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Database: UniProt
Entry: H2SIU7_TAKRU
LinkDB: H2SIU7_TAKRU
Original site: H2SIU7_TAKRU 
ID   H2SIU7_TAKRU            Unreviewed;       841 AA.
AC   H2SIU7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   30-AUG-2017, entry version 28.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC101064814 {ECO:0000313|Ensembl:ENSTRUP00000012329};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000012329, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000012329}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000012329}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000012329}.
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DR   STRING; 31033.ENSTRUP00000012329; -.
DR   Ensembl; ENSTRUT00000012389; ENSTRUP00000012329; ENSTRUG00000005146.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; H2SIU7; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    408    432       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    452    471       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    551    572       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    602       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    643    663       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    775    797       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   841 AA;  95687 MW;  016690A256706D12 CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGMVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIKKANIPTV DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
     NFLELTELKH ILRRTQQFFD ESDIHIRQME DPNLLEESSA LMEGNEAGRG APLRLGFVAG
     VISRERIPTF ERMLWRVCRG NVFLRKAEIE DPLEDPTTGD QVHKSVFIIF FQGDQLKNRV
     KKICEGFRAS LYPCPETPQE RKEMLAGVNS RIDDLQMVLN QTEDHRQRVL QAASKTMRVW
     FIKVRKMKAI YHTLNLCNID VTQKCLIAEV WCPVSDLDSI QFALRRGTER SGSTVPSILN
     RMQTKQTPPT FNKTNKFTSG FQNIVDAYGI GSYREINPAP YTIITFPFLF AVMFGDMGHG
     LLMTCGALYL VIRESRLLAQ KSDNEMFNMV FAGRYIILLM GIFSVYTGII YNDCFSKSLN
     MFGSGWSVRP MFGPKGANWT FETLDGNAVL QLDPAIPGVF NGPYPLGIDP IWNVATNKLT
     FLNSFKMKMS VILGVIHMLF GVSLSLFNHL YFKKPLNIFL GFIPEIVFMA SLFGYLVLLV
     FYKWTSYNAY SSKDAPSLLI HFINMCLFNY NDPTNKALYP GQMGIQILLV LIALACVPCM
     LIVKTMMLHR QNLWKKHLGT QKFGGVRVGN GPTEDEAGIM DHDQLSQHSE EGEEFNFGDV
     AVHQAIHTIE YCLGCISNTA SYLRLWALSL AHAQLSEVLW SMVMHLGLSS RSGGGFFGLS
     IIFSAFAGLT VAILLIMEGL SAFLHALRLH WVEFQNKFYA GQGFKFIPFS FESILEGRFD
     E
//
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