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Database: UniProt
Entry: H2SL29_TAKRU
LinkDB: H2SL29_TAKRU
Original site: H2SL29_TAKRU 
ID   H2SL29_TAKRU            Unreviewed;      4877 AA.
AC   H2SL29;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   22-NOV-2017, entry version 37.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSTRUP00000013114};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000013114, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000013114}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000013114}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000013114}.
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DR   Ensembl; ENSTRUT00000013175; ENSTRUP00000013114; ENSTRUG00000005462.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 4.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4196   4219       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4410   4430       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4481   4502       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4677   4699       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4720   4738       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4758   4781       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    215       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      223    278       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      284    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      349    407       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      603    801       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1018   1215       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1261   1475       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3959   3994       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4877 AA;  550671 MW;  7C198B7B4E1569DE CRC64;
     MSHSGEADEE FQFLRTGDEV VLQSTFTSQG EHVKICLAAE GFGTRLCRLE PVSNCKNVPP
     DMSVCGFILA NCLSVRALHE MLSHTEHLAA ETQLSAGGSH RTLLYGQAVL FLHSDSSMYL
     SCLSSSRSST DKLAFDVGLR EEKGGETCWW IVHPSSRQRS EGEKVRVGDD LILVNMSSER
     YLHLSAGSGF DSRSVIDSLS VNASFQQTLW SVAPIYCGGG VAQGYLKGGD TFWLHHSHSD
     ACLTIPSTEQ GEEPQKVMHY ETESVSCHAR SLWRLETLHV VWSGSHTYWG QPFRLCHVTT
     GRYMGLTEEK GLHLVDRDKA DVKTTSFCFR SSKEKLDSCV KTNIDGMGSP AIKYGDSVCY
     VQHVDSGLWL TYQSVDAKSS RIGTTQKKRA ILHSEGHMDD GLTLSRCQRE ESHTARLIRS
     ASLLFTHFVR KLDNCTHGNH TSVGLTRELL GHSLQDLINY FQPTVETLDH EATQHTMVVL
     KNRQNMFQEE GVIDLVLDCI DHLHQHIGAS QWDSEEEVET SLNGFYKLLA VLLRGNRVNC
     AHFSTSIDWL ISRLDWLEAS TGVLEVLQCV LLESPEAINA IKEIHIHSVI SFLEKHGFNH
     KVLEVLCSLC VCHGVAVRYN QNLICDKLLP DRDLLLQTRL INQVTSMRPN IFLFLGDDSA
     QHRRWYYEVV VDDLDPFVTS EPTHLRVGWA STEGYRPRPS GGEGWGGNGV GDDLCSYGFD
     GLHLWSGGVG RRVSSPFPHS LKDGDVVSCC LDLSAPCISF RVNGLPVQGM LENFVAEGLL
     HPVVSFSAGV KIRFLFGGQH GEFRFLPPPG FTPCSDALLP KVKLTVEACQ THILNHGEGQ
     HDLFGPLIPS TPVVFIPAPV DISKVPLPPQ LEDIREKMAE NIHQLWAMDK IDLGWTFGPV
     RDEVKKNDPG LVEFSKLSEP ERNQNLHIAQ DTLRTLLAFG FRIGFNEDHS EDRVKYISLA
     AKYEQPSGYR PAPVDLSQVR LSSDHEEVVR LLAENDHNIW ARERIKQGWT YGTQQDVKAK
     RSPCLVPYSF LDQRTRKVGR DRVREVVGTL LALGYSLETH NQKQASLSNP CLFSAEKYRV
     FRPDKSHTVS TGKWYFEFEA VTAGKMRVGW TRPSCTPDRE LGSDDQAFVF DGFEAQWYHQ
     GADPLGRPWQ KGDVVGCLVD MDECTMMITL NGELLFDGRG SELAAKDFEI SDGLLPVVSV
     GVNQVGRLNF GRCVASLQYF TVYGQQEGYH PFAANMARDP ALWISWQQPQ FSSIMPDHPN
     VQVTRVNGSV ESLSSLRVSQ RLCAHHNGGS EISFFRLSMH IECASVLVSP VGGVLPIASN
     SLSPGRKELE EVDSDFEVYY YSVRVLPGQE PFNVWVGWVT SNFHQHEATF DPDNVHTVTV
     TLGDESGKVR ESVKRSVCYM VCAGEATGLS QSRRSSGLEI SCLIDTDTGL LTFTSNGVEM
     STFFQVEACT KLFPAVFVRP TTNSMFQFEF GCIKNAMPLS AGLLRSQRCN TAPHCPPRIQ
     VQQLKPVSWT RLPSQAVKVN VDQPDVYRGW RIQCSEALQA MNLQIPDENR SFDILELSEL
     EDLLTFHHHT LRLYCSLCSL GNSRVSHAIC SYMDQSQILH AIQNPHLPGL LRSVFYELLI
     QVHLSSHTTA YLMMNHEYIV PMTAKARDIT LYPSSFTGDN GGTGISNFSH GTSLKPQMHS
     SSPSFVQIYE GNYAAEIAQE DSPEFPLDVL KNLTVQMLTE AVDVLRQNLR DPVGGNIELL
     LVPLLKLVYS LLVMGVLEDE DLGKVLRLLD SGVFFTNPQS PKDKEKEVEC DDEKEYSDSQ
     QQKEYDHKVG LLQMKLPEPV KLELCRLLSY LCDCQMRQRV EAVAAFSDSF VVQLQENQRF
     RYNEVMQALN MSAALTARKT KEFRSPPWEQ INMLLRFRDD GVSCPCPVEI QELLQEFHHL
     LKTHCGIESE SDGEGEEVAE ASVKNLLLSQ VAKVIGLKIK PFEVAESKAV NTKTLKDLIS
     KTMVHWSQEA KMQDPELVRA VFSLLHCQYQ GLGGQMAGPL SRTYSISLTS VDDTMALLSS
     LSQIRSLLCV CMGKEEEKLM IRKLGDIINN KVFYQHPDLM RTLGMHETVM EVMVNVLGEG
     ESKEITFPKM VASCCRFLCY FCRISRHNQG ALFDHLSYLL ENSSVGLASP SMRGATPLDV
     AAASVMDNNE LALALTESDL QKVIQYLASC GLKSCPMLLA KGYPDIGWNP VEGERYLDFL
     RFAVFCNGES VEENAYMVLR LLIRRPECFG PALQGDGGTG LLAAMREAIR ISDDPSIDRS
     SCPHQANRTI DVVQDNGDDL IHMGHAILTF YSALIDLLGR CAPEMHLIQG GRGDALRIRA
     ILRSLVPVHD LEGVISSSFC VPSASKDGCG IVEPNLSTVF CPDHKAAMVL FLDRVYGIEK
     QSFLLHLIEV GFLPDLQAAV SLDTVELAST DMALALNRYL CASVLPLLTK YSALFCHLED
     HILLVDSLIQ AIYSLSNALS LTKAQRDTIE DCLLALCSKL QPSLMQPLLR RLVFDVLHLT
     EYNKLALKLL TSHYEQRSQY YLMVGELSHH SLASEEELHL SQKLYWRVFK AVNKKPYEPQ
     LFRLCVQCLA AVANALPPDH SDTGYQSQAE GKASADTDGQ FDPQPIDTSN VSVPERLEFI
     VNKYAEHTHE KWSLDKFANG WVHGEQLCEN SKIHPLLKPY RALAEKEKEA YRCAIKETIK
     SMLAFGWTIE RTKEGEARDV HTCTRRVSQS GQQLSFEGAS TFSPKATDMS AITLSWDQCT
     MAEQLAENYH SSWAKRRKLD YETRGGGGHS MIVPYDTLTA KEKTKFRERA QDILKFLHLN
     GYTVWRDRRT VEVDFPAVAN CFGSTLLKQF LSHTENAQEH MLELEVMQAR GQMYKGERAP
     QHQPILFFYK VILPLLEEYM RTHRLYFLSS SMSSRGKRGH ASNKEKEMIA SLFCKIAELI
     RHRLPLFGND ASTLSNCLCA LAQALDARTL MKSAPESVHS SLNSFFETSA ADLEMTVENL
     SMNMACLPQI RNQHARGAAR VLSHTSSVLL PMLTSLFQHL GLQNYGGDLL VGSIQVSCYR
     ILNSLYTLGT TSSLYMEEQR PAAGACLAAL TGTFPVCFLE PALNQNNPYS IYNTICALER
     EELGLPDHVE DVCPLLPSLE QALRDVKQLA GAGAGARQTQ YIHVTEVILP MLCSYMSFWW
     SWGPEGHPDS PMCTSVTPHH ASDLLGHVLR IIHNHVGTSQ GDWMKQMAVH CLSIICHGHS
     ELLKTHFLPL MGKLKKRAES VLLEEERMKT EGGDTSEAEL EIQQKFMVLV ADLYAFYPLL
     IPFVDSNRVH WWKESNPEAE QLFLMVSEVF IFWAKSHNFK WEEQNYVVQN EINSLLFLVN
     SDSLSKVVTS AMPVHYKNYF HEKRKMKKKG DRYSTHTSLI VASLKRLLPV GLRNCLLSDQ
     SLITLAKNGF AQKNPEDEIR KRIFSNFTQL QSQANNSQPN YPVHVFKFQY KRGTIPDVQT
     TVEKILNMGR VLCYLDQVEH PQRSRKPTRH KILSKQRKRA VVACLRMAPL YNLPRHRAVN
     LFLQGYNKTW ISTEDHNFEE KLVEDLAVSA KREEDDRGDG AKAIDPLLQL ITLFGQTALM
     DRRQLENGHL YQSYAAIMAK SCHREDDGDS KEQELESFEE FQEKELEKQK LLFQQARLHH
     RGASEMVLQI ISASRGFMGS VIAPTLKLGI ALLSGGNAAV QQKMLVYLIE RRDLGFFQST
     AALMLSCSVL DLNAFERQNK AEGLGMAMDE SSGTAFIWKS KTDKVMPDKD VICDLFRFLQ
     LLCEGHNSDF QNYLRTQTGN NTTVNIIIST VDYLLRLQES ISDFYWYYSG KGVIDVHGQH
     NFFKAIGVSK QVFNTLTEYI QGPCAGNQES LAHSRLWDAV VGFLHVFAHM QMKLPQDSRQ
     MDLLIELLDL QKDMVVFLLS MLEGNVVNGT IGKQMVDMLV ESSGNVQMIL KFFDMFLKLK
     DFTSSDVFRA YDPDFKGCIS RKDFEKAMKS CKRFSHTETR FLISCMETDD SEAVDYVAFV
     NRFNEPAQDI GFSIAVLLTN LSEHMPNDAR LRTFLEVAES ILTYFQPFLG RIEILGSGKR
     MERVYFRISE SSRTQWEKPQ VKESKRQFIF DVVNESGDKE KMEMFVNFCE DTIFEMQLAA
     QLSGSGNEER RVETRPETED GLDSKGISVI YQWPLLISAL SVRHVKTLMK MTLKDIFISA
     IFLLRFVFMA QIRCICIGIR SILYVLYRAF LSGELIEGAK KVRILEMLGG ILEPTLDEVT
     GGPSGDQEET SGIRQAEGVT STRDMDGLSN VFGLKVKKEG SCYRLIAKDL TDSLTDLFTT
     TSGRVKAAEV PEKHQETTHI YKEEQTEEKG TDRKGIDIEK KSEVIMMEPK WRAKSHPQKS
     EEPENQQSAL WGIISTHNKS MLNYFARNYY NMRVLALFVT FAINFILLFY KVASSPTAHV
     EGKETTPPSR QESYSAGDED EEDGTVYFVL EESSGYMESS LHFLAVVHTI ISFFCIIGYY
     CLKVPLVIFK REKEVARKLE FDGLYVTKQP PEEDIKGQWD RLVVHTPSFP SNYWDKFVKR
     KVMDKYGELY GCEKISNLLG LDQAALDCSS ERKGRKRLRK NTAWSHVFSS VDMKYQLWKT
     GVVFTDNSFL YLAWYMILSG LGHYNNFFFA AHLLDIAMGF KTLRTILSSV THNGKQLVLT
     VGLLAVVVYL YTVLAFNFFR KFYNKSEDED TQDMKCNDMF TCYMFHMYVG VRAGGGIGDE
     IEDPAGDEFE VERIVFDITF FFFVIVILLA IIQGLIIDAF GELRDQQEQV KEDMETKCFI
     CGIGNEYFDK VPHGFETHTL QEHNLANYLF FLMYLINKDE TEYTGQESYV WKMYQERSWE
     FFPVGDCFRK QYEDQLG
//
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