNSNPDEQM
MTYVICNECG EQWYHSKWVC L
//
