ID H2RJ48_TAKRU Unreviewed; 956 AA.
AC H2RJ48;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Aryl hydrocarbon receptor 2B {ECO:0000313|Ensembl:ENSTRUP00000000161.3};
GN Name=ahr2b {ECO:0000313|Ensembl:ENSTRUP00000000161.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000000161.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000000161.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000000161.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2RJ48; -.
DR STRING; 31033.ENSTRUP00000059510; -.
DR Ensembl; ENSTRUT00000000161.3; ENSTRUP00000000161.3; ENSTRUG00000000070.3.
DR eggNOG; KOG3560; Eukaryota.
DR GeneTree; ENSGT00940000154486; -.
DR TreeFam; TF352074; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0030522; P:intracellular receptor signaling pathway; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR GO; GO:0006805; P:xenobiotic metabolic process; IEA:InterPro.
DR CDD; cd19696; bHLH-PAS_AhR_like; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR039091; AHR/AHRR.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR PANTHER; PTHR10649; ARYL HYDROCARBON RECEPTOR; 1.
DR PANTHER; PTHR10649:SF17; ARYL HYDROCARBON RECEPTOR; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 11..64
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 124..181
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 956 AA; 104902 MW; 5E6B03710A0971C0 CRC64;
CGAQVCPKPP PPDGIKSNPS KRHRDRLNGE LDKLTSLLPF TEDVRSRLDK LSVLRLSVGY
LKVKSFFNAS IKNGQNGSSW NSERSIMFGK ISTPLPSSSN PSSSSGSSQS TSIDGVSFSE
GDLLLQALNG FVLVVTAEGY VFYTSPTIQD FLGFHQSDVI HQSVFELIHT DDRALFRRQL
HFAFIPTSSD QSSVEISTNV MAYDPQTIPP ENSSFLERNF CCRFRCLLDN SSGFLALNFH
GRLKFIHGQN RMAEDGTLVH PQLALFAVAT PMQPPSIVEI RAKTLIFQTK HKLDFTPMGI
DTRGKMVLGY NEVELCMKGS GYNFIHAADM MYCADNHIKM IKTGESGFTV FRLLAKSGTW
IWVQANARLV FKDGKPDFIV ARQKALTNEE GEEQLHLRRL QLPFNFATGE AMLYDVTPTI
EPPDPCSAPK QRKLDDSSVS PNSILGCMMN QDQSLYHNNT VGSIDDLAFK DTHATLSVPG
DAWLDTTFKH MTGSLTKSEA TVQDMMDSLQ QILGESELTR ALDVEPDELK SWESTLLKLS
TCDMSDDLSD ILSNDVLMYV EEQLQREGGL KVLDQLDDIL PCVAPLDLQS HNHEVPGQQN
FGWTGEPQNQ LLPNRGQLSF QLGAPVCGTM KLIHIDPPQL CSAGLDGPTL QHIGFQQSSG
LPGDACTLDQ SIVEDSGLGA FALRQPPANQ GHFNQMPPPT QNRHQMRTPA SLQDKNPVFS
SPGNHWSSNS NQVDHFVDSY ADNNPSQQGF AANPSSCLQG HFALQSQNSD RHKPSWSLDQ
QQLHHHASDG RQHVGACLNQ MPGFQRDPLH GVVTVQNAVN GASPFKNTET PNVAYAAQQN
VSSGTCMFGD VAPSSPSRHM LNPSAHQMGS KSSCLYRGLP GGVAVPGMAN VLNPDESTLT
CKTTMALGPE DLLVQQQQYL CFSDTHTQIN VHPVTGNGGF PFSSMPNGNA YYSENN
//
