ID H2SJG4_TAKRU Unreviewed; 393 AA.
AC H2SJG4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Mitoferrin-2-like {ECO:0000313|Ensembl:ENSTRUP00000012547.2};
GN Name=LOC101072411 {ECO:0000313|Ensembl:ENSTRUP00000012547.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000012547.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000012547.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000012547.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mitochondrial iron transporter that mediates iron uptake.
CC Probably required for heme synthesis of hemoproteins and Fe-S cluster
CC assembly in non-erythroid cells. {ECO:0000256|ARBA:ARBA00037402}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Fe(2+)(in) = Fe(2+)(out); Xref=Rhea:RHEA:28486,
CC ChEBI:CHEBI:29033; Evidence={ECO:0000256|ARBA:ARBA00036243};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR RefSeq; XP_003972240.1; XM_003972191.2.
DR AlphaFoldDB; H2SJG4; -.
DR STRING; 31033.ENSTRUP00000012547; -.
DR Ensembl; ENSTRUT00000012607.3; ENSTRUP00000012547.2; ENSTRUG00000005224.3.
DR GeneID; 101072411; -.
DR KEGG; tru:101072411; -.
DR GeneTree; ENSGT00940000157049; -.
DR InParanoid; H2SJG4; -.
DR OMA; AYECSKE; -.
DR OrthoDB; 5481380at2759; -.
DR Proteomes; UP000005226; Chromosome 17.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006826; P:iron ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45758; MITOFERRIN-1-RELATED; 1.
DR PANTHER; PTHR45758:SF20; MITOFERRIN-2; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00022496};
KW Iron {ECO:0000256|ARBA:ARBA00022496};
KW Iron transport {ECO:0000256|ARBA:ARBA00022496};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 87..175
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 185..269
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 276..377
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 393 AA; 43136 MW; 4C8E0BC870ED7D9D CRC64;
MEANGFVPRR TPLETPGVDS RVTSAAAGAE FRWLGDRAME AMGEFSRSVP PRIAGAQDVG
PVLHRASPDN SSPVEPEIDY EGLPQGVATS THMLAGAVAG IMEHCLMYPI DCVKTRMQSL
HPQPGAHYRN VTDALMQIIR TEGVWRPIRG VNVLAVGAGP AHALYFTCYE KIKFSLSDAI
HPGANSHFAN GVAGCMATLL HDAIMNPAEV VKQRLQMFNS PYRGVLHCMG SLFRQEGLAA
FYRSYTTQLT MNVPFQALHF MTYEYLQELL NPHRQYNPSS HMLSGALAGA VAAAATTPLD
VCKTLLNTQE AQTIHVMQTG VASASAGRHI SGLGEAFRAV YRMGGIPAFF KGVQARVIYQ
MPSTAISWSV YEFFKYILTK RQHDRRLHRD ADK
//
