ID H2REL0_PANTR Unreviewed; 318 AA.
AC H2REL0; A0A2J8QUK6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047};
GN Name=OR2A2 {ECO:0000313|Ensembl:ENSPTRP00000059948.1,
GN ECO:0000313|VGNC:VGNC:8711};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000059948.1, ECO:0000313|Proteomes:UP000002277};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000059948.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|Ensembl:ENSPTRP00000059948.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Odorant receptor. {ECO:0000256|ARBA:ARBA00002936}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AC187527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016813829.1; XM_016958340.1.
DR AlphaFoldDB; H2REL0; -.
DR STRING; 9598.ENSPTRP00000059948; -.
DR PaxDb; 9598-ENSPTRP00000059948; -.
DR Ensembl; ENSPTRT00000074309.2; ENSPTRP00000059948.1; ENSPTRG00000049604.1.
DR GeneID; 744419; -.
DR KEGG; ptr:744419; -.
DR CTD; 442361; -.
DR VGNC; VGNC:8711; OR2A2.
DR eggNOG; ENOG502T1JY; Eukaryota.
DR GeneTree; ENSGT00940000153255; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; H2REL0; -.
DR OMA; LMNQKRT; -.
DR OrthoDB; 5259681at2759; -.
DR TreeFam; TF337251; -.
DR Proteomes; UP000002277; Chromosome 7.
DR Bgee; ENSPTRG00000049604; Expressed in colon.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR CDD; cd15420; 7tmA_OR2A-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR26453:SF82; OLFACTORY RECEPTOR-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU363047};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363047};
KW Olfaction {ECO:0000256|ARBA:ARBA00022725, ECO:0000256|RuleBase:RU363047};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Sensory transduction {ECO:0000256|RuleBase:RU363047};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363047}.
FT TRANSMEM 21..48
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 93..116
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 136..161
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 198..224
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 236..260
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT DOMAIN 40..289
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 318 AA; 35730 MW; 6361ABC0E1D07358 CRC64;
MEGNQTWITD ITLLGFQVGP ALAILLCGLF SVFYTLTLLG NGVIFGIICL DSKLHTPMYF
FLSHLAIIDM SYASNNVPKM LANLMNQKRT ISFVPCIMQT FLYLAFAVTE CLILVVMSYD
RYVAICHPLQ YTVIMSWRVC TILAVMSWSC GFALSLVHAI LLLRLPFCGP RDVNHLFCEI
LSILKLACAD TWVNQVVIFA TCVFVLVGPL SLILVSYMHI LGAILKIQTK EGRIKAFSTC
SSHLCVVGLF FGIAMVVYMV PDSNQREEQE KMLSLFHSVF NPMLNPLIYS LRNAQLKGAL
HRALQRKRSM RTVYGLCL
//
