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Database: UniProt
Entry: H2RZB2_TAKRU
LinkDB: H2RZB2_TAKRU
Original site: H2RZB2_TAKRU 
ID   H2RZB2_TAKRU            Unreviewed;      1969 AA.
AC   H2RZB2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   30-AUG-2017, entry version 40.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=LOC101061091 {ECO:0000313|Ensembl:ENSTRUP00000005483};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005483, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000005483}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000005483}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000005483}.
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DR   STRING; 31033.ENSTRUP00000005483; -.
DR   Ensembl; ENSTRUT00000005516; ENSTRUP00000005483; ENSTRUG00000002374.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H2RZB2; -.
DR   OMA; FTIVEHD; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    225    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    368    387       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    407    434       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    639    665       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    711    728       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    740    759       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    779    800       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    821    849       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    879    899       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    911    934       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1155   1173       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1194   1210       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1222   1241       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1286   1306       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1396   1419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1478   1496       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1508   1530       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1542   1561       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1609   1631       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1699   1722       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1739   1774       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      431    465       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1969 AA;  221466 MW;  BAF9556B5AACBCEC CRC64;
     MATILPPPGT ALFRHFTRQS LATIERLKEE TLIAPKAGAH EEEEPPTPNP DLEAGKSLPM
     IFGDPPSELL GTPLEDIDPF YKAQKTFVVV TKGNTIYRFN AEPACYILSP FSLVRRGAIK
     ILIHSYPFAQ LFGTLIMITI LSNCVFMTMS NPPAWSKTVE YVFTGIYTFE ATVKVLSRGF
     CVGPFTFLRD PWNWLDFMVI SMAYITEFVD LGNVSALRTF RVLRALKTIT VIPGLKTIVA
     ALIQSVKKMV DVMILTVFAL AVFALVGLQL FMGNLRHKCI RWPIANETAS ELFNGTVFND
     TLSYNDTTWL NDTLDSNSTF DFTEYIENAE NQYFLEGSKD ALLCGNSTDA GKCPEGYLCM
     KAGRNPNYGY TSFDSFGWAF LALFRLMTQD NWESLFQLTL RAAGQTYMLF FVVVIFLGSF
     YLINLILAVV AMAYDEQNQA SQQEAKEKEE EFQRLLEQLK NQEQIKRKHL KLHLVFNSLK
     QAQVLGSRAS LTSKKSVSLT GSDVADDEQS LENNEALKDC NGRPIPRLII RAPTMKEVSL
     SPRVGFIVKI FPHCGPATGR SSAADYELRE KEESSVHSVL HLDEPGLRER SASVATAAAS
     VATAAASVAT AAAMEGKVPI KTTISKGCHE ERPQYSSVFV GLLIVGIITF CAEKSLTAAS
     VVTLWCLELE EAQRPCPPIW YRFADIFLKW NCCEKWVVFK KWVHFVVMDP FVDLAITICI
     VLNTLFMAME HYPMTEEFDY MLSVGNLVFT GIFAAEMFFK LIAMDPYYYF QVGWNIFDSI
     IVTLSLVELG LANVQGLSVL RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA
     IIVFIFAVVG MQLFGKSYKD CVCKISSDCE LPRWHMNDFF HSFLIVFRIL CGEWIETMWD
     CMEVAGAGMC LVVFMMVMVI GNLVVLNLFL ALLLSSFSGD NLSVGDDDGE LNNLQIAIGR
     ITRGGNWLKA FLIGTVQRVL GREPQKPAEE DPADEGEGKT EGMEMNHLDG FKLADGIANC
     LVGGQPSGVT LDGESSITVP IALGESDSEN PSEDDDDQED DVDSEVTCEE NEHHSLMGAL
     TDGDSSVCST VDYQPPEPEV QEEEEEEPDL VEPEACFTDN CVKRWPCLNV DISQGKGKKW
     WNLRKTCFTI VEHDWFETFI IFMILLSSGA LAFEDIYIER RRTVKIVLEF ADKVFTFIFV
     IEMLLKWVAY GFKTYFTNAW CWLDFFIVDI SLISLSANLM GFSDLGPIKS LRTLRALRPL
     RALSRFEGMR VVVNALIGAI PSIFNVLLVC LIFWLIFSIM GVNLFAGKFY RCINTTTAEL
     FPISVVNNKS DCVALQEATQ EARWVNVKVN YDNVAKGYLS LLQIATFKGW MDIMYPAVDS
     REVEEQPSYE INLYMYIYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKLG DKDIFMTEEQ
     KKYYEAMKKL GSKKPQKPIP RPANLIQGLV FDFISQQFFD IFIMVLICLN MVTMMVETDD
     QSPAKEDFLF KVNVAFIVVF TGECTLKLFA LRHYFFTNGW NIFDFIVVIL SIAGTMLSDI
     IEKYFVSPTL FRVIRLARIG RILRLIKGAR GIRTLLFALM MSLPALFNIG LLLFLIMFIF
     SIFGMSNFAY VKKEAGINDM FNFETFGSSI ICLFQITTSA GWDTLLLPML NKEPPDCDPA
     FENPGTDVKG NCGNPMMGMV FFCSYIIISF LVVVNMYIAI ILENFNVAQE ESGDVLCEED
     FEMFNETWEK FDTGGTQFIE YSQLSDFCDA LQEPLRVAKP NRQRLIEMDL PLVIGDRIHC
     VDVLLAVTQE VLGDTIEMVA MRESIEAKFN LNNPTSASYA PITTTVRQKE EDMAAVVIQR
     AYRNHLHKRG IHHAAYIQRS KTGRKAASED APEKEGLLAK KMGALYGSDA DLADEVEGLR
     RRPDPQTRCS GARCSPEPPE PNIILVPVEI TNELLLHSAP SQQSSPTQT
//
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