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Database: UniProt
Entry: H2RVE0_TAKRU
LinkDB: H2RVE0_TAKRU
Original site: H2RVE0_TAKRU 
ID   H2RVE0_TAKRU            Unreviewed;      1502 AA.
AC   H2RVE0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 42.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=LOC101064508 {ECO:0000313|Ensembl:ENSTRUP00000004108};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000004108, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000004108}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000004108}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in
CC       opposite effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   STRING; 31033.ENSTRUP00000004108; -.
DR   Ensembl; ENSTRUT00000004130; ENSTRUP00000004108; ENSTRUG00000001782.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H2RVE0; -.
DR   OMA; ACSYGKL; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005450; VDCC_L_a1ssu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF190; PTHR10037:SF190; 2.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01634; LVDCCALPHA1S.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     67     84       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    104    124       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    136    154       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    208    230       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    290    311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    323    345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    445    462       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    482    504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    511    531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    543    560       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    567    588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    642    668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    805    828       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    875    893       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    960    989       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1087   1112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1168   1188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1200   1222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1287   1310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1378   1402       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1418   1453       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      677    697       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1502 AA;  171454 MW;  77FEAE86376EA394 CRC64;
     MVGNSSPPLS SYIMDEDTLK RKQKEKLKKL MATGGNPRPA RSLLFLTLRN PFRKACLSIV
     EWKPFEIIIL LAIFANCVAL AVYLPMPEED SNNTNSNLES LEYIFLIIFS VECFLKIVAY
     GFLFHADAYL RNCWNILDFV CVSVGLFTVA MDAINHISGV EASIGDKGGG FDMKALRAFR
     VLRPLRLVSG VPSLQVVMNS ILKSMLPLFH ITLLVFFMVT IYSIMGLELF KCKMHKTCYY
     IGTNIIATVE NEKPAPCAQA GNGRRCLING TECRIGWPGP NQGITHFDNL GFSMLTVYQC
     ITTQGWTDVL YWVNDAIGME WPWIYFTTLI LVGSFFVLNL ILGVLSGEFT KEREKAKSRG
     EFQKLRETQQ LDEDLKGYME WITQAEVLDN EQESHGLLTT ENRGMENGRV GKMDTIQLIM
     YYYKVARKWN RWLRRKCRVC VKSRLFYWWV IMLVFLNTLA IATEHHKQTQ RLTNWQDNAN
     KLLLTMFFLE MFMKMYALGL PSYFMSLFNR LIFFIVLIYN QMLINVLHLN LPRLCILCNE
     TCIIYYRYWT SLSNLVASLL NSIRSIACLL LLLFLFIVIF SLLGMQVFGG KFNFTNQPKP
     RSTFDSFPQA LITVFQILTG EDWNAVMYDG IMAHGGPCIP GILVSIYFII LFVCGNFILL
     NVFLAIAVDN LAEAESLTLA QKEKAEERKR KKLLRANMPD KTPEEKANLA KKLAEQRAKG
     VEGIPTTAKL KVDEFEFNVN EIKDPFPPAD FPGDDEEEDP DIPQSPRPRP MADLQLKEES
     VPIPEATSFF IFGPRNKFRK LCHRIINATT FTNIILLFIL LSSISLAAED PIDPLSFRNQ
     VTKNSLLHFS KLIKSVCKSF RKCSDRATKQ RKIEVLAYAD IVFTSVFTAE IVLKMTTYGA
     ILHKGSFCRN SFNILDLLVV SVSLLSMGME SSAISVVKIL RVLRVLRPLR AINRAKGLKH
     VVQCVFVAVK TIGNIVLVTM LLDFMFACIG VQLFKGKFYS CTDPDKMIEE TCRGWYIKYQ
     EGALHEMEVC KRKWTNADLN FDNILNGMLA LFTISTFEGW PKILYKAIDS NSEDEGPLYN
     NRVAISIFFI IYLILIAFFM MNIFVGFVIV TFQEQGEQEY KNCELDKNQR QCVQYALKAR
     PLRCYIPKNP YQYQHCNQSD HVTHLSDMLN VIFTVLFTVE MVLKLMAFKA KGYFGDPWNV
     FDFVIVIGSV VDVILSEINA ALASSGGLYC LQGCNEVDPM QAIASSENLS VSVTFFRLFR
     VMRLVKLLNR SEGIRNLLWT FIKSLQALPY VALLILMLFF IYAVVGMQIF GKIAVVDGTY
     INRNNNFQTF PQAVLLLFRC ATGEAWHEVM LACMYGKKCD PKSDYLPGEE YTCGSNFAII
     YFMSFYMLCA FLIINLFVAV IMDNFDYLTR DWSILGPQHL DEFKKIWAEY DPEATGRIKH
     LDVVTLLRRI PPPLGFGKFC PHRIACKRLV SMNMPLNSDG TVTFNATLFA LVRTALKIKT
     EG
//
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