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Database: UniProt
Entry: H2SNA7_TAKRU
LinkDB: H2SNA7_TAKRU
Original site: H2SNA7_TAKRU 
ID   H2SNA7_TAKRU            Unreviewed;      1703 AA.
AC   H2SNA7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   30-AUG-2017, entry version 37.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000013893, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000013893}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000013893}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000013893}.
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DR   Ensembl; ENSTRUT00000013956; ENSTRUP00000013893; ENSTRUG00000005719.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    103    123       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    129    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    200    220       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    232    249       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    255    278       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    395    422       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    565    583       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    595    618       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    675    703       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    763    788       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    808    830       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    987   1007       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1027   1045       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1052   1070       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1116   1139       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1226   1249       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1308   1326       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1372   1391       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1439   1461       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1529   1552       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      132    428       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      565    793       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      802    982       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      986   1258       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1307   1562       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1703 AA;  194751 MW;  E2A3C9C612AA727D CRC64;
     QDEKMAAMLL PTGPDGLRRF TRESLAALER RIAEEQAKKA KGCHNTHKYA DPLKPRIDLE
     AGKQLPRIYG DVPPELIGIP LEDVDPFYYK NQRTFIVLNK GKALFRFSAT SALYIFSPFH
     FLRAIAVRIL VHSLFSLFIM FTILTNCFFM AMSDPAPWTK YLEYTFTAIY TFESVIKIFA
     RGFCLVPFSF LRDPWNWLDF TVIVMAYVTE FVDLGNVSAL RTFRVLRALK TISVIPGLKT
     IVGALIQSVR KLADVMILTV FCLSVFALIG LQLFMGLLRQ KCVRSLGHCI NSSYSSTESF
     LCNNRTWSSQ EDFLSSEENF YKIEGAKDAL ICGYGNDAGK CPDGFDCLKV GRNPNYGYTS
     FDTFGWAFLA LFRLMTQDCW EKLFHQTLRS AGKTYMVFFV LVIFLGSFYL VNLILAVVAM
     AYEEQNQATI AEAWQKEREF QMAMEHLRRE QRVVVFSANP PSVCLQPPLS PLPAHPLLAT
     LSAHPLSTRR GSQPSPTVTE PPTVHRKRGL SSVSFLSDAM DELEESRQKC HPCWYTFAKR
     YLIWECCPWW RQIKEWVKHM VMDPFLDLGI TICIVLNTLF MALEHYPMTE EFNTMLSVGN
     LVFTGIFTAE MVLKLIALDP YYYFQQGWNI FDGVIVCLSL MELGLSNVEG LSVLRSFRLL
     RVFKLAKSWP TLNTLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK NYQDCVCKIS
     FDCQLPRWHM KDFFHSFLIV FRVLCGEWIE TMWDCMEVAG QPLCILVFML VMVIGNLVVL
     NLFLALLLSS FSSDNLSAPD EDGDLNNIQI AIARITVGVS WLVSSVTNVF NRRIKHRKPK
     SQETHQAVKL VVNHVECNGG IYGEKYVIPE EDSYMTNPNL TVIVPIAPGE SDVEFLEEEE
     NSDTSDDEDN KEVRGSSPSI LSTVDLRKPG EELDNFSELA EESMEPEECF PEFCVRHCHC
     CHIDVTRGLG QAWWRLRKTC YQIVEHSWFE TFIIFMILLS SGALAFEDIY IEKRKVIKLV
     LEAADKVFSY IFVLEMFLKW IAYGFKKYFT NYWCWLDFLI VDVSLISLAA NSLGYSDFTA
     IKSLRTLRAL RPLRALSRFE GMRVVVNALI GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG
     KFGKCVNRTG FIHSVSVVNN KSDCLAMNDT QFYWTKVKVN FDNVGIGYLS LLQVATFKGW
     MEIMHAAVDS RGVEEQPIRE INIYMYLYFV VFIIFGSFFT LNLFIGVIID NFNQQKRKLG
     GQDIFMTEEQ KKYYNAMKKL GSKKPQKPIP RPTNIIQAFF FDLVSKQAFD IMIMMLIIVN
     MVTMMVETDE QSEHMEAILN KINHVFIVIF TTECLIKIFA LRCYFFTIAW NIFDFVVIIL
     SIVGIVLADL IEKYFVSPTL FRVIRLARIG RVLRLIRAAK GIRTLLFALM MSMPALFNIG
     LLLFLVMFIY AIFGMANFAY VKKQDGIDDM FNFETFGNSM ICLFQISTSA GWDNLLSPIM
     ANSPTECDVN FVNTGTNTRG NCGSPSMGIA FFVSYIIISF LIVVNMYIAI ILENFSVATE
     ESTEPLSEDD FEMFYEVWEK FDSEATQFIE FSMLSNFADT LSEPLRIAKP NMIKLISMDL
     PMVSGDRIHC LDILFAFTKR VLGESGEMDA LKQQMEEKFM MTNPSKVSHE PITSTLRRKV
     EEVSATIIQR CYRRHLVRRQ MKQ
//
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