ID H2S5N7_TAKRU Unreviewed; 316 AA.
AC H2S5N7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Zinc finger Ran-binding domain-containing protein 2 {ECO:0000256|ARBA:ARBA00017543, ECO:0000256|PIRNR:PIRNR037956};
GN Name=zranb2 {ECO:0000313|Ensembl:ENSTRUP00000007709.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000007709.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000007709.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000007709.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May interfere with constitutive 5'-splice site selection.
CC {ECO:0000256|PIRNR:PIRNR037956}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR037956}.
CC -!- SIMILARITY: Belongs to the ZRANB2 family.
CC {ECO:0000256|ARBA:ARBA00025731, ECO:0000256|PIRNR:PIRNR037956}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003974317.1; XM_003974268.2.
DR AlphaFoldDB; H2S5N7; -.
DR STRING; 31033.ENSTRUP00000007709; -.
DR Ensembl; ENSTRUT00000007756.3; ENSTRUP00000007709.2; ENSTRUG00000003300.3.
DR GeneID; 101077888; -.
DR KEGG; tru:101077888; -.
DR CTD; 9406; -.
DR eggNOG; KOG1995; Eukaryota.
DR GeneTree; ENSGT00730000111078; -.
DR InParanoid; H2S5N7; -.
DR OMA; DLWGDNE; -.
DR OrthoDB; 585295at2759; -.
DR TreeFam; TF105996; -.
DR Proteomes; UP000005226; Chromosome 20.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030882; F:lipid antigen binding; IEA:Ensembl.
DR GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 2.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR InterPro; IPR017337; ZRANB2.
DR PANTHER; PTHR12999:SF17; ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR12999; ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 ZRANB2-RELATED; 1.
DR Pfam; PF00641; zf-RanBP; 2.
DR PIRSF; PIRSF037956; UCP037956_ZnF_Ran; 1.
DR SMART; SM00547; ZnF_RBZ; 2.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 2.
DR PROSITE; PS01358; ZF_RANBP2_1; 2.
DR PROSITE; PS50199; ZF_RANBP2_2; 2.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR037956}; Nucleus {ECO:0000256|PIRNR:PIRNR037956};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR037956};
KW Zinc {ECO:0000256|PIRNR:PIRNR037956};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 9..40
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 65..94
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 113..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..190
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..295
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 316 AA; 35148 MW; C6F111D63D8AC7CD CRC64;
MSGKSFRVSD GDWICPDKKC GNVNFARRTS CNRCGRDKTT DAKMMKAGGT EIGKTLAEKS
RGLFSANDWQ CKTCGNVNWA RRSECNMCNT PKYAKLEERT GYGGGFNERE NIEYIEREES
DGEYDEFGRK KKKFRGKSSS TSSSKETEKK EVKKDEEEDE EDDEEDGDVS KYKLDDDDDE
DEDGDLSKYD LDASDEDADK AAKKKGSHSD SSRSSSRSSS SSSRSRSRSR SRSSSSSRSG
SRSRSRSRSS SRSGKGSSPQ KRSRSPSSSP EGRQKRSRSR SSSGGRKRRR SRSRSSERSR
GQSSGSSHSG SSSKKK
//
