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Database: UniProt
Entry: H2RZU5_TAKRU
LinkDB: H2RZU5_TAKRU
Original site: H2RZU5_TAKRU 
ID   H2RZU5_TAKRU            Unreviewed;      2037 AA.
AC   H2RZU5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   SubName: Full=Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a {ECO:0000313|Ensembl:ENSTRUP00000005666};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005666, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000005666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000005666}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000005666}.
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DR   Ensembl; ENSTRUT00000005701; ENSTRUP00000005666; ENSTRUG00000002449.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    129    148       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    160    182       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    364    385       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    397    415       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    490    512       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    565    590       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1078   1097       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1117   1138       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1150   1168       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1212   1234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1323   1348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1402   1419       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1431   1457       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1463   1486       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1498   1522       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1538   1573       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      586    613       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2037 AA;  230738 MW;  D9743DCCEED01057 CRC64;
     MARFGDEVPA RYGGGPGGGG PGGRGGSRQG GPHGHGHGHG HGHGHGPPGG PGTQRMYKQS
     MAQRARTMAL YNPIPVRQNC FTVNRSLFIF SEDNFVRKYA KKITEWPYPL APVKNIWSKL
     IVRRIDRKLA ILTVFQCITM EGWTELLYWS NDASGSAWNW MYFIPLIIIG SFFMLNLVLG
     VLSGEFAKER ERVENRREFL KLRRQQQIER ELNGYLEWIC KAEEVILADD ENEKDYDGIY
     AHQYDLLLRA TKNHKSKAEL LNQEEGEGDL AVGKINILSL CLSRCLRILS SFSNFSTSYS
     FLWFCTHMQG KSCPSCGTQF AFFILPGSPF ARASLKSSKL EGSTFKRRER RLRFLIRRVV
     KSQAFYWTVL CLVGLNTMCV AVVHYDQPEP LSDFLNFAEF VFLGIFLTEM FVKMYGLGRQ
     AYLNSSFNCF DCIVICGSIF EVLWSIIQPG TSFGISVLRA LRLLRIFKVT KYWASLRNLV
     VSLLNSMKSI ISLLFLLFLF IVVFALLGMQ LFGGQFNFEN GTPPTNFDTF PAAIMTVFQI
     LTGEDWNMVM YDGIKSQGGV HKGMAFSVFF IVLTLFGNYT LLNVFLAIAV DNLANAQELT
     KDEQEEEEAA SQKIALQKAK EVAEVSPLSA ANLSIAAKEQ QKNHNKGVNK SVWEQRTKEL
     RRQTLVSSRE ALYNELDPDE RWKARAGREE HNNVNFSRQV RPDMKTHLDR PLVVDPHENR
     NNNTNKMTAN NPDLCFSQQL PVEELHRQTR LHDHGGQVGA GCGVGSTDPA GPPLERGEST
     ESRRGQKGEH HHHGSHVRLD ATAIPRPGSE DRPSRRHHHT RSGSRGGGQS EHRKSRSHRK
     CTEDGEEGRG GAVKTGRHRT KGVDGGGETA EQDGAVDGGE RRQRRSRHLN QMDGEGRRTC
     QHRRKDFSAP NLSTTRPIQK SLSRQDSQYS EDMDNLMNTK LVSSSNLANE VHSNPAINRT
     VTPGFGSTLH LANSGTHGSL TTLDNYGSIV HHRANSVIRL PHPDYTAVDM PIFPSTNAIL
     QVNKNANTEP LPAKEDMDED DDDKAGEGGP RPMPPYTSMF ILTTTNPFRR ACHYVCTLRY
     FEMCILLVIA MSSIALAAED PVWPDSPRNN VLRYFDYVFT GVFTFEMLIK MVDLGLVLHQ
     GSYFRDLWNI LDFIVVSGAL VAFAFTGSSK GKDISTIKSL RVLRVLRPLK TIKRLPKLKA
     VFDCVVNSLK NVLNILIVYL LFMFIFAVVA VQLFKGRFFY CTDESKEFER DCRGEYLVYD
     NEVKAQKREW KKYDFHYDNV AWALLTLFTV STGEGWPQVL KHSVDATYEN QGPSPGYRME
     MSIFYVVYFV VFPFFFVNIF VALIIITFQE QGDKMMEDYS LEKNERACID FAINARPLTR
     HMPQNKLSFQ YRMWEFVVSP PFEYTIMAMI ALNTVVLMMK YDEASKSYEA VLANLNIVFT
     SLFSMECVLK IIAFGVLNYF KDGWNIFDCV TVLGSITDIL VTELGVRNAD PECGSQFAYL
     YFVSFIFFCS FLMLNLFVAV IMDNFEYLTR DSSILGPHHL EEYVRIWAEY DPAACGRISC
     REMYDMLRHM CPPLGLGRRC ARVAYKRLLR MDLPVADDNT VHFNSTLMAL IRTALDIKIA
     KISEGGIDKH QMDAELRKEM MAIWPNLSQK HLDLLVTPHK SATDLTVGKI YAAMMIMEYY
     RQSKIKRSQA LRDEQNRTPL LFQRVEPLPS QDGDPGLNNA LPPPETADNV NSLSVEGGLP
     ESHSWMTARA QEMSQKIGSW SPEGLPEDGL GSMTNSQTVE MRELGQDGYS DTDHFPPMEG
     HGRAASMPRL PGDNQQRRRG KQRGSTLSTI SDNSPMKRSA SSLGHSRSGR GHRDRGGVDD
     YGMERVIPEE GRPYRHGHRR KERSHRASER SLCRYADGDT GLGTDLGTTT QSGDIQSKDR
     DRDRDRGRSK DRKHHHHHHH HHGSVDKERY TAERGGEYAH RHSHDRGEER ERDRRWSRSP
     SEGRECMMHR QGSSSVSGSP VPSTSGTSTP RRGRRQLPQT PATPRPHVTY SPVVRKA
//
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