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Database: UniProt
Entry: H2SNA0_TAKRU
LinkDB: H2SNA0_TAKRU
Original site: H2SNA0_TAKRU 
ID   H2SNA0_TAKRU            Unreviewed;      2000 AA.
AC   H2SNA0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 44.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000013886, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000013886}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000013886}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000013886}.
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DR   STRING; 31033.ENSTRUP00000013886; -.
DR   Ensembl; ENSTRUT00000013949; ENSTRUP00000013886; ENSTRUG00000005719.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H2SNA0; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     99    119       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    145       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    196    216       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    228    245       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    391    418       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    736       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    771       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    828    856       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    916    941       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    961    983       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1195   1215       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1235   1253       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1260   1278       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1324   1347       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1434   1457       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1516   1534       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1580   1599       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1647   1669       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1737   1760       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    424       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      520    625       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      718    946       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      955   1190       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1194   1466       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1515   1770       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   2000 AA;  227847 MW;  4429471F1E366D53 CRC64;
     MAAMLLPTGP DGLRRFTRES LAALERRIAE EQAKKAKGCH NTHKYADPLK PRIDLEAGKQ
     LPRIYGDVPP ELIGIPLEDV DPFYYKNQRT FIVLNKGKAL FRFSATSALY IFSPFHFLRA
     IAVRILVHSL FSLFIMFTIL TNCFFMAMSD PAPWTKYLEY TFTAIYTFES VIKIFARGFC
     LVPFSFLRDP WNWLDFTVIV MAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVRKLAD VMILTVFCLS VFALIGLQLF MGLLRQKCVR SLGHCINSSY SSTESFLCNN
     RTWSSQEDFL SSEENFYKIE GAKDALICGY GNDAGKCPDG FDCLKVGRNP NYGYTSFDTF
     GWAFLALFRL MTQDCWEKLF HQTLRSAGKT YMVFFVLVIF LGSFYLVNLI LAVVAMAYEE
     QNQATIAEAW QKEREFQMAM EHLRREQRAA KRQAQETDSV LSPELSPFYL KAGSIRRSSS
     RRRRSHRTLS EETAGEASEE KFDDPDEPIP PLSPLPAHPL LATLSAHPLS TRRGSQVSIF
     SSFRARINSE ADFGDDEYSV HGDAFRSRAS SMATPWKRRT GSVRSHCSQI LNPSLNVNGR
     LNISLDQNAV TTLGLHTPTS IPAPSMERVR EDTVSDTTPI LAPPQQPSPT VTEPPTVHRK
     RGLSSVSFLS DAMDELEESR QKCHPCWYTF AKRYLIWECC PWWRQIKEWV KHMVMDPFLD
     LGITICIVLN TLFMALEHYP MTEEFNTMLS VGNLVFTGIF TAEMVLKLIA LDPYYYFQQG
     WNIFDGVIVC LSLMELGLSN VEGLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG
     NLTLVLAIIV FIFAVVGMQL FGKNYQDCVC KISFDCQLPR WHMKDFFHSF LIVFRVLCGE
     WIETMWDCME VAGQPLCILV FMLVMVIGNL VVLNLFLALL LSSFSSDNLS APDEDGDLNN
     IQIAIARITV GVSWLVSSVT NVFNRRIKHR KPKSQETHQA VKLVVNHVEC NGGIYGEKYV
     IPEEDSYMTN PNLTVIVPIA PGESDVEFLE EEENSDTSDD EDNKEVRGSS PSILQIASAP
     KSSQWYDVVL QQTIQYYVAV WNIFSIKYSV SPSSWKLLST QEKISLSEGS TVDLRKPGEE
     LDNFSELAEE SMEPEECFPE FCVRHCHCCH IDVTRGLGQA WWRLRKTCYQ IVEHSWFETF
     IIFMILLSSG ALAFEDIYIE KRKVIKLVLE AADKVFSYIF VLEMFLKWIA YGFKKYFTNY
     WCWLDFLIVD VSLISLAANS LGYSDFTAIK SLRTLRALRP LRALSRFEGM RVVVNALIGA
     IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF GKCVNRTGFI HSVSVVNNKS DCLAMNDTQF
     YWTKVKVNFD NVGIGYLSLL QVATFKGWME IMHAAVDSRG VEEQPIREIN IYMYLYFVVF
     IIFGSFFTLN LFIGVIIDNF NQQKRKLGGQ DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP
     TNIIQAFFFD LVSKQAFDIM IMMLIIVNMV TMMVETDEQS EHMEAILNKI NHVFIVIFTT
     ECLIKIFALR CYFFTIAWNI FDFVVIILSI VGIVLADLIE KYFVSPTLFR VIRLARIGRV
     LRLIRAAKGI RTLLFALMMS MPALFNIGLL LFLVMFIYAI FGMANFAYVK KQDGIDDMFN
     FETFGNSMIC LFQISTSAGW DNLLSPIMAN SPTECDVNFV NTGTNTRGNC GSPSMGIAFF
     VSYIIISFLI VVNMYIAIIL ENFSVATEES TEPLSEDDFE MFYEVWEKFD SEATQFIEFS
     MLSNFADTLS EPLRIAKPNM IKLISMDLPM VSGDRIHCLD ILFAFTKRVL GESGEMDALK
     QQMEEKFMMT NPSKVSHEPI TSTLRRKVEE VSATIIQRCY RRHLVRRQMK QASHLYRQIN
     QETVVDVENA LETEGLIASM IQHFGPVEVE VLETTADTEL SSPPSYESVT RAGSDLSEVM
     RSISRDTEQE DPGENYEETF
//
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