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Database: UniProt
Entry: H2SIZ2_TAKRU
LinkDB: H2SIZ2_TAKRU
Original site: H2SIZ2_TAKRU 
ID   H2SIZ2_TAKRU            Unreviewed;       850 AA.
AC   H2SIZ2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   20-DEC-2017, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC101071950 {ECO:0000313|Ensembl:ENSTRUP00000012374};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000012374, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000012374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000012374}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000012374}.
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DR   STRING; 31033.ENSTRUP00000012374; -.
DR   Ensembl; ENSTRUT00000012434; ENSTRUP00000012374; ENSTRUG00000005162.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; H2SIZ2; -.
DR   OMA; GPQYEEF; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    409    433       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    472       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    570       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    577    601       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    660       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    780    803       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
FT   COILED      266    286       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   850 AA;  96989 MW;  8A3BCB5435C58E78 CRC64;
     TKMVFRSEEM CLAQLFLQSG SEYDCISELG ELGLVEFRDL NPSVSSFQRR FVSEIKRCEE
     MERILGYLLR EIQKANIAVP EEDESPLAPP PRQVLEIMEQ LQRLEMELSE VTRNKDKLQR
     NLLELKEYTH MLKITRTFIH SRSRHEALGP QYEEFPTMET DSVTGCTGMQ RLGAKLGFVS
     GLIQRVKMEA FERMLWRVCK GYTILSYAEV DENLADLETG EMSKSVVFLI SFWGDQIGQK
     VQKICDCYHC HLYPHPENDE ERADVLDNLK TRIQDLNNVL HRTEDYLRQV LQKASEAAYS
     WVVQVKKMKA IYHILNLCSF DVTNKCLIAE VWCPVSDLAN LRGALEEGSR KGDATVPSFV
     NRIPCTDTPP TLLRTNKFTS GFQSIVEAYG VGDYREVSPA PYTIITFPFL FAVMFGDLGH
     GIVMSLFALW MVLTEKKQKK KRSSNEIWAT FFSGRYIILM MGLFSIYTGL IYNDCFSKSL
     NMFGSGWSVK AMFANQQWTN KTLRSNALLT LDPNVSGVFS GPYPFGIDPI WNMAVNRLSF
     LNSYKMKMSV IIGVIHMSFG VVLSIFNYLH FRQKFNVYLL FLPELLFLLC LFGYLIFMIV
     YKWLAYGARD SSQAPSILIH FINMFVMQGK DIAPLYPGQT GLQIFLVFIA LLSVPVLLLG
     KPLYLYWTYR GGKACAAASP QGYERVRRAS EDDNSTAPSY DDDEEEGLDE TTRREAVPKQ
     FDLADVLLYQ TIHTIEYCLG CISNTASYLR LWALSLAHAQ LSEVLWAMVM RSGLRITARV
     GVVFLVPVFA VFAVLTVSIL LVMEGLSAFL HALRLHWVEF QNKFYHGAGV KFVPFDFSLL
     PSVFEQEGLI
//
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