ID H2SAI4_TAKRU Unreviewed; 320 AA.
AC H2SAI4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=tRNA N(3)-methylcytidine methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037755};
GN Name=LOC101065111 {ECO:0000313|Ensembl:ENSTRUP00000009410.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000009410.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000009410.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000009410.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase.
CC {ECO:0000256|PIRNR:PIRNR037755}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC {ECO:0000256|ARBA:ARBA00009725, ECO:0000256|PIRNR:PIRNR037755}.
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DR STRING; 31033.ENSTRUP00000082948; -.
DR Ensembl; ENSTRUT00000009465.3; ENSTRUP00000009410.3; ENSTRUG00000003971.3.
DR Ensembl; ENSTRUT00000073478.1; ENSTRUP00000082948.1; ENSTRUG00000003971.3.
DR Ensembl; ENSTRUT00000075471.1; ENSTRUP00000065051.1; ENSTRUG00000003971.3.
DR Ensembl; ENSTRUT00000085052.1; ENSTRUP00000083812.1; ENSTRUG00000003971.3.
DR eggNOG; KOG2361; Eukaryota.
DR GeneTree; ENSGT00940000156679; -.
DR HOGENOM; CLU_029724_2_2_1; -.
DR TreeFam; TF321001; -.
DR Proteomes; UP000005226; Chromosome 7.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProt.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR026113; METTL2/6/8-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22809:SF5; TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR PIRSF; PIRSF037755; Mettl2_prd; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR037755};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037755};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 116..216
FT /note="Methyltransferase type 12"
FT /evidence="ECO:0000259|Pfam:PF08242"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 320 AA; 36777 MW; D3669D37C441C42A CRC64;
MAVSKTESFH DNDEIKHPKE CADLRNKESE SISSVLGQDT KATNRVLTQE EMDKLDGEVL
VSDFKQIKLE KEAQKNWDLF YKRNSTNFFK DRHWTTREFE ELKACREFAS QQLVLLEAGC
GVGNCIFPLL DDELNIFVYA CDFSPRAVEF VKKNPLYSPE RCCAFQCDLT KDDLRENVPE
GSVDVITLIF VLSAVHPDKM KLVLQNISRV LKPGGIALFR DYGLHDHAML RFKSGSKLGE
NFYVRQDGTR SYFFSKDFLA ELFEEVGLQP VTNDYVLRET VNKKEGLCVP RVFLQSKFTK
PSQSQTLRGF EASIMRDTED
//