ID H2SFH6_TAKRU Unreviewed; 877 AA.
AC H2SFH6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Pyruvate dehydrogenase phosphatase regulatory subunit {ECO:0000313|Ensembl:ENSTRUP00000011157.3};
GN Name=PDPR {ECO:0000313|Ensembl:ENSTRUP00000011157.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000011157.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000011157.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000011157.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR AlphaFoldDB; H2SFH6; -.
DR STRING; 31033.ENSTRUP00000066460; -.
DR Ensembl; ENSTRUT00000011217.3; ENSTRUP00000011157.3; ENSTRUG00000004703.3.
DR eggNOG; KOG2844; Eukaryota.
DR GeneTree; ENSGT00940000159082; -.
DR TreeFam; TF314735; -.
DR Proteomes; UP000005226; Chromosome 13.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR13847:SF193; PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 41..399
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 403..457
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 459..735
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 762..855
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 877 AA; 98347 MW; 1C241357C815FA67 CRC64;
VGIAGLLSSG FRLADRGLRT SSRCLTSSGD SQPLPLPGQA RVVICGGGIV GTSVAYHLAK
LGWTDIVLLE QGRLGAGTTR MCAGIVTVAK PLSIECQMAN YSNSLYEQLE EETGVKTGYV
KTGSLCLAQN QDRFLSLKRL ASRLKVMGIS CSIIKPKDVA KLHPFLNIHD LVGALHLPED
AVVSPSDVNH ALAVAAAGRG VQILERTSVQ QVLVEKGQVM AVETDRGSIE CEYFVNCAGQ
WGYELGQASE MKVSVPLHGC EHFYLITKPF QEPLSPNTPV VIDMDGRIYV RPWQGGLLSG
GFEKNPKPIF TEGRNQLEIQ NMQEDWDHFE PMLSSLLRRM PALESAEIQQ LVNCPESFTP
DMRCLMGETP GVSGYYVLAG MNSSGLAFAG GASKYLAEWM TYGYPTANVW PLDIKRFGNL
QSSRTFLRHR VMEVVPLLYE LKVPRWDFQT GRQLRTSPLY DRLDTQGARW MEKHGFERPK
YFVPPGKDLL ALDQSKTFYK PDWFDIVGAE VKCCKEAVCV IDMSSFTKFE LTATGNQALE
LLQHLCANDL DVPVGHIVHT GMLNQRGGYE NDCSVVRLSK NNFFIVSPTD QQVHCWSWMK
KYMPNDPHLH LEDVSWKYTA LNLIGPRAMD VLAELSYVSM TPDHFPSMFC KEMSVGYANG
IRVMSMTHTG EPGFMLYIPI EYALHVYNEV MSVGQKYGIR NAGYYALRSL RIEKFFAFWG
QDLDPFTTPL ECGREFRVKF DKDTDFLGRD ALLQQRQDGV SRRFVMLVLD DHDTELDLWP
WWGEPIYCNG QLAGTTTSSA YSYTLERHVC LGYVSPPTGP DGLPTPITPD FINRGDYEVD
IAGQRYPAKA KLYPFSTLLS QQKRRKEDME LSNLHRE
//
