ID H2RZU8_TAKRU Unreviewed; 2263 AA.
AC H2RZU8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha-1A {ECO:0000256|ARBA:ARBA00039688};
DE AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.1 {ECO:0000256|ARBA:ARBA00041622};
GN Name=CACNA1A {ECO:0000313|Ensembl:ENSTRUP00000005669.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000005669.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000005669.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000005669.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. CACNA1A subfamily. {ECO:0000256|ARBA:ARBA00037936}.
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DR STRING; 31033.ENSTRUP00000005669; -.
DR Ensembl; ENSTRUT00000005704.3; ENSTRUP00000005669.3; ENSTRUG00000002449.3.
DR GeneTree; ENSGT00940000156518; -.
DR HOGENOM; CLU_000540_0_2_1; -.
DR InParanoid; H2RZU8; -.
DR OMA; KRMCQHR; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF3; VOLTAGE-DEPENDENT P_Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1093..1112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1132..1153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1165..1183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1227..1249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1338..1363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1417..1434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1446..1472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1540..1558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1630..1654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1670..1705
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1883..2263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 705..732
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 826..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..908
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..977
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1907..1939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1940..1969
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1994..2028
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2039..2070
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2139..2189
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2195..2225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 325
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 663
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1309
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 2263 AA; 255330 MW; C68805E679B723E4 CRC64;
MARFGDEVPA RYGGGPGGGG PGGRGGSRQG GPHGHGHGHG HGHGHGPPGG PGTQRMYKQS
MAQRARTMAL YNPIPVRQNC FTVNRSLFIF SEDNFVRKYA KKITEWPYPL WMILATIIAN
CIVLALEQHL PDGDKTPLSE RLDDTEPYFI GIFCFESGIK ILALGFAFHK NSYLRNGWNV
MDFVVVLTGI LSTMGSDFDL RTLRAVRVLR PLKLVSGIPS LQVVLKSIMK AMIPLLQIGL
LLFFAILMFA IIGLEFYMGK FHQTCFDNQT FEIREDFPCG EFPPSRLCPE GTVCRKNWLG
PNYGITQFDN IFFAILTVFQ CITMEGWTEL LYWSNDASGS AWNWMYFIPL IIIGSFFMLN
LVLGVLSGEF AKERERVENR REFLKLRRQQ QIERELNGYL EWICKAGALR AQDALCLCSR
RRATKNHKSK AELLNQEEGE GDLAVGSPFA RASLKSSKLE GSTFKRRERR LRFLIRRVVK
SQAFYWTVLC LVGLNTMCVA VVHYDQPEPL SDFLNFAEFV FLGIFLTEMF VKMYGLGRQA
YLNSSFNCFD CIVICGSIFE VLWSIIQPGT SFGISVLRAL RLLRIFKVTK YWASLRNLVV
SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFENG TPPTNFDTFP AAIMTVFQIL
TGEDWNMVMY DGIKSQGGVH KGMAFSVFFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK
DEQEEEEAAS QKIALQKAKE VAEVSPLSAA NLSIAAKEQQ KNHNKGVNKS VWEQRTKELR
RQTLVSSREA LYNELDPDER WKVNFSRQVR PDMKTHLDRP LVVDPHENRN NNTNKMTANN
PDLCFSQQLP VEELHRQTRL HDHGGQVGAG CGVGSTDPAG PPLERGESTE SRRGQKGEHH
HHGSHVRLDA TAIPRPGSED RPSRRHHHTR SGSRGGGQSE HRKSRSHRKC TEDGEEGRGG
AVKTGRHRTK GVDGGGETAD IVHHRANSVI RLPHPDYTAV DMPIFPSTNA ILQGKGGKIQ
IEKKSRHFLD ICVLHLVNKN ANTEPLPAKE DMDEDDDDKA GEGGPRPMPP YTSMFILTTT
NPFRRACHYV CTLRYFEMCI LLVIAMSSIA LAAEDPVWPD SPRNNVLRYF DYVFTGVFTF
EMLIKMVDLG LVLHQGSYFR DLWNILDFIV VSGALVAFAF TGSSKGKDIS TIKSLRVLRV
LRPLKTIKRL PKLKAVFDCV VNSLKNVLNI LIVYLLFMFI FAVVAVQLFK GRFFYCTDES
KEFERDCRGE YLVYDNEVKA QKREWKKYDF HYDNVAWALL TLFTVSTGEG WPQVLKHSVD
ATYENQGPSP GYRMEMSIFY VVYFVVFPFF FVNIFVALII ITFQEQGDKM MEDYSLEKNE
RACIDFAINA RPLTRHMPQN KLSFQYRMWE FVVSPPFEYT IMAMIALNTV VLMMKYDEAS
KSYEAVLANL NIVFTSLFSM ECVLKIIAFG VLNYFKDGWN IFDCVTVLGS ITDILVTELG
DNFINLSFLR LFRAARLIKL LRQGETIRIL LWTFVQSFKA LPYVCLLIAM LFFIYAIIGM
QLFGNIAIEE DDENAINQHN NFRTFIQALM LLFRSATGEA WHEIMLACLG NKECDPLSGN
ADPECGSQFA YLYFVSFIFF CSFLMLNLFV AVIMDNFEYL TRDSSILGPH HLEEYVRIWA
EYDPAACGRI SCREMYDMLR HMCPPLGLGR RCPARVAYKR LLRMDLPVAD DNTVHFNSTL
MALIRTALDI KIAKISEGGI DKHQMDAELR KEMMAIWPNL SQKHLDLLVT PHKSATDLTV
GKIYAAMMIM EYYRQSKIKR SQALRDEQVL RSSGTISSFS LLKSACRGRN ESLNSTAHED
FREQLQHLLL CLQTVEMREL GQDGYSDTDH FPPMEGHGRA ASMPRLPGDN QVSSILTYPP
STISDNSPMK RSASSLGHSR SGRGHRDRGG VDDYGMERVI PEEGRPYRHG HRRKERSHRA
SERSLCRYAD GDTGDSSVSG SPVPSTSGTS TPRRGRRQLP QTPATPRPHV TYSPVVRKAM
PTPPGPQTRP PAPAPRHFSP EPPPAQGPLP AGLPVAHHGT PRHIHHPPPR WPDTGGGGSM
EAGGCFYNQE YQDFEPHHEP PAYEQNPMQV VNPHGHIMAG HPLPPPPQPQ PHNPHPLPPP
QPHLVNNPHP HPPPHPQPSR TPPRTVHHVP PPTTALTGPL QSQMQSAAQR RLPNGYRSSS
PSALLHGPPH TGPHKIPPPA GHPRGPRKGL HEPYSETEED DWC
//
