ID H2S341_TAKRU Unreviewed; 845 AA.
AC H2S341;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=RNA binding motif protein 15 {ECO:0000313|Ensembl:ENSTRUP00000006813.2};
GN Name=RBM15 {ECO:0000313|Ensembl:ENSTRUP00000006813.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000006813.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000006813.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000006813.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RRM Spen family.
CC {ECO:0000256|ARBA:ARBA00005387}.
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DR RefSeq; XP_003963256.1; XM_003963207.2.
DR AlphaFoldDB; H2S341; -.
DR SMR; H2S341; -.
DR STRING; 31033.ENSTRUP00000006813; -.
DR Ensembl; ENSTRUT00000006858.3; ENSTRUP00000006813.2; ENSTRUG00000002921.3.
DR GeneID; 101071941; -.
DR KEGG; tru:101071941; -.
DR CTD; 64783; -.
DR eggNOG; KOG0112; Eukaryota.
DR GeneTree; ENSGT00940000158161; -.
DR HOGENOM; CLU_012724_1_0_1; -.
DR InParanoid; H2S341; -.
DR OMA; EWPNPAI; -.
DR OrthoDB; 2873387at2759; -.
DR TreeFam; TF354224; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR CDD; cd12553; RRM1_RBM15; 1.
DR CDD; cd12555; RRM2_RBM15; 1.
DR CDD; cd12557; RRM3_RBM15; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034470; RBM15_RRM1.
DR InterPro; IPR034472; RBM15_RRM2.
DR InterPro; IPR034473; RBM15_RRM3.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR012921; SPOC_C.
DR InterPro; IPR010912; SPOC_met.
DR PANTHER; PTHR23189; RNA RECOGNITION MOTIF-CONTAINING; 1.
DR PANTHER; PTHR23189:SF43; RNA-BINDING PROTEIN 15; 1.
DR Pfam; PF00076; RRM_1; 3.
DR Pfam; PF07744; SPOC; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR PROSITE; PS50102; RRM; 3.
DR PROSITE; PS50917; SPOC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 122..199
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 298..375
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 379..453
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 671..844
FT /note="SPOC"
FT /evidence="ECO:0000259|PROSITE:PS50917"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 845 AA; 94232 MW; 67D6BF5D9158A10B CRC64;
MKGKERSPIK KRSRALDDIR DRGGCHPTNK KMGPLSGSSG SNNGNSSTKS DGGSTRRSLL
IEKRDRDFDA HSRTGNNHSL NATGGSVGKN HSLSLTLDLS SARAALRGEQ RVQSPGGESE
YKTLKISDLG TQLSDEDVED GLFHEFKKFG DVSVKISRSN DERIAFVNFR KPEDARAAKH
ARGRLVLYDR PLKIEAVYIN RRRSRSPVER DLYGAAQSHR HLQRPLSPTG LGYRDYRLQQ
LALGRLPPPP PPPLPRELDR DREFALFEAR TRPAFIAERA AFREEDFISP EDDQRANRTL
FLGNLDITVT EADLRRAFDR FGVITEVDIK RPTRGQVSTY GFLKFENLDM AHRAKLSMSG
KVVGRNPIKI GYGKATPSTR LWVGGLGPWV PLAALAREFD RFGTIRTIDY RKGHTWAYIQ
YESLDAAQAA CTHMRGFPLG GPERRLRVDF ADNEHRYQQQ FLQPLPIPPF DMVAESFVHR
ATPEPLRVRE RTPPPLHFRE RELFPGTEWP NPAIRERVRA SPFETIDHLE RRTREAWSLE
RELQGREPAR KRRVTEDGRH ADHSPDSSER TARRRRASPD GSPGGSSRDG GRFSDSERPL
RGDRASPTRE HHSGLERSGV ERRTKSLSLA EKGPLSTGVS SVERKRKVGD GGKGLAKRER
SEGSIKAGQL SKLDDSKLVM AWNGMLLLKN SNFPANMHLL EGDHNVASEL LVDGSTGRQV
SELKITQRLR LDQPKLDEVS RRIKVAGPGG YAILLAVPGA TEDPSSSDAA STQRPLRNLV
SYLNQKQAAG VISLPVGGSK DKDTTGVLHA FPPCDFSQQF LDSSAKALAK SKEDYLVMIV
VRGAS
//