ID H2RTH6_TAKRU Unreviewed; 953 AA.
AC H2RTH6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Disks large homolog 2 {ECO:0000313|Ensembl:ENSTRUP00000003443.3};
GN Name=LOC101064665 {ECO:0000313|Ensembl:ENSTRUP00000003443.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000003443.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000003443.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000003443.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR AlphaFoldDB; H2RTH6; -.
DR Ensembl; ENSTRUT00000003462.3; ENSTRUP00000003443.3; ENSTRUG00000001498.3.
DR GeneTree; ENSGT00940000155156; -.
DR Proteomes; UP000005226; Chromosome 15.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12032; SH3_DLG2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR035759; DLG2_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR015143; L27_1.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF6; DISKS LARGE HOMOLOG 2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF09058; L27_1; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM01277; MAGUK_N_PEST; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 4..64
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 234..321
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 329..416
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 509..590
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 637..707
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 763..938
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 95..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 953 AA; 106210 MW; 28D77C9BE0D11AD8 CRC64;
MPIRKNDTTR ALGLLDDYCT KLRRPEEQQL KTAIHRVMGI FQSNLFEALL DIQEFYEITL
LNTQKSCEQK LEEVNHMVDK WEKCVSVQHS ELGIPVSPVE AQRDQSSGEP SGMESDQHCT
SVNRPAAVQR SPHNGPPPPC MNPALTNTSW QYNYQDDDSP PHDQGFLRLT NEVTPELVHV
SEKNLSEIEN VHGYVSHSHI SPLKASPAPI IVNTDTLESL PYVNGTEIEY EFEEITLERG
NSGLGFSIAG GTDNPHIGDD PGIFITKIIP GGAAAEDGRL RVNDCILRVN DTDVSEVSHS
KAVEALKVAG SIVRLYVRRR RPMLETIIEI KLIKGPKGLG FSIAGGVGNQ HIPGDNSIYV
TKIIDGGAAQ KDGRLQIGDR LLMVNNYGLE EVSHEEAVAI LKNTSDVVYL KVGKPTNVYL
SDPYGPPDIA HSFSPAMENH ISSPINSGTL DYKTALPPIS PRSYSPLPRH LLGGEDINRL
DGFSFLRNSS LEDGDGHKFE PFQLREPRKV VLHKGSTGLG FNIVGGEDGE GIFVSFILAG
GPADLSGELK RGDQILSVNG IDLRGATHEQ AAVALKGAGQ VVTIIAQYRP EELALCSPQR
TPAPEYGRFE AKIHDLREQM MNHSMSSGSG SLRTNQKRSL YVRALFDYER SRDSGLPSQG
LSFKYGDILH VINASDDEWW QARRVTPHGD SEEMGVIPSK RRVERKERAR LKTVKFNAKP
GSLDSKGDFL GIGDEGYGTK TFRSQDDVIL SYEPVLRQEI TYVRPVIILG PMKDRINDDL
ISEFPEKFGS CVPHTTRPKR DYEVDGRDYH FVMSREQMEN DIQEHKFIEA GQYNDNLYGT
SVQSVKYVAE RGKHCILDVS GNAIKRLQVA QLYPIAILVK PRTIDSLMDM NKRLTEEQAR
KTFDRAMKLE QEFGEFFTAL VQGDTLEDIY NSCKQVIEEH SGPYIWIPSK EKL
//
