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Database: UniProt
Entry: H2RZB3_TAKRU
LinkDB: H2RZB3_TAKRU
Original site: H2RZB3_TAKRU 
ID   H2RZB3_TAKRU            Unreviewed;      1782 AA.
AC   H2RZB3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   30-AUG-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=LOC101061091 {ECO:0000313|Ensembl:ENSTRUP00000005484};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005484, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000005484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000005484}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000005484}.
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DR   Ensembl; ENSTRUT00000005517; ENSTRUP00000005484; ENSTRUG00000002374.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    126    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    194    213       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    225    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    368    387       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    407    434       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    565    582       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    594    613       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    633    654       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    675    703       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    765    788       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    999   1017       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1038   1054       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1066   1085       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1130   1150       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1240   1263       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1322   1340       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1352   1374       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1386   1405       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1453   1475       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1543   1566       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1583   1618       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      431    465       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1782 AA;  201241 MW;  D6C1CB7130DC136F CRC64;
     LCDAKMATIL PPPGTALFRH FTRQSLATIE RLKEETLIAP KAGAHEEEEP PTPNPDLEAG
     KSLPMIFGDP PSELLGTPLE DIDPFYKAQK TFVVVTKGNT IYRFNAEPAC YILSPFSLVR
     RGAIKILIHS LFSTLIMITI LSNCVFMTMS NPPAWSKTVE YVFTGIYTFE ATVKVLSRGF
     CVGPFTFLRD PWNWLDFMVI SMAYITEFVD LGNVSALRTF RVLRALKTIT VIPGLKTIVA
     ALIQSVKKMV DVMILTVFAL AVFALVGLQL FMGNLRHKCI RWPIANETAS ELFNGTVFND
     TLSYNDTTWL NDTLDSNSTF DFTEYIENAE NQYFLEGSKD ALLCGNSTDA GKCPEGYLCM
     KAGRNPNYGY TSFDSFGWAF LALFRLMTQD NWESLFQLTL RAAGQTYMLF FVVVIFLGSF
     YLINLILAVV AMAYDEQNQA SQQEAKEKEE EFQRLLEQLK NQEQVKVARY NYELREKEES
     SVHSVLHLDE PGLRERSASV ATAAASVATA AASVATAAAM EELEEAQRPC PPIWYRFADI
     FLKWNCCEKW VVFKKWVHFV VMDPFVDLAI TICIVLNTLF MAMEHYPMTE EFDYMLSVGN
     LVFTGIFAAE MFFKLIAMDP YYYFQVGWNI FDSIIVTLSL VELGLANVQG LSVLRSFRLL
     RVFKLAKSWP TLNMLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK SYKDCVCKIS
     SDCELPRWHM NDFFHSFLIV FRILCGEWIE TMWDCMEVAG AGMCLVVFMM VMVIGNLVVL
     NLFLALLLSS FSGDNLSVGD DDGELNNLQI AIGRITRGGN WLKAFLIGTV QRVLGREPQK
     PAEEDPADEG EGKTEGMEMN HLDGFKLADG IANCLVGGQP SGVTLDGESS ITVPIALGES
     DSENPSEDDD DQEDDVDSEL MGALTDGDSS VCSTVDYQPP EPEVQEEEEE EPDLVEPEAC
     FTDNCVKRWP CLNVDISQGK GKKWWNLRKT CFTIVEHDWF ETFIIFMILL SSGALAFEDI
     YIERRRTVKI VLEFADKVFT FIFVIEMLLK WVAYGFKTYF TNAWCWLDFF IVDISLISLS
     ANLMGFSDLG PIKSLRTLRA LRPLRALSRF EGMRVVVNAL IGAIPSIFNV LLVCLIFWLI
     FSIMGVNLFA GKFYRCINTT TAELFPISVV NNKSDCVALQ EATQEARWVN VKVNYDNVAK
     GYLSLLQIAT FKGWMDIMYP AVDSREVEEQ PSYEINLYMY IYFVIFIIFG SFFTLNLFIG
     VIIDNFNQQK KKLGDKDIFM TEEQKKYYEA MKKLGSKKPQ KPIPRPANLI QGLVFDFISQ
     QFFDIFIMVL ICLNMVTMMV ETDDQSPAKE DFLFKVNVAF IVVFTGECTL KLFALRHYFF
     TNGWNIFDFI VVILSIAGTM LSDIIEKYFV SPTLFRVIRL ARIGRILRLI KGARGIRTLL
     FALMMSLPAL FNIGLLLFLI MFIFSIFGMS NFAYVKKEAG INDMFNFETF GSSIICLFQI
     TTSAGWDTLL LPMLNKEPPD CDPAFENPGT DVKGNCGNPM MGMVFFCSYI IISFLVVVNM
     YIAIILENFN VAQEESGDVL CEEDFEMFNE TWEKFDTGGT QFIEYSQLSD FCDALQEPLR
     VAKPNRQRLI EMDLPLVIGD RIHCVDVLLA VTQEVLGDTI EMVAMRESIE AKFNLNNPTS
     ASYAPITTTV RQKEEDMAAV VIQRAYRNHL HKRGIHHAAY IQRSKTGRKA ASEDAPEKEG
     LLAKKMGALY GSDADLADEV EGLRRRPDPQ TRCSGARCSP EP
//
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