ID H2SA75_TAKRU Unreviewed; 371 AA.
AC H2SA75;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=G protein-coupled receptor 27 {ECO:0000313|Ensembl:ENSTRUP00000009301.1};
GN Name=gpr27 {ECO:0000313|Ensembl:ENSTRUP00000009301.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000009301.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000009301.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000009301.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_003973809.1; XM_003973760.2.
DR AlphaFoldDB; H2SA75; -.
DR Ensembl; ENSTRUT00000009356.3; ENSTRUP00000009301.1; ENSTRUG00000003935.3.
DR GeneID; 101070776; -.
DR KEGG; tru:101070776; -.
DR CTD; 2850; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00890000139436; -.
DR HOGENOM; CLU_055518_0_0_1; -.
DR InParanoid; H2SA75; -.
DR OMA; NPIISFM; -.
DR OrthoDB; 2962814at2759; -.
DR TreeFam; TF331163; -.
DR Proteomes; UP000005226; Chromosome 19.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15005; 7tmA_SREB-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR19268; G PROTEIN-COUPLED RECEPTOR; 1.
DR PANTHER; PTHR19268:SF8; G-PROTEIN COUPLED RECEPTOR 27-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..340
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 371 AA; 41401 MW; 682D994EFC01C297 CRC64;
MANASEFGGS SPSFHNYAST ACALKLASLG LILGISLLGN AALSLLLLKD SSLHKAPYYF
LLDLCLADVL RAAVCFPFVM ASIGGGSSWP YGALSCKLVA FMSVLFCFHV AFLLFCVSVT
RYMAIAHHRF YYKRMNLCTC AAVICMVWTL SVAMAFPPVF DVGTYKFIRE EEQCIFEHRY
VKANDTMGFM LMLAVIVFMT HVVYIKMFCF VYDHRKMKPA QLVPAISQNW TFHGPGATGQ
AAANWIAGFG RGPTPPTLVG IRQAAHLSNR RLLVLDEFKM EKRIGKMYYM ITLTFLIMWA
PYLSACFLRI FVRGASVAQL YLTAAVWMSF AQAGANPIIS FLFNKELRLR LRACFPCCLG
TQTPMEPYCV I
//
