ID H2RYH2_TAKRU Unreviewed; 1896 AA.
AC H2RYH2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Plexin A2 {ECO:0000313|Ensembl:ENSTRUP00000005193.3};
GN Name=PLXNA2 {ECO:0000313|Ensembl:ENSTRUP00000005193.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005193.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005193.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005193.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR STRING; 31033.ENSTRUP00000061451; -.
DR Ensembl; ENSTRUT00000005224.3; ENSTRUP00000005193.3; ENSTRUG00000002260.3.
DR GeneTree; ENSGT01050000244850; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF37; PLEXIN-A2; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1240..1262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..507
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1266..1293
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1896 AA; 211583 MW; E7D4D3DE7FC3C1A7 CRC64;
ITRRTLSRIA KVGAIATIVG FWLLAIPAPS NGQTFTSFHP ERRDWVFNHL TVHQTTGALY
IGAVNRVYKL SGNLTLLVSH DTGPEDDNKA CYPPLIVQPC TEPLVSTNNV NKLLLIDYSQ
NRLLACGSLY QGVCKLLRLD DLFILVEPSH KKEHYLSSVN QTGTMYGVIV PSQGQDGTLF
IGTAVDGKQD YFPTISSRKL PRDPESSAML DYELHTDFVS SLIKIPSDTL ALVSHFDIYY
IYGFASGSFV YFLTVQPETP ENSMASSGST SDLFYTSRIV RLCKDDRKFH SYVSLPVGCV
KNGVEYRLLQ AAYLGKPGRV LANSLNISTQ DDVLFTVFSK GQKQFHRPPD DSALCVFTIR
HINARIKERL QSCYQGEGNL ELHWLLGKDV QCTKAPVPID DSFCGLDINQ PLGGSQLVTG
HALYTETRDR MTSVTSYVYN GYCVAFVGTK SGRLKKIRVD GPPHGGVQYE TMSVIKDGSP
VLRDMAFSLD RNYLYVMSER QVTQVPIESC EQYGTCGECL SSGDPHCGWC VLHNICSQRS
RCERAEEPYR FAASLNQCVK VSVYPDSIAV SEPSVPLLLK VSHVPDLSAG ITCSFGNLTE
VEGQVNGNQI LCVSPAAKDV PLIPTDQDWS GVELRLNSKE TGQMVISTEV KFYNCSVHQL
CLSCVNSAFR CHWCKYRNLC THDPSSCSFQ EGRVNASEDC PQLVRSEEIL IPAGEVKPIT
LKAKNLPQPQ SGQRGYECVL HIQGVSHRVT ALRFNSSSVQ CQNSSYLYEG MKISELPVDF
SVVWNGNFII DNPENIQVHL YKCAAQRDSC GMCLKAERKF QCGWCSGEGR CTLRHHCPPI
NPYTSHWLNL SSKNVKCTNP RITEVTPVAG PPEGGTRVTI HGTNLGLAFS DMVGNVEVAG
VRCTPVEDGY IIAEQIVCEM DPAPLDIRPG PVQLCVGECR PELRARSLQL YSFVTPTVTG
LSPSRGPESG GTKVTIMGEN LGAGSAVTVL FGNQTCEFFG RTMTEIVCYS APSLSGVGPV
QISVSVDRAQ IRESLTFDYI EDPTVQRIDP DWSIASGHTP LLVTGTNLDV VQEPRIRVKY
AGRESVNVCK VLNMTSMSCF APSLMVEYHP GLDTVKHADE FGFIFNNVQA LLVYNNTNLL
YYPNPYFEPL SSSGVLEQKP GSPIILKGRN LVPPAPGGVR LNYTVLIGET PCSVTVSESQ
LLCEPPNLTG QYKVMVQVGG LHISPGAVHI MSDSLLTLPA IVSIAAGGGL LLIIVILVLI
AYKRKSREND LTLKRLQMQM DNLESRVALE CKEAFAELQT DINELTSDLD RAGIPYLDYR
TYAMRVLFPG IDDHPVLREL EVPGNGQQNV EKALKVFGQL INNKVFLLTF IRTLEMQRSF
SMRDRGNVAS LIMTALQGRL EYATDVLKHL LSDLIDRNLA SKNHPKLLLR RTESVAEKML
TNWFAFLLHK FLKDCAGEPL FMLYCAIKQQ MEKGPIDAIT GEARYSLSED KLIRQQIEYK
TLILNCVNPD NENSPEIPVK VLNCDTITQV KEKILDAVYK NMPYSQRPRA VDMDLEWRQG
RMARVVLQDE DITTKIENDW KRLNTLLHYQ VSDRCVVALV PKQTSSYNIP SSASMSRTSI
SRYDSSFRYT GSPDSLRSRA PMITPDLESG VKVWHLVKNH EHGDQKEGDR GSKMVSEIYL
TRLLATKGTL QKFVDDLFET LFSTVHRGST LPLAIKYMFD FLDEQADRHG IHDTDVRHTW
KSNCLPLRFW VNVIKNPQFV FDIHKSSITD ACLSVVAQTF MDSCSTSEHR LGKDSPSNKL
LYAKDIPNYK SWVERYYADI NRLPAISDQD MNAYLAEQAR LHSTEFNMLS ALNEIYSYIS
KYSEEITMAL EQEEQARKQR LSYKVEQLIS AMSFES
//
