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Database: UniProt
Entry: H2RLK4_TAKRU
LinkDB: H2RLK4_TAKRU
Original site: H2RLK4_TAKRU 
ID   H2RLK4_TAKRU            Unreviewed;      1769 AA.
AC   H2RLK4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000001017, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000001017}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000001017}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000001017}.
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DR   Ensembl; ENSTRUT00000001020; ENSTRUP00000001017; ENSTRUG00000000432.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028817; Na_channel_a4suB.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF186; PTHR10037:SF186; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    130    148       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    157    176       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    196    216       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    228    245       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    403    430       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    567    593       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    605    628       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    640    664       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    685    713       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    775    798       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1005   1023       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1043   1062       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1082   1108       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1207   1231       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1290   1308       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1320   1342       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1354   1373       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1410   1440       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1513   1536       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    436       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      576    803       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      811    959       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      965   1239       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1289   1546       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      427    462       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1769 AA;  201945 MW;  78F6B5B8EC1009DD CRC64;
     MRTLLPPVGS EVFRRFTQSS LNEIQQKQQI REEERKRTNA QVSEELPEPA SDLEAGKPLP
     FIYGEPPHEL LNVPLEDIDP FYQSQKTFIV LSKGNIIYRF NAESSLYLLS PFNALRIVAI
     KILIHSCKTL FSLFIMATIL TNCAFMTLSD PPAWSKIYRY VFTFIYTFEA TIKILSRGFC
     VGKFTFLKDP WNWLDFMVIS MAYLTELVDL GNVSVLRTFR VLRALKTITV IPGLKTIVGA
     LIQSVRKLAD AMVLTVFCLS VFALIGLQLF MGNLRQKCVL IPQWLYGNLT FDINSTNGYY
     GNDTHDNGTK SKHLEFEFER HINNPDNYYY LTGQGDPLLC GNSSDAGVCP ESYVCLKVGA
     NPNYGYTSYD SFGWAFLALF RLMTQDFWEN LFQLTLRTAG KTYMIFFVVV IFLGSFYLIN
     LILAVVAMAY AEQNEATLAE AKEKEEEYIH ILEALKKREE ERCGLVLGLF FLRSAASKGE
     NELLNHIFGG LSKKNLKNAF STIPSINQLI HNASVRELKD FNFSPVKMTL EQRQDDHRLC
     PPCWYAFANI FLKWDCCGCW RHLKECLYAI VMDPFVDLGI TICIILNTVF MAMEHYPMSA
     DFEELLSVGN LVFTGIFTGE MVFKILAMDP YFYFQVGWNI FDSIIVTISL VELGLANVQG
     LSVLRSFRLM RVFKLAKSWP TLNMLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK
     NYKDCVCRIS EDCVLPRWHM NDFFHAFLII FRVLCGEWIE SMWDCMEVSG QTMCLIVFMM
     VLVIGNLVVL NLFLALLLSS FSGDNLTTQD DEGENNLQIA INRINRAMSW TKTYILLYVY
     TLTESNLNQH FAALTSVSSD KLVSHHCGND FFRVPIAEAE SDSDDSDYDE DKDSQCDESS
     VCSSVQKPEV QEEEMDENCV AKTPTDCWTK KCYSRCPFLD IDTSQGRGKI WCNIRRTCFS
     IVENNYFESF IVFMILLSSG ALAFEDIYLE KHQLIKSILE YADKVFTYVF VMEMVLKWFA
     YGFKSYFSNA WCWLDFLIVD VSLVSLTANI LGYSELGAIK SLRTLRALRP LRALSRFEGM
     RVVVNALVGA VPSIFNVLLV CLIFWLIFSI MGVNLFAGKF SYCFNETSQE IIDTKVVDNK
     TECIALIKAN FTEVRWKNVK VNYDNVGIGY LSLLQVATFK GWTDIMYAAV DSRDVESQPI
     YEVNLYMYLY FVIFIIFGSF FTLNLFIGVI IDNFNQQKAK LGGQDIFMTE EQKKYYNAMK
     KLGSKKPQKP VPRPENPFQG LVFDLVTKQI FDVFIMVLIC LNMVTMMVET DEQSDKKEEV
     LYWINVVFIL IFTTECTLKI IALRRHYFSI GWNIFDFVVV ILSILGVSGL LLADIIEKYF
     VSPTLFRVIR LARIGRVLRL IRGAKGIRTL LFALMMSLPA LFNIGLLLFL IMFIFSIFGM
     SNFAYVKKEA LIDDMFNFET FGNSMICLFM ITTSAGWDGL LSPIMNTPPD CDPNVENPGT
     TVRGNCGSPA IGIAFFSTYI IMSFLVVVNM FIAIILENFN VATEESSDPL CEDDFEMFYE
     TWEKFDPDAS QFIQYSKLSD FCDTLKEPLR IPQPNTIKLI SMDLPLVPGD RIHCMDILLA
     LTAEVLGDSD EMDTLKATME EKFMANNPSK VSYEPISSTL LRKEEEVAAT VIQRAYRKYL
     LLRTVRLASF MYREKTEGRG KEKAPETTGL LCKQFSQLYG FNKETDEPLQ SKANRLGQVE
     LQSEVLLHAV PPLRSSEFLQ ERDQRETSV
//
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