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Database: UniProt
Entry: H2RII6_PANTR
LinkDB: H2RII6_PANTR
Original site: H2RII6_PANTR 
ID   H2RII6_PANTR            Unreviewed;       536 AA.
AC   H2RII6; A0A2J8LL94;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 90.
DE   SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:JAA10452.1, ECO:0000313|Ensembl:ENSPTRP00000061344.1};
GN   Name=SOCS5 {ECO:0000313|EMBL:JAA10452.1,
GN   ECO:0000313|Ensembl:ENSPTRP00000061344.1,
GN   ECO:0000313|VGNC:VGNC:10771};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000061344.1, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000061344.1, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|EMBL:JAA10452.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA10452.1}, Skeletal muscle
RC   {ECO:0000313|EMBL:JAA34565.1}, Skin {ECO:0000313|EMBL:JAA30736.1}, and
RC   Smooth vascular {ECO:0000313|EMBL:JAA16294.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT   mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPTRP00000061344.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   EMBL; AACZ04001940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01000886; JAA10452.1; -; mRNA.
DR   EMBL; GABC01000885; JAA10453.1; -; mRNA.
DR   EMBL; GABF01005851; JAA16294.1; -; mRNA.
DR   EMBL; GABD01002364; JAA30736.1; -; mRNA.
DR   EMBL; GABD01002363; JAA30737.1; -; mRNA.
DR   EMBL; GABE01010174; JAA34565.1; -; mRNA.
DR   RefSeq; XP_016803969.1; XM_016948480.1.
DR   RefSeq; XP_016803970.1; XM_016948481.1.
DR   SMR; H2RII6; -.
DR   STRING; 9598.ENSPTRP00000061344; -.
DR   PaxDb; 9598-ENSPTRP00000061344; -.
DR   Ensembl; ENSPTRT00000075627.2; ENSPTRP00000061344.1; ENSPTRG00000040283.2.
DR   GeneID; 459209; -.
DR   KEGG; ptr:459209; -.
DR   CTD; 9655; -.
DR   VGNC; VGNC:10771; SOCS5.
DR   eggNOG; KOG4566; Eukaryota.
DR   GeneTree; ENSGT00940000159000; -.
DR   HOGENOM; CLU_035609_1_0_1; -.
DR   OMA; CQNLFNH; -.
DR   OrthoDB; 5362214at2759; -.
DR   TreeFam; TF321368; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000002277; Chromosome 2A.
DR   Bgee; ENSPTRG00000040283; Expressed in fibroblast and 21 other cell types or tissues.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR   CDD; cd03739; SOCS_SOCS5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR037343; SOCS5_SOCS.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          381..476
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          471..520
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          115..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..160
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  61246 MW;  0629CDCF2A97E9D8 CRC64;
     MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV KEKNISIGDS TPQQQSSPLR
     ENIALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDNDS CVTPGTRLAR RDSYSRHAPW
     GGKKKHSCST KTQSSLDADK KFGRTRSGLQ RRERRYGVSS VHDMDSVSSR TVGSRSLRQR
     LQDTVGLCFP MRTYSKQSKP LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV
     SPHSTFFDTF DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG
     PKLAPGMTEI SGDSSAIPQA NCDSEEDTTT LCLQSRRQKQ RQISGDSHTH VSRQGAWKVH
     TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE GTFLLRDSAQ EDYLFSVSFR
     RYNRSLHARI EQWNHNFSFD AHDPCVFHSS TVTGLLEHYK DPSSCMFFEP LLTISLNRTF
     PFSLQYICRA VICRCTTYDG IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK
//
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