ID   H2SJM6_TAKRU            Unreviewed;       539 AA.
AC   H2SJM6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Metal response element binding transcription factor 2 {ECO:0000313|Ensembl:ENSTRUP00000012609.3};
GN   Name=mtf2 {ECO:0000313|Ensembl:ENSTRUP00000012609.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000012609.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000012609.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000012609.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the Polycomblike family.
CC       {ECO:0000256|ARBA:ARBA00008084}.
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DR   AlphaFoldDB; H2SJM6; -.
DR   Ensembl; ENSTRUT00000012670.3; ENSTRUP00000012609.3; ENSTRUG00000005257.3.
DR   GeneTree; ENSGT00950000183180; -.
DR   HOGENOM; CLU_032773_1_0_1; -.
DR   Proteomes; UP000005226; Chromosome 22.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035064; F:methylated histone binding; IEA:UniProt.
DR   CDD; cd15578; PHD1_MTF2; 1.
DR   CDD; cd20450; Tudor_MTF2; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 3.90.980.20; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR040477; KDM4-like_Tudor.
DR   InterPro; IPR025894; Mtf2_C_dom.
DR   InterPro; IPR042014; MTF2_PHD1.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12628:SF12; METAL-RESPONSE ELEMENT-BINDING TRANSCRIPTION FACTOR 2; 1.
DR   PANTHER; PTHR12628; POLYCOMB-LIKE TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF14061; Mtf2_C; 1.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF18104; Tudor_2; 1.
DR   SMART; SM00249; PHD; 2.
DR   SMART; SM00333; TUDOR; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00146}.
FT   DOMAIN          66..121
FT                   /note="PHD-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50016"
FT   REGION          353..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          424..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   539 AA;  61040 MW;  548027291ADE8B5C CRC64;
     MSDKFTEGQD VLARWSDGLF YLGTITKIDR DKHRCFVVFE DRSKSWVLWK DIQTGDEDDE
     DDEDDDLVCS ICQDETSEEP NEIVICDKCG QGYHQLCHSP IIDASVIDCD DNWLCYECEL
     TSLPKGGGVQ RREGSAKGFL KQEQPVDVHL SLPYALDELI WDQGHITNLQ QCYCYCGGPG
     DWYLKMLQCN RCEQWFHEAC LHCLQMPLLY GDRFYLFICS VCNTGPEYIR RLTLSWVDVT
     HLSLYNLSVI HKKKYFDSEM HLMTYINDNW ELLQLGELTN TPSSERYKNV LEALNNNSNT
     FMSGKEVKKK KHLFGLRIRL PPAPPNSSEP ASKLMERSLH EITIKGCKPT KTTLSGSKTC
     NNLTNGTDKK KKKKKKKRKP GPRSLEALAK RQRSAEVLTQ VNNQLFHFLV PASISLCSSS
     KTHTTASIMP ISSPPLKRKR GRPRRNLQSP NPGIPPPSHA DPIPTTTEVL SPLTGLNSTD
     IVHSMDPNSQ LSHLKNSISN YFGAAGRLAC GEKYKVLARR VTLDGKVQYL VEWEGVTAS
//