ID H2SKE3_TAKRU Unreviewed; 573 AA.
AC H2SKE3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Synaptotagmin binding cytoplasmic RNA interacting protein {ECO:0000313|Ensembl:ENSTRUP00000012876.3};
GN Name=syncrip {ECO:0000313|Ensembl:ENSTRUP00000012876.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000012876.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000012876.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000012876.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; H2SKE3; -.
DR Ensembl; ENSTRUT00000012937.3; ENSTRUP00000012876.3; ENSTRUG00000005365.3.
DR eggNOG; KOG0117; Eukaryota.
DR GeneTree; ENSGT00940000153511; -.
DR TreeFam; TF314932; -.
DR Proteomes; UP000005226; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21066; NURR_hnRNPQ; 1.
DR CDD; cd12483; RRM1_hnRNPQ; 1.
DR CDD; cd12495; RRM3_hnRNPQ; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR041337; hnRNP_Q_AcD.
DR InterPro; IPR006535; HnRNP_R/Q_splicing_fac.
DR InterPro; IPR034544; hnRNPQ_RRM1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01648; hnRNP-R-Q; 1.
DR PANTHER; PTHR21245; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; 1.
DR PANTHER; PTHR21245:SF11; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN Q; 1.
DR Pfam; PF18360; hnRNP_Q_AcD; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 162..241
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 243..325
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 338..408
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 64265 MW; EDF4561E2089C263 CRC64;
MATEHINGNG PEDPMDTSAA VTHSEHFQTL LEAGLPQKVA EKLDEIYIAG LVSHSDLDDR
AIEALKEFNE EGALQVLLQF KDSDLSHVQN KSAFLCGVMK TYRQREKQGT KVSDTSKGPD
EAKIKALLER TGYTLDVTTG QRKYGGPPPE AVHSGAQPTI GTEIFVGKIP RDLFEDELVP
LFEKAGPIWD LRLMMDPLSG LNRGYAFVTF CTKEAAQQAV KLCNNNEIRP GKHIGVCISV
ANNRLFVGSI PKSKTKEQII EEFSKVTEGL NDVILYLQPV DKKKNRGFCF LEYEDHKTAA
QARRRLMSGK VKVWGNLVTV EWADPLEDPD PEVMAKVKVL FVRNLASSVT EELLEKAFSQ
FGKLERVKKL KDYAFIHFEE RDGAVKALAD LNGKDLEGEH IEIVFAKPPD QKRKERKAQR
QAAKTHMYDE YYYYGPPHMP PPSRGRGRGA RGGYAYPPDY YGYEDYYSYY GYDYHNYRGG
YDDPYYVYDD FQGTGRGRGR GGLRGAASQN KGRGAAPPRG RLGFSQRGPG TSSRGKSKQL
QCKNNVLNSN WACKTISCDE SEQALPLSYF ELN
//
