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Database: UniProt
Entry: H2SL27_TAKRU
LinkDB: H2SL27_TAKRU
Original site: H2SL27_TAKRU 
ID   H2SL27_TAKRU            Unreviewed;      4880 AA.
AC   H2SL27;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSTRUP00000013112};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000013112, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000013112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000013112}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000013112}.
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DR   Ensembl; ENSTRUT00000013173; ENSTRUP00000013112; ENSTRUG00000005462.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 3.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4188   4211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4413   4433       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4484   4505       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4680   4702       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4723   4741       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4761   4784       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    215       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      223    278       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      284    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      349    407       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      597    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1209       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1255   1470       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3951   3986       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4880 AA;  550986 MW;  E3328EB2A5DA2D0B CRC64;
     MSHSGEADEE FQFLRTGDEV VLQSTFTSQG EHVKICLAAE GFGTRLCRLE PVSNCKNVPP
     DMSVCGFILA NCLSVRALHE MLSHTEHLAA ETQLSAGGSH RTLLYGQAVL FLHSDSSMYL
     SCLSSSRSST DKLAFDVGLR EEKGGETCWW IVHPSSRQRS EGEKVRVGDD LILVNMSSER
     YLHLSAGSGF DSRSVIDSLS VNASFQQTLW SVAPIYCGGG VAQGYLKGGD TFWLHHSHSD
     ACLTIPSTEQ GEEPQKVMHY ETESVSCHAR SLWRLETLHV VWSGSHTYWG QPFRLCHVTT
     GRYMGLTEEK GLHLVDRDKA DVKTTSFCFR SSKEKLDSCV KTNIDGMGSP AIKYGDSVCY
     VQHVDSGLWL TYQSVDAKSS RIGTTQKKRA ILHSEGHMDD GLTLSRCQRE ESHTARLIRS
     ASLLFTHFVS HGNHTSVGLT RELLGHSLQD LINYFQPTVE TLDHEATQHT MVVLKNRQNM
     FQEEGVIDLV LDCIDHLHQH IGASQWDSEE EVETSLNGFY KLLAVLLRGN RVNCAHFSTS
     IDWLISRLDW LEASTGVLEV LQCVLLESPE AINAIKEIHI HSVISFLEKH GFNHKVLEVL
     CSLCVCHGVA VRYNQNLICD KLLPDRDLLL QTRLINQVTS MRPNIFLFLG DDSAQHRRWY
     YEVVVDDLDP FVTSEPTHLR VGWASTEGYR PRPSGGEGWG GNGVGDDLCS YGFDGLHLWS
     GGVGRRVSSP FPHSLKDGDV VSCCLDLSAP CISFRVNGLP VQGMLENFVA EGLLHPVVSF
     SAGVKIRFLF GGQHGEFRFL PPPGFTPCSD ALLPKVKLTV EACQTHILNH GEGQHDLFGP
     LIPSTPVVFI PAPVDISKVP LPPQLEDIRE KMAENIHQLW AMDKIDLGWT FGPVRDEVKK
     NDPGLVEFSK LSEPERNQNL HIAQDTLRTL LAFGFRIGFN EDHSEDRVKY ISLAAKYEQP
     SGYRPAPVDL SQVRLSSDHE EVVRLLAEND HNIWARERIK QGWTYGTQQD VKAKRSPCLV
     PYSFLDQRTR KVGRDRVREV VGTLLALGYS LETHNQKQAS LSNPCLFSAE KYRVFRPDKS
     HTVSTGKWYF EFEAVTAGKM RVGWTRPSCT PDRELGSDDQ AFVFDGFEAQ WYHQGADPLG
     RPWQKGDVVG CLVDMDECTM MITLNGELLF DGRGSELAAK DFEISDGLLP VVSVGVNQVG
     RLNFGRCVAS LQYFTVYGQQ EGYHPFAANM ARDPALWISW QQPQFSSIMP DHPNVQVTRV
     NGSVESLSSL RVSQRLCAHH NGGSEISFFR LSMHIECASV LVSPVGGVLP IASNSLSPGR
     KELEEIQSHN NVQYYYSVRV LPGQEPFNVW VGWVTSNFHQ HEATFDPDNV HTVTVTLGDE
     SGKVRESVKR SVCYMVCAGE ATGLSQSRRS SGLEISCLID TDTGLLTFTS NGVEMSTFFQ
     VEACTKLFPA VFVRPTTNSM FQFEFGCIKN AMPLSAGLLR SQRCNTAPHC PPRIQVQQLK
     PVSWTRLPSQ AVKVNVDQPD VYRGWRIQCS EALQAMNLQI PDENRSFDIL ELSELEDLLT
     FHHHTLRLYC SLCSLGNSRV SHAICSYMDQ SQILHAIQNP HLPGLLRSVF YELLIQVHLS
     SHTTAYLMMN HEYIVPMTAK ARDITLYPSS FTGDNGGTGI SNFSHGTSLK PQMHSSSPSF
     VQIYEGNYAA EIAQEDSPEF PLDVLKNLTV QMLTEAVDVL RQNLRDPVGG NIELLLVPLL
     KLVYSLLVMG VLEDEDLGKV LRLLDSGVFF TNPQSPKDKE KEVECDDEKE YSDSQQQKEY
     DHKVGLLQMK LPEPVKLELC RLLSYLCDCQ MRQRVEAVAA FSDSFVVQLQ ENQRFRYNEV
     MQALNMSAAL TARKTKEFRS PPWEQINMLL RFRDDGVSCP CPVEIQELLQ EFHHLLKTHC
     GIESESDGEG EEVAEASVKN LLLSQVAKVI GLKIKPFEVA ESKAVNTKTL KDLISKTMVH
     WSQEAKMQDP ELVRAVFSLL HCQYQGLGGQ MAGPLSRTYS ISLTSVDDTM ALLSSLSQIR
     SLLCVCMGKE EEKLMIRKLG DIINNKVFYQ HPDLMRTLGM HETVMEVMVN VLGEGESKEI
     TFPKMVASCC RFLCYFCRIS RHNQGALFDH LSYLLENSSV GLASPSMRGA TPLDVAAASV
     MDNNELALAL TESDLQKVIQ YLASCGLKSC PMLLAKGYPD IGWNPVEGER YLDFLRFAVF
     CNGESVEENA YMVLRLLIRR PECFGPALQG DGGTGLLAAM REAIRISDDP SIDRSSCPHQ
     ANRTIFHQDN GDDLIHMGHA ILTFYSALID LLGRCAPEMH LIQGGRGDAL RIRAILRSLV
     PVHDLEGVIS SSFCVPSASK DGCGIVEPNL STVFCPDHKA AMVLFLDRVY GIEKQSFLLH
     LIEVGFLPDL QAAVSLDTVE LASTDMALAL NRYLCASVLP LLTKYSALFC HLEDHILLVD
     SLIQAIYSLS NALSLTKAQR DTIEDCLLAL CSKLQPSLMQ PLLRRLVFDV LHLTEYNKLA
     LKLLTSHYEQ RSQYYLMVGE LSHHSLASEE ELHLSQKLYW RVFKAVNKKP YEPQLFRLCV
     QCLAAVANAL PPDHSDTGYQ SQAEGKASAD TDGQFDPQPI DTSNVSVPER LEFIVNKYAE
     HTHEKWSLDK FANGWVHGEQ LCENSKIHPL LKPYRALAEK EKEAYRCAIK ETIKSMLAFG
     WTIERTKEGE ARDVHTCTRR VSQSGQQGAS TFSPKATDMS AITLSWDQCT MAEQLAENYH
     SSWAKRRKLD YETRGGGGHS MIVPYDTLTA KEKTKFRERA QDILKFLHLN GYTVWRDRRT
     VEVDFPAVAN CFGSTLLKQF LSHTENAQEH MLELEVMQAR GQMYKGERAP QHQPILFFYK
     VILPLLEEYM RTHRLYFLSS SMSSRGKRGH ASNKEKEMIA SLFCKIAELI RHRLPLFGND
     ASTLSNCLCA LAQALDARTL MKSAPESVHS SLNSFFETSA ADLEMTVENL SMNMACLPQI
     RNQHARGAAR VLSHTSSVLL PMLTSLFQHL GLQNYGGDLL VGSIQVSCYR ILNSLYTLGT
     TSSLYMEEQR PAAGACLAAL TGTFPVCFLE PALNQNNPYS IYNTICALER EELGLPDHVE
     DVCPLLPSLE QALRDVKQLA GAGAGARQTQ YIHVTEVILP MLCSYMSFWW SWGPEGHPDS
     PMCTSVTPHH ASDLLGHVLR IIHNHVGTSQ GDWMKQMAVH CLSIICHGHS ELLKTHFLPL
     MGKLKKRAES VLLEEERMKT EGGDTSEAEL EIQQKFMVLV ADLYAFYPLL IPFVDSNRVH
     WWKESNPEAE QLFLMVSEVF IFWAKSHNFK WEEQNYVVQN EINSLLFLVN SDSLSKVVTS
     AMPVHYKNYF HEKRKMKKKG DRYSTHTSLI VASLKRLLPV GLRNCLLSDQ SLITLAKNGF
     AQKNPEDEIR KRIFSNFTQL QSQANNSQPN YPVHVFKFQY KRGTIPDVQT TVEKILNMGR
     VLCYLDQVEH PQRSRKPTRH KILSKQRKRA VVACLRMAPL YNLPRHRAVN LFLQGYNKTW
     ISTEDHNFEE KLVEDLAVSA KVSGREEDDR GDGAKAIDPL LQLITLFGQT ALMDRRQLEN
     GHLYQSYAAI MAKSCHREDD GDSKEQELES FEEFQEKELE KQKLLFQQAR LHHRGASEMV
     LQIISASRGF MGSVIAPTLK LGIALLSGGN AAVQQKMLVY LIERRDLGFF QSTAALMLSC
     SVLDLNAFER QNKAEGLGMA MDESSGTAFI WKSKNKVMPD KDVICDLFRF LQLLCEGHNS
     DFQNYLRTQT GNNTTVNIII STVDYLLRLQ ESISDFYWYY SGKGVIDVHG QHNFFKAIGV
     SKQVFNTLTE YIQGPCAGNQ ESLAHSRLWD AVVGFLHVFA HMQMKLPQDS RQMDLLIELL
     DLQKDMVVFL LSMLEGNVVN GTIGKQMVDM LVESSGNVQM ILKFFDMFLK LKDFTSSDVF
     RAYDPDFKGC ISRKDFEKAM KSCKRFSHTE TRFLISCMET DDSEAVDYVA FVNRFNEPAQ
     DIGFSIAVLL TNLSEHMPND ARLRTFLEVA ESILTYFQPF LGRIEILGSG KRMERVYFRI
     SESSRTQWEK PQVKESKRQF IFDVVNESGD KEKMEMFVNF CEDTIFEMQL AAQLSGSGNE
     ERRVETRPET EDGLDSKGIS VIYQWPLLIS ALSVRHVKTL MKMTLKDIFI SAIFLLRFVF
     MAQIRCICIG IRSILYVLYR AFLSGELIEG AKKVRILEML GGILEPTLDE VTGGPSGDQL
     RKYSCSLTLQ EETSGIRQAE GVTSTRDMDG LSNVFGLKVK KEGSCYRLIA KDLTDSLTDL
     FTTTSGRVKA AEVPEKHQET THIYKEEQTE EKGTDRKGID IEKKSEVIMM EPKWRAKSHP
     QKSEEPENQQ SALWGIISTH NKSMLNYFAR NYYNMRVLAL FVTFAINFIL LFYKVASSPT
     AHVEGKETTP PSRQESYSAG DEDEEDGTVY FVLEESSGYM ESSLHFLAVV HTIISFFCII
     GYYCLKVPLV IFKREKEVAR KLEFDGLYVT KQPPEEDIKG QWDRLVVHTP SFPSNYWDKF
     VKRKVMDKYG ELYGCEKISN LLGLDQAALD CSSERKGRKR LRKNTAWSHV FSSVDMKYQL
     WKTGVVFTDN SFLYLAWYMI LSGLGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL
     VLTVGLLAVV VYLYTVLAFN FFRKFYNKSE DEDTQDMKCN DMFTCYMFHM YVGVRAGGGI
     GDEIEDPAGD EFEVERIVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVKEDMETK
     CFICGIGNEY FDKVPHGFET HTLQEHNLAN YLFFLMYLIN KDETEYTGQE SYVWKMYQER
     SWEFFPVGDC FRKQYEDQLG
//
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