GenomeNet

Database: UniProt
Entry: H2RMG0_TAKRU
LinkDB: H2RMG0_TAKRU
Original site: H2RMG0_TAKRU 
ID   H2RMG0_TAKRU            Unreviewed;      1897 AA.
AC   H2RMG0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   05-JUL-2017, entry version 41.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000001323, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000001323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000001323}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000001323}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   Ensembl; ENSTRUT00000001329; ENSTRUP00000001323; ENSTRUG00000000558.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     99    118       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    130    150       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    195    217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    229    247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    393    420       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    733    751       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    763    786       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    798    822       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    843    871       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    933    956       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1182   1202       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1223   1242       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1248   1270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1315   1335       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1383   1404       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1424   1447       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1506   1524       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1536   1554       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1566   1586       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1623   1651       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1727   1750       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      131    425       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      492    682       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      733    960       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      970   1176       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1180   1456       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1505   1760       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1764   1826       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      417    462       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1897 AA;  215241 MW;  B90BADE526DB6981 CRC64;
     KMAQLLVPPG PDSFRPFSRE SLKAIEARIT EEKARKPKGG KKKRSEENEL KPSSDLEAGK
     SLPLLYRDVP KSMVSIPLED MDPYYNNQKT FIVLNKGSYI FRFNAAPALY LLSPFNLLRR
     ISIRILVHSY PLISVVIMCT IIANCGFMTL DRPPEWAKNV EYTFTAIYTF ESLVKILARG
     FCLGKFTFLR DPWNWLDFSV IVMAYVTEFV NLGNFSVLRT FRVLRAFKAI SVIPGLKTIV
     SALFQSVKKL ADVMILTVFC LSVFALIGLQ LFMGHLKQKC VWILTNDSSV NETYANGTQV
     NQSHSFNLTE YMLDPKNHYY LPGKKDPLLC GNSSDAGRCP EGYVCKRVGA NPDYGYTSFD
     SFGWAFLSLF RLMTQDYWEN LYQQTLRASG KPYMIFFVLV IFLGSFYLIN LILAVVAMAY
     EEQCQATIQE AKEKEEEFKA MLEQLKRQQE DAQAVADAAV AEGGGVDGKG GGPESSSDAS
     KLSSKSAKER RNRRRKKKEE GKDEKFPQLE SQDSMKKARC RFSVDANQLN YDMKFSFTHQ
     SFLSFRGPLF SDRRNSRTSL FSSHSQTRDV GSETEFADDE NSIFEGNLNR RGSLFLPRSR
     DRRDSSMSQC SFLSHLLLPT SGIKRSSIDC NGVVSLIWPP PEIIMGDTTD TEYQGADGGP
     HQEFMDLLEG PEARQRAQSI ASVITSTMEE LEESRQKCPS CWYTFAETVL IWECCPVWMK
     FKKVVNLIVM DPFADLTITI CIVLNTLFMA MEHYPMSGSF SRMLTVGNVV FTCIFTAEMV
     LKIIALDPYY YFQTGWNIFD GIIVTLSLME LFLANVVGMS VLRSFRLLRV FKLAKSWPTL
     NTLIKIIGNS VGALGNLTLV LAIVVFIFAV VGMQLFGKNY RDCVCKISAN CELPRWHMSD
     FFHSFLIVFR VLCGEWIETM WDCMEVSGMT MCIILYMMVM VIGNLVVLNL FLALLLSSFS
     ADKMLANEDD SDTNNLQIAI ARIQRGIAFV KAFIQSRCRS ACLRGEKAGK AEDKSLDELH
     KPTGPNGVPN HTLKNFAKNG NGVDKSGDKY IVSSRSDDSI MSFINNPSLT ITVPIAVGES
     DFENLNTEDF SSVSSEAACH VNVEEDDDEY SSSEGSTVDC PLDGERGESV DFELDKAMEP
     DACFFDGCVQ RFQCCQVNVE AGWGKMWWTL RKTCYRIVEH SWFESFIIFM ILLSSGALIK
     ACEDINSEKR KTVKILLEFA DKIFTYIFIL EMLLKWVAYG FAKYFTNAWC WLDFLIVDVS
     LISLVANALG YSELGAIKSL RTLRALRPLR ALSRFEGMRV VVNALLGAIP SIFNVLLVCL
     IFWLIFSIMG VNLFAGKFRM CIRRTTNQPF LPTEVKTKND CINLGQDVAR WTNLKVNFDN
     VGLGYLALLQ VATFKGWTDL MYAAVDSQSK PDEQPDYEIN LKMYLYFVVF IIFGAFFTLN
     LFIGVIIDNF NQQKKKLGGQ DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP SNKIQGYIFD
     FTTKQAFDIV IMVLIWLNMV TMMVETADQS EEMGRILYNI NVVFIVIFTG ECLLKMISLR
     HYFFTNGWNI FDFIVVILSI IGVFLSELIE NYFVSPTLFR VIRLARIGRV LRLIKSAKGI
     RTLLFALMMS LPALFNIGLL LFLVMFIYAI FGMSNFAYVK KESDIDDMFN FETFGNSMLC
     LFQITTSGGW DKLLAPILNK HADDCDNSTE HPGSSVKGDC GNPPVGIAFF VSYIIICFLI
     VVNMYIAVIL ENFGVATEES ADPLSEDDFE MFYEVWERFD PRATQFMEYN KLSDFADSLD
     PPLCLPKPNK LELISMDLPM VSGERIHCLD ILFAFTKRVL GEGGEMDILR EQMEVRFMAS
     NPSKVSYEPI TTTLRRKLED TSATVIQRAY RQYASQR
//
DBGET integrated database retrieval system